Japanese summer-type hypersensitivity pneumonitis: studies using Cryptococcus antigen.

Abstract

Sixty-six patients, diagnosed as Japanese summer-type hypersensitivity pneumonitis at Osaka Prefectural Habikino hospital between 1973 and 1980, were studied. The diagnosis was based on the clinical features and summer-seasonal nature of the disease. The presence of an aetiological agent within patients' home environment was suggested by the recurrence of acute symptoms of high fever, cough and dyspnoea 5-8 hr after coming home from hospital, and by spontaneous improvement on leaving home. Immunological studies revealed the presence of anti-Cryptococcus antibody in sixty-four of sixty-five patients' sera, by indirect immunofluorescence against Cryptococcus neoformans. Precipitating antibody against culture supernatant protein-antigen of Cr. neoformans was detected in more than 80% of sera obtained from patients during the active stage of the disease. The positive result on inhalation provocation-challenge, using culture supernatant protein-antigen, suggested that Cr. neoformans or antigenically related Cryptococcus species may cause Japanese summer-type hypersensitivity pneumonitis.

• Authors: T Miyagawa, S Hamagami, T Ochi, T Osugi, M Kikui, H Takahashi
• Journal: Clinical allergy (Clin Allergy) Vol. 12 Issue 4 Pg. 343-54 (Jul 1982) ISSN: 0009-9090 [Print] England
• PMID: 6749330 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antigens, Fungal

Topics

• Adolescent
• Adult
• Alveolitis, Extrinsic Allergic (immunology)
• Antigens, Fungal (analysis)
• Cryptococcus (immunology)
• Female
• Fluorescent Antibody Technique
• Humans
• Japan
• Male
• Seasons