Abstract |
The activities of amphotericin B, miconazole, fluconazole, and itraconazole against Trichosporon beigelii were assessed in a mouse model of disseminated infection. Cyclophosphamide plus prednisolone-immunosuppressed ICR mice, intravenously challenged with a lethal inoculum of (6 x 10(6) CFU/ mouse), were assigned to receive 7 days of therapy with amphotericin B (0.5 or 2 mg/kg/day), miconazole (10 or 40 mg/kg/day), fluconazole (10 or 40 mg/kg/day), or itraconazole (10 and 40 mg/kg/day). The efficacy of a combination of amphotericin B (1 mg/kg/day) with that fluconazole (10 mg/kg/ day) or itraconazole (20 mg/kg/day) with that of each agent alone was also compared. Both amphotericin B and azoles improved survival and reduced the fungal counts in kidneys of infected mice in a dose-dependent pattern. In general, fluconazole was superior to amphotericin B and the other azoles, whereas the latter two drugs were as effective as amphotericin B. The activity of amphotericin B combined with fluconazole appeared to be superior to that of each agent alone, especially in reducing the organ fungal burden. The other combination ( amphotericin B plus itraconazole) had a weaker effect, but no antagonism was observed. In conclusion, azoles may be an alternative to amphotericin B for the treatment of T. beigelii infection. Furthermore, their combination with amphotericin B may improve the poor outcome seen in profoundly neutropenic patients with disseminated trichosporonosis.
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Authors | P Kamberi, H Atsuro, T Takayoshi, N Masaru |
Journal | Chemotherapy
(Chemotherapy)
1998 Jan-Feb
Vol. 44
Issue 1
Pg. 55-62
ISSN: 0009-3157 [Print] Switzerland |
PMID | 9444410
(Publication Type: Journal Article)
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Chemical References |
- Antifungal Agents
- Azoles
- Itraconazole
- Miconazole
- Amphotericin B
- Fluconazole
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Topics |
- Amphotericin B
(pharmacology)
- Animals
- Antifungal Agents
(pharmacology)
- Azoles
(pharmacology)
- Drug Therapy, Combination
- Fluconazole
(pharmacology)
- Itraconazole
(pharmacology)
- Male
- Mice
- Mice, Inbred ICR
- Miconazole
(pharmacology)
- Microbial Sensitivity Tests
- Mycoses
(blood, drug therapy)
- Neutropenia
(microbiology)
- Trichosporon
(drug effects)
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