Trichosporonosis

Fungal infections caused by TRICHOSPORON that may become systemic especially in an IMMUNOCOMPROMISED HOST. Clinical manifestations range from superficial cutaneous infections to systemic lesions in multiple organs.

Also Known As:

Disseminated Trichosporonosis; Invasive Trichosporonosis; Japanese Summer-Type Hypersensitivity Pneumonitis; Summer-Type Hypersensitivity Pneumonitis; Disseminated Trichosporonoses; Infection, Trichosporon; Invasive Trichosporonoses; Japanese Summer Type Hypersensitivity Pneumonitis; Pneumonitides, Summer-Type Hypersensitivity; Pneumonitis, Summer-Type Hypersensitivity; Summer Type Hypersensitivity Pneumonitis; Summer-Type Hypersensitivity Pneumonitides; Trichosporon Infections; Trichosporonoses; Trichosporonosis, Disseminated; Trichosporonosis, Invasive; Trichosporon Infection

Networked: 141 relevant articles (16 outcomes, 14 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infections
2.	Fungemia
3.	Hematologic Neoplasms (Hematological Malignancy)
4.	Aspergillosis
5.	Opportunistic Infections (Opportunistic Infection)

Experts

1.	Tokimatsu, Issei: 7 articles (03/2021 - 01/2003)
2.	Sugita, Takashi: 4 articles (07/2016 - 01/2007)
3.	Nemoto, Tetsuo: 3 articles (06/2020 - 01/2013)
4.	Shibuya, Kazutoshi: 3 articles (06/2020 - 01/2013)
5.	Shinozaki, Minoru: 3 articles (06/2020 - 01/2013)
6.	Tochigi, Naobumi: 3 articles (06/2020 - 01/2013)
7.	Wakayama, Megumi: 3 articles (06/2020 - 01/2013)
8.	González, Gloria M: 3 articles (01/2018 - 04/2014)
9.	Ishii, Hiroshi: 3 articles (01/2015 - 01/2007)
10.	Kadota, Jun-ichi: 3 articles (01/2015 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Trichosporonosis:

1.	Voriconazole (Vfend)FDA LinkGeneric 06/01/2006 - "Efficacy of voriconazole in a guinea pig model of invasive trichosporonosis." 05/01/2018 - "Invasive trichosporonosis treated with voriconazole." 10/01/2016 - "She developed disseminated trichosporonosis in the pre-engraftment period and was successfully treated with voriconazole. " 10/01/2015 - "Primary Cutaneous Trichosporonosis Responsive to Voriconazole." 12/01/2008 - "Early detection of breakthrough trichosporonosis by serum PCR in a cord blood transplant recipient being prophylactically treated with voriconazole."
2.	Antifungal AgentsIBA 04/01/2000 - "Response to antifungal agents is poor, mortality is high and immunological recovery is the most important factor for a favorable outcome in patients with trichosporonosis. " 11/01/1997 - "Experimental disseminated trichosporonosis in mice: tissue distribution and therapy with antifungal agents." 01/01/2000 - "To treat this infection, we studied the efficacy of rhG-CSF alone and in combination with antifungal agents against disseminated trichosporonosis in neutropenic mice. " 01/01/2015 - "Since trichosporonosis is a relatively rare infectious disease, there has been no established breakpoint for this fungus to various antifungal agents, wherein we cannot precisely confirm its sensitivity or resistance to the agents. " 01/01/2007 - "The prophylactic effectiveness of various antifungal agents against the progression of trichosporonosis fungemia to disseminated disease in a neutropenic mouse model."
3.	AzolesIBA 11/01/1992 - "We studied the in vivo antifungal activity of azoles in humans and in a murine model of disseminated trichosporonosis. " 11/01/1992 - "Azole therapy for trichosporonosis: clinical evaluation of eight patients, experimental therapy for murine infection, and review." 01/01/1998 - "Efficacy of amphotericin B and azoles alone and in combination against disseminated trichosporonosis in neutropenic mice." 12/01/1996 - "These in vitro findings confirm the resistance of T.beigelii to amphotericin B and suggest that azoles may be an alternative to the former for the treatment of disseminated trichosporonosis. " 01/01/2019 - "Several clinical cases of Trichosporon infections have been successfully treated with azole therapy, including voriconazole which appeared frequently effective against Trichosporon both in vitro and in vivo. "
4.	Amphotericin B (Amphotericin)FDA LinkGeneric 01/01/1998 - "Furthermore, their combination with amphotericin B may improve the poor outcome seen in profoundly neutropenic patients with disseminated trichosporonosis." 07/01/1991 - "Fatal trichosporonosis is not related to tolerance to amphotericin B." 07/01/1990 - "beigelii may be resistant in vitro to amphotericin B and that this in vitro resistance was correlated with refractory, disseminated trichosporonosis in granulocytopenic patients. " 01/01/2016 - "asahii exhibits the highest MICs to amphotericin B and (ii) voriconazole has the best in vitro efficacy against clinical isolates of Trichosporon spp. Conclusions:Trichosporon infection is not only restricted to hematological patients. " 01/01/1998 - "Efficacy of amphotericin B and azoles alone and in combination against disseminated trichosporonosis in neutropenic mice."
5.	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/01/1996 - "Efficacy of recombinant human granulocyte-colony stimulating factor alone and in combination with antifungal agents against disseminated trichosporonosis in neutropenic mice." 01/01/2003 - "To treat this infection, we studied the efficacy of granulocyte colony-stimulating factor (GCS-F) alone and in combination with antifungal agents against disseminated trichosporonosis in neutropenic mice. "
6.	AntigensIBA 05/01/1993 - "The present study was undertaken to determine the most specific of the 3 serotypes of Trichosporon cutaneum responsible for summer type hypersensitivity pneumonitis and to elucidate the subclass distribution of the antibody response, which is partly dependent on the nature of the causative antigen. " 07/01/1982 - "Japanese summer-type hypersensitivity pneumonitis: studies using Cryptococcus antigen." 07/07/2016 - "Draft Genome Sequence of the Causative Antigen of Summer-Type Hypersensitivity Pneumonitis, Trichosporon domesticum JCM 9580." 11/01/2008 - "Summer-type hypersensitivity pneumonitis was assumed to be caused for about two months duration of expousure to antigen." 12/01/2005 - "The couple were given diagnoses of summer-type hypersensitivity pneumonitis because they were positive for serum anti-Trichosporon mucoides antigen and asahii antigen. "
7.	Fluconazole (Zonal)FDA LinkGeneric 01/01/2007 - "These results suggest that clinical studies are warranted to investigate fluconazole prophylaxis of trichosporonosis progression in neutropenic patients, such as people receiving chemotherapy and patients who have received solid organ transplants." 01/01/2003 - "The results suggested that GCS-F might be a useful immunomodulator against Trichosporon infections in neutropenic mice and the therapeutic outcome improved when used in combination with fluconazole. " 11/01/1994 - "Fluconazole is more active than amphotericin B deoxycholate against experimental murine trichosporonosis." 01/01/2007 - "Compared with the other antifungal agents, fluconazole offered superior prophylaxis against the progression of trichosporonosis fungemia to disseminated disease (P<0.05). " 01/01/1996 - "These findings show that rhG-CSF may be a useful immunomodulator against Trichosporon infections in neutropenic mice and the therapeutic outcome improves when used in combination with fluconazole or amphotericin B."
8.	TriazolesIBA 11/01/2022 - "Triazoles form the mainstay of treatment of Trichosporon infection due to the high susceptibility of the organism in vitro. " 12/01/2019 - "Exploring the resistance mechanisms in Trichosporon asahii: Triazoles as the last defense for invasive trichosporonosis." 10/01/2013 - "Triazoles are currently the drugs of choice for the treatment of Trichosporon infections. " 12/01/2019 - "Treatment of patients with invasive trichosporonosis remains a controversial issue, but triazoles are mentioned by most authors as the best first-line antifungal therapy. " 05/01/2006 - "Some clinical reports and animal models suggest that triazoles and combination therapies are most effective drugs against trichosporonosis. "
9.	Micafungin (FK463)FDA Link 02/01/2005 - "Efficacy of micafungin in combination with other drugs in a murine model of disseminated trichosporonosis." 03/15/2006 - "No cases of trichosporonosis had been seen in the 2 years prior to January 2003, when micafungin became available in our hospital. " 03/15/2006 - "We describe 4 patients who developed disseminated trichosporonosis during the use of micafungin. " 03/15/2006 - "The rarity of trichosporonosis in our hospital and its emergence after the introduction of micafungin therapy support the idea that micafungin may exert a significant, selective pressure toward resistant fungi, such as Trichosporon species. " 06/01/2006 - "Breakthrough trichosporonosis in patients with acute myeloid leukemia receiving micafungin."
10.	SteroidsIBA 07/01/1996 - "Summer-type hypersensitivity pneumonitis was diagnosed, and a steroid was administered because of the prolonged abnormal chest roentgenographic findings. " 11/01/1991 - "A diagnosis of summer-type hypersensitivity pneumonitis was made according to the criteria advocated by Ando et al. This seemed to be a rare case of summer-type hypersensitivity pneumonitis prolonged after isolation from his normal living environment, successfully treated by high-dose administration of steroid." 11/01/1991 - "[A case of severe summer-type hypersensitivity pneumonitis treated with high-dose administration of steroid]." 02/01/2009 - "We diagnosed summer type hypersensitivity pneumonitis and this condition improved in response to antigen isolation and steroids. " 09/01/2011 - "He had numerous risk factors for trichosporonosis, including neutrophilic dysfunction due to prolonged steroid therapy, administration of broad-spectrum antibiotics and micafungin, and central venous catheterization. "

Therapies and Procedures

1.	Therapeutics 03/01/1999 - "In addition, not only can it be used for early diagnosis of trichosporonosis, but it may also be beneficial for monitoring its progress or response to therapy." 06/01/2010 - "asahii is more effective than that of a drug alone against this fungus, suggesting that combined antifungal therapy may be a potential strategy for treating disseminated trichosporonosis." 05/01/1993 - "To obtain a better understanding of its pathogenesis, and to aid in the future study of the therapy of this disease, a murine model of trichosporonosis was developed. " 10/01/2018 - "Difficulties on different species identification as well as the lack of standardized sensitivity tests in vitro, contribute to the limited information available on epidemiology, diagnosis, and therapeutics of Trichosporon infections. " 10/01/2016 - "This case highlights the challenges of managing trichosporonosis in allo-HSCT recipients and suggests the need for lifelong therapy in some patients."
2.	Consolidation Chemotherapy 08/15/2006 - "The patient achieved complete hematological remission, and he received successful consolidation chemotherapy without developing Trichosporon infection with the prophylactic use of voriconazole therapy. "
3.	Drug Therapy (Chemotherapy) 08/01/1993 - "Trichosporonosis occurs most commonly in neutropenic patients receiving chemotherapy. " 10/01/2012 - "Hematologic malignancy, cytotoxic chemotherapy, and organ transplantation are the main risk factors for disseminated Trichosporon infections. " 05/01/2000 - "We describe a 64-year-old woman who developed a superficial Trichosporon infection mimicking hand eczema during chemotherapy for her chronic myelocytic leukemia. " 12/01/2012 - "IFIs were diagnosed in 38 (1.3%) patients (18 proven and 20 probable), including 20 patients who underwent HSCT and 18 who received chemotherapy alone; these included patients with aspergillosis (n = 23), candidiasis (n = 6), mucormycosis (n = 6), trichosporonosis (n = 2), and geotrichosis (n = 1). " 01/01/2007 - "These results suggest that clinical studies are warranted to investigate fluconazole prophylaxis of trichosporonosis progression in neutropenic patients, such as people receiving chemotherapy and patients who have received solid organ transplants."
4.	Humidifiers 04/01/2021 - "Features of humidifier lung and comparison with summer-type hypersensitivity pneumonitis." 11/01/2020 - "Clinical and radiological characteristics of ultrasonic humidifier lung and summer-type hypersensitivity pneumonitis." 01/01/2020 - "[SUMMER-TYPE HYPERSENSITIVITY PNEUMONITIS CAUSED BY A HUMIDIFIER INDUCED IN SPRING, IN A 5-YEAR-OLD GIRL LIVING IN FUKUSHIMA-A CASE REPORT]." 02/01/1995 - "Because the onset was in February, this was not considered to be a case of so-called summer type hypersensitivity pneumonitis a provocation test was done with water from the humidifier he had been using at home. " 09/01/2023 - "ATS/JRS/ALAT Hypersensitivity Pneumonitis Guidelines for Diagnosis of humidifier lung and summer-type hypersensitivity pneumonitis."
5.	Catheters 10/01/2021 - "Disseminated Trichosporon infection occurs sporadically in patients with immunodeficiency, and is mainly manifested as blood, urine, catheter, and thorax/peritoneum infections, rarely as lymphatic, liver and spleen infections. " 01/01/2018 - "Because of the association between invasive infections and the use of catheters and related devices, the ability of the microorganism to adhere and form biofilms may play an important role in the pathogenicity during a trichosporonosis. " 03/01/2021 - "Intravenous catheters, antibiotics, and antifungal uptake were significantly associated risk factors with Trichosporon infection. "