Abstract | BACKGROUND: METHODS: Data from 18 patients with humidifier lung (mean age, 67.3 years) diagnosed during October 2012 through April 2018 were retrospectively reviewed. We compared clinical, laboratory, and CT findings and bronchoalveolar lavage fluid (BALF) characteristics of these patients with those of 19 patients with summer-type HP (mean age, 57.4 years). RESULTS:
Cough and dyspnea were the most common symptoms. White blood cell count and serum C-reactive protein titers were higher for humidifier lung than for summer-type HP. Serum levels of Krebs von den Lungen-6 and surfactant protein D were significantly lower for humidifier lung than for summer-type HP. The most common chest CT findings in humidifier lung were ground-glass opacities (88.9%) and mosaic attenuation (50.0%). Centrilobular ground glass nodules were less common in humidifier lung than in summer-type HP (27.8% vs 63.1%; P = 0.043). Peribronchovascular or subpleural nonsegmental consolidation was more frequent in humidifier lung than in summer-type HP (44.4% vs 5.3%; P = 0.013). Lymphocyte fractions in BALF specimens were significantly lower for humidifier lung than for summer-type HP (37.3% vs 69.0%; P < 0.001). Neutrophil fractions were higher for humidifier lung, but the difference was not significant (22.1% vs 8.1%; P = 0.153). The CD4/8 ratio was higher for humidifier lung than for summer-type HP (1.7 vs 0.8; P = 0.003). CONCLUSIONS: The clinical and radiological characteristics of humidifier lung differ from those of summer-type HP.
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Authors | Susumu Sakamoto, Marie Furukawa, Hiroshige Shimizu, Muneyuki Sekiya, Shion Miyoshi, Yasuhiko Nakamura, Naohisa Urabe, Takuma Isshiki, Yusuke Usui, Kazutoshi Isobe, Yujiro Takai, Atsuko Kurosaki, Kazuma Kishi, Sakae Homma |
Journal | Respiratory medicine
(Respir Med)
2020 Nov - Dec
Vol. 174
Pg. 106196
ISSN: 1532-3064 [Electronic] England |
PMID | 33096316
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 Elsevier Ltd. All rights reserved. |
Chemical References |
- Biomarkers
- C-Reactive Protein
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Topics |
- Aged
- Alveolitis, Extrinsic Allergic
(diagnosis, diagnostic imaging)
- Biomarkers
(analysis, blood)
- Blood Cell Count
- Bronchoalveolar Lavage Fluid
(cytology)
- C-Reactive Protein
- Diagnosis, Differential
- Female
- Humans
- Male
- Middle Aged
- Retrospective Studies
- Tomography, X-Ray Computed
- Trichosporonosis
(diagnosis, diagnostic imaging)
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