Recurrent trichosporonosis with central nervous system involvement in an allogeneic hematopoietic stem cell transplant recipient.

Abstract

Trichosporon is an ubiquitous yeast that has emerged as an opportunistic pathogen in the immunocompromised host. We describe a case of invasive trichosporonosis in an allogeneic hematopoietic stem cell transplant (allo-HSCT) recipient while on caspofungin antifungal prophylaxis. She developed disseminated trichosporonosis in the pre-engraftment period and was successfully treated with voriconazole. She later developed 2 further episodes of invasive trichosporonosis involving the central nervous system. This case highlights the challenges of managing trichosporonosis in allo-HSCT recipients and suggests the need for lifelong therapy in some patients.

• Authors: S Y Thien, S J Chung, A L Tan, W Y K Hwang, B H Tan, T T Tan
• Journal: Transplant infectious disease : an official journal of the Transplantation Society (Transpl Infect Dis) Vol. 18 Issue 5 Pg. 768-772 (Oct 2016) ISSN: 1399-3062 [Electronic] Denmark
• PMID: 27425395 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Antifungal Agents
• Echinocandins
• Lipopeptides
• Triazoles
• posaconazole
• Caspofungin
• Voriconazole

Topics

• Anemia, Aplastic (therapy)
• Antibiotic Prophylaxis (methods)
• Antifungal Agents (administration & dosage, therapeutic use)
• Caspofungin
• Central Nervous System (diagnostic imaging, microbiology)
• Echinocandins (administration & dosage, therapeutic use)
• Female
• Hematopoietic Stem Cell Transplantation (adverse effects)
• Humans
• Hydrocephalus (etiology, surgery)
• Immunocompromised Host
• Immunosuppression Therapy (adverse effects)
• Laminectomy
• Lipopeptides (administration & dosage, therapeutic use)
• Magnetic Resonance Imaging
• Opportunistic Infections (cerebrospinal fluid, complications, drug therapy, microbiology)
• Recurrence
• Transplantation, Autologous
• Treatment Outcome
• Triazoles (administration & dosage, therapeutic use)
• Trichosporon (isolation & purification)
• Trichosporonosis (cerebrospinal fluid, complications, drug therapy, microbiology)
• Ventriculoperitoneal Shunt
• Voriconazole (administration & dosage, therapeutic use)