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Hypersensitivity (Allergy)

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Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Also Known As:

Allergy; Allergies; Allergic Reaction; Allergic Reactions; Hypersensitivities; Reaction, Allergic; Reactions, Allergic

Networked: 42673 relevant articles (1214 outcomes, 3653 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Immune System Diseases: 1611
- Hypersensitivity: 42673

Related Diseases

1.	Asthma (Bronchial Asthma)
2.	Hypersensitivity (Allergy)
3.	Infection
4.	Rhinitis
5.	Inflammation

Experts

1.	Valenta, Rudolf: 45 articles (06/2012 - 01/2002)
2.	Menné, Torkil: 37 articles (10/2012 - 03/2002)
3.	Eisenach, James C: 32 articles (01/2013 - 01/2002)
4.	Bruze, Magnus: 32 articles (11/2012 - 01/2002)
5.	Demoly, P: 30 articles (03/2012 - 01/2000)
6.	Vieths, Stefan: 28 articles (01/2013 - 01/2002)
7.	Valenta, R: 28 articles (09/2012 - 01/2000)
8.	Blanca, M: 27 articles (12/2012 - 07/2001)
9.	Asero, R: 26 articles (09/2012 - 03/2001)
10.	Passalacqua, Giovanni: 24 articles (12/2012 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hypersensitivity:

1.	Immunoglobulin E (IgE)IBA 11/01/2000 - "4) Skin test and/or IgE RAST showed positive results in most cases, suggesting that the response itself is linked to type I allergic reaction. " 11/01/2010 - "In conclusion, it can be stated that 'new' allergies can suddenly arise, there are allergen-specific risk groups, local IgE-production is also possible in the CNS, allergen avoidance can be very effective in terms of primary prevention, sensitization spreading can be made reversible by effective prevention, and finally, certain allergies can luckily become history within a relatively short period of time. " 11/01/1990 - "Sera from 33 patients with mold allergy proven by bronchial provocation were analyzed for specific IgE against six mold species comparing an improved Phadebas RAST with four other techniques. " 01/01/2011 - "These results show that this rapid test for the measurement of total tear IgE is easy to perform on an outpatient basis and may be helpful in the management of ocular allergy." 10/01/2003 - "There is good concurrence between skin testing techniques and various serum measures of specific IgE, and both methods can be used effectively for screening inhalant allergy, although per-test costs for in vitro methods remain higher than comparable costs for skin testing [28]. " Order ALL the reference details at left...
2.	AntigensIBA 08/01/1991 - "Moreover, CV generated delayed-type hypersensitivity to salmonella antigens and also conferred complete protection against 500 LD50 challenge of S. " 08/01/1994 - "However, the delayed-type hypersensitivity responses to parasite antigens were significantly greater in resistant lambs than those in random-bred lambs. " 12/01/1986 - "Dermal hypersensitivity, measured by changes in double skin thickness, was significantly greater in nonpregnant heifers to porin (P less than 0.01) and group 3 (P less than 0.05) antigens at 24 h post-injection, but no significant differences in skin thicknesses or in the nature of the lesions were observed at 48 h. " 09/01/2001 - "Additionally, delayed-type hypersensitivity response to recall antigens improved preoperatively and remained better until hospital discharge. " 03/01/1999 - "The results indicate that TCA treatment was effective in suppressing MCT infiltration, regarded as a major cause of antigen-dependent allergy." Order ALL the reference details at left...
3.	AllergensIBA 02/01/2003 - "To evaluate the safety and efficacy of oral desensitization in patients with allergy induced by the most common food allergens. " 01/01/2011 - "In conclusion, the specific, accurate and reproducible quantification of three important carrot allergens may help to identify less allergenic carrot varieties, as well as to standardize the amount of allergens in extracts used for carrot allergy diagnosis." 01/01/2000 - "In our opinion, the results of SPT should be very carefully examined, when diagnosing occupational allergy, as in some apprentice bakers positive results of SPT to flour allergens are found before vocational training. " 01/01/2005 - "The study results confirm that skin prick tests to common allergens, particularly to moulds, should be performed in bakers before starting occupational exposure and subjects with positive results should be considered as a group of high risk of occupational allergy." 01/12/2011 - "The rapid adsorption of soluble peanut allergens and the continuous binding of allergens released from peanut particulate material suggest the potential efficacy of using AC for gastric decontamination and possible elimination of a biphasic allergic reaction." Order ALL the reference details at left...
4.	VenomsIBA 01/01/2010 - "SCIT is the only and a very effective treatment for insect venom allergy. " 04/01/2006 - "The availability of recombinant Api m 3 provides a tool for both the development of improved diagnostic tests and the design of safer and more effective immunotherapeutic approaches for honeybee venom allergy. " 03/01/2000 - "The findings of this meta-analysis support the conclusion that SIT is effective in the treatment of Hymenoptera venom hypersensitivity." 03/01/1989 - "The epidemiology and natural history of insect venom allergy is emerging in the past decade and has clarified the reasons for the false perceptions that whole body extracts of the insects were considered effective for therapy. " 06/01/2011 - "VIT with 50 μg maintenance dose lasting 5 yr appears to be safe and effective enough to induce tolerance in children with hymenoptera venom hypersensitivity." Order ALL the reference details at left...
5.	AntibodiesIBA 01/01/1989 - "The autolyzates induce the production of specific antibodies, the delayed type of hypersensitivity, and some degree of protection against European virulent strain 130. " 07/01/2011 - "This is contrary to what was proposed in a number of other studies using neutralizing and activating antibodies and questions the clinical relevance of Tim1 and Tim3 for novel allergy therapies." 05/01/2011 - "In summary, the Phl p 5-specific antibodies are the first full set of allergy-related antibody isotypes of their kind and represent valuable tools for studies of fundamental mechanisms and structure/function relationships in allergy." 01/01/2010 - "In this study we aimed to investigate the possible involvement of drug- and/or metabolite-specific antibodies in selective DF hypersensitivity. " 12/01/2008 - "Such tests include mixed leukocyte reactions, enzyme-linked immunosorbent spot assays, trans-vivo delayed-type hypersensitivity assays, and measurement of dendritic cell subsets and anti-donor antibodies; we propose extending these studies to tissue engineering." Order ALL the reference details at left...
6.	Immunoglobulin G (IgG)IBA 02/01/2007 - "IgG4 have been reported as blocking antibody and the protective effects of blocking antibody may be clear in inhalant allergy. " 05/01/2004 - "We show that RA-specific IgG isotype ASC numbers are very useful and sensitive parameters to identify drug-induced hypersensitivity in both PLN and ALN. " 03/01/2002 - "The aim of this study was to investigate the effects of maternal immunization with Dermatophagoides pteronyssinus (Dp) on the hypersensitivity response and IgG subclass production in offspring using a murine model. " 04/01/2000 - "Further studies with oral IgG challenges should be performed to document the conclusion that in vitro reactivity correlates with clinical hypersensitivity. " 01/01/2013 - "The cutaneous hypersensitivity response (CHR) to HEWL challenge was measured on ld30 (n = 20 FM, n = 20 SBM), and blood samples were collected over time to measure the primary and secondary immunoglobulin G (IgG) response to HEWL. " Order ALL the reference details at left...
7.	Penicillins (Penicillin)FDA Link 09/01/1981 - "These results support the position that testing with PPL, PA, and Pen G is a rapid, safe, and effective method for identifying patients at risk, or not at risk, for allergic reactions to penicillin." 11/01/2010 - "Certain points must be improved though: time of the sampling, antibiotic therapy in case of quick delivery, management of patients with allergy to penicillin. " 01/01/2000 - "These agents are effective against gram-negative rods and anaerobes, reach therapeutic levels rapidly after parenteral administration, and, in the absence of penicillin allergy, generally exhibit low toxicity. " 02/01/1980 - "A greater number of patients with clinical hypersensitivity to penicillin had positive results by both the lymphocyte transformation test and the radioallergosorbent test than by either test alone. " 09/01/1998 - "The identification of new specificities has improved the understanding of allergy to penicillins, and different well defined subgroups now exist. " Order ALL the reference details at left...
8.	VaccinesIBA 09/01/2008 - "This information is being applied to the design and production of allergy vaccines, some of which already have proven efficacy and safety in clinical trials." 06/01/2012 - "Successful clinical trials performed with the new vaccines indicate that broad allergy vaccination is on the horizon and may help to control the allergy pandemic." 09/15/2003 - "Specific allergy vaccination is an efficient treatment for allergic disease; however, the development of safer vaccines would enable a more general use of the treatment. " 06/01/2012 - "Vaccines aim to establish or strengthen immune responses but are also effective for the treatment of allergy. " 01/01/2006 - "Sublingual vaccines based on biological extracts from various natural allergen sources are effective in the treatment of respiratory allergies. " Order ALL the reference details at left...
9.	Dentifrices (Dentifrice)IBA 01/01/2008 - "Dentinal hypersensitivity: a 12-week study of a novel dentifrice delivery system comparing different brushing times and assessing the efficacy for hard-to-reach molar teeth." 08/01/2003 - "Anticaries efficacy of a new dentifrice for hypersensitivity." 04/01/2010 - "Efficacy of two commercially available dentifrices in reducing dentinal hypersensitivity." 02/01/1996 - "Assessing the efficacy of three dentifrices in the treatment of dentinal hypersensitivity." 03/01/1992 - "Clinical efficacy of a low abrasive dentifrice for the relief of cervical dentinal hypersensitivity." Order ALL the reference details at left...
10.	Histamine (Histamine Dihydrochloride)FDA Link 01/01/1994 - "In objective examination, nasal provocation testing, nasal hypersensitivity to histamine, the number of mast cells and eosinophils in nasal scraping, and blood basophils showed significant improvement at 6 to 12 months the same as clinical symptoms. " 10/01/1959 - "[The significance of histamine fixation and antihistamine protective effects in the field of allergy theory]." 07/01/2009 - "Being a first-line treatment for hypersensitivity allergic disease, histamine H1-receptor antagonists possess anti-inflammatory activity in addition to being H1-receptor antagonists. " 01/01/2009 - "Skin prick test (SPT) on non-atopic subjects (without any history of eggplant allergy) using four varieties of raw and cooked eggplant extracts revealed that only subjects with a lower threshold for histamine produce positive results equivalent to that seen between 10-100 microg/mL histamine dihydrochloride. " 07/01/2010 - "Histamine is an important mediator of allergic reactions, and recent studies indicated that the function of different types of antigen presenting cells (APC) can be modulated by histamine, in particular via the newly described histamine H(4) receptor (H(4)R). " Order ALL the reference details at left...

Therapies and Procedures

1.	Immunotherapy 07/01/2011 - "The clinical efficacy of the most common routes, subcutaneous (SCIT) and sublingual (SLIT) immunotherapy, is documented for respiratory allergy by double-blind, placebo-controlled, randomised clinical trials (DB PC RCT). " 08/01/2011 - "The assessment of clinical efficacy of immunotherapy in patients with respiratory allergy is highly affected by variability and lack of validated outcome measures such as symptom and medication scores. " 09/01/2012 - "Subcutaneous specific immunotherapy (SCIT) has proven sustained clinical efficacy against allergy. " 01/01/2012 - "The performance of Staloral 300 may provide optimal conditions for an effective and safe sublingual immunotherapy in patients with mite-induced respiratory allergy." 01/01/2012 - "Allergen-specific immunotherapy (SIT) is currently the only curative treatment for allergy but the treatment needs to be improved. " Order ALL the reference details at left...
2.	Injections 01/01/1990 - "When IFN-gamma injections were given during the contact allergic reaction there was no significant reduction of ear swelling until 72 h (p less than 0.01). " 11/01/2001 - "A major potential benefit provided by MPL adjuvant is the promotion of a Th1 response which enhances the efficacy of allergy vaccination and can consequently allow a reduction in the number of injections required for treatment. " 06/01/2004 - "There are a variety of prevention strategies that could be implemented to reduce or eliminate this risk, such as improved nurse training in the administration of allergy injections and compliance with the recommendations in the "Allergen Immunotherapy: A Practice Parameter" for use of patient-specific vials, standardized dosage sheets, and implementation of triple-checking of identity to make sure the correct patient is receiving the correct injection." 11/01/1996 - "The readings, taken 20 minutes after the intradermic injections, with positive results were considered as hypersensitivity of the immediate type. " 03/01/2011 - "In the study of adjuvant effect in TCM injections + OVA (at the dose level that doesn't cause allergic reactions), the PCA results of SHL and YXC were positive and there was a increase in content of serum OVA-sIgE, while the PCA result of QKL was negative with a unobvious increase in the content of serum OVA-sIgE. " Order ALL the reference details at left...
3.	Premedication 04/01/2007 - "The present study was undertaken to standardize skin testing and to develop a safe and effective premedication protocol for administration of ERIG in those with skin test positivity/hypersensitivity. " 11/01/2011 - "However, the effectiveness of premedication has not been properly demonstrated, especially in cases related to non-ionic CM. In this study, we evaluated the effectiveness of premedication at preventing of non-ionic CM immediate-type hypersensitivity reactions. " 08/01/2008 - "This study investigated the allergic reaction ratio to consider the safety and usefulness of the short-time premedication method used at our hospital. " 12/01/1994 - "In nonrandomized trials, doses studied have ranged from 135 mg/m2 to 250 mg/m2 administered over 24 hours with premedication to avoid hypersensitivity reactions (HSRs). " 02/01/1994 - "Fifty-five percent of patients demonstrated hypersensitivity reactions despite the premedication regimen employed, higher than that of the phase I studies which established the dose and schedule used in this trial. " Order ALL the reference details at left...
4.	Oral Administration 08/15/1992 - "Oral administration of the allopeptide mixture to LEW responder rats daily for 5 days before immunization effected significant reduction of delayed-type hypersensitivity responses both to the allopeptide mixture and to allogeneic splenocytes. " 08/15/2008 - "In conclusion, we have shown for the first time that chronic oral administration of selective H(3) antagonists is effective in reversing neuropathic hypersensitivity in disease-related models, and that specific H(3) receptor binding sites are present in the human DRG and dorsal horn of the spinal cord. " 02/01/2001 - "In this study, we investigated the effect of cell cultured SG by oral administration in mast cell-mediated allergic reactions. " 01/01/1998 - "The aim of the present study was to evaluate whether oral administration of rDer f2 could suppress an immediate allergic reaction in mice sensitized with mite allergen. " 06/15/2012 - "In vivo, oral administration of STA significantly inhibited T cell-mediated delayed-type hypersensitivity (DTH) response. " Order ALL the reference details at left...
5.	Drug Therapy (Chemotherapy) 12/01/2005 - "Cytotoxic chemotherapy successfully induces durable complete remission in 2 patients with mosquito allergy resulting from Epstein-Barr virus-associated T-/natural killer cell lymphoproliferative disease." 12/01/2005 - "As of this writing, we have successfully treated 2 patients with mosquito allergy with chemotherapy in which EBV-infected T-/NK cells were eradicated. " 11/01/2005 - "Rapid inpatient/outpatient desensitization for chemotherapy hypersensitivity: standard protocol effective in 57 patients for 255 courses." 01/01/2012 - "In this study we investigated chemotherapy-related hypersensitivity reaction in patients with gynecologic malignancy. " 09/01/2001 - "The aims of this study were to characterize hypersensitivity reactions to chemotherapy in patients with gynecologic malignancies and to determine the utility of oral and intravenous desensitization. " Order ALL the reference details at left...

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