Early detection of breakthrough trichosporonosis by serum PCR in a cord blood transplant recipient being prophylactically treated with voriconazole.

Abstract

An 18-year-old man with myelodysplastic syndrome after stem-cell transplantation developed breakthrough trichosporonosis while being administered voriconazole, a broad-spectrum triazole. Importantly, Trichosporon was detected soon after infection by a screening serum polymerase chain reaction test, but not by blood culture. This case illustrates that the serum polymerase chain reaction assay might be effective for early detection of fungemia in immunocompromised patients, including recipients of stem-cell transplants undergoing prophylactic antifungal therapy using voriconazole, which cannot be assumed to always provide complete protection against Trichosporon infection.

• Authors: Koa Hosoki, Shotaro Iwamoto, Tadashi Kumamoto, Eiichi Azuma, Yoshihiro Komada
• Journal: Journal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 30 Issue 12 Pg. 917-9 (Dec 2008) ISSN: 1536-3678 [Electronic] United States
• PMID: 19131780 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antifungal Agents
• DNA, Fungal
• Pyrimidines
• Triazoles
• Voriconazole

Topics

• Adolescent
• Antifungal Agents (therapeutic use)
• Combined Modality Therapy
• Cord Blood Stem Cell Transplantation
• DNA, Fungal (blood)
• Fungemia (blood)
• Humans
• Male
• Mycoses (blood)
• Myelodysplastic Syndromes (complications, microbiology, therapy)
• Polymerase Chain Reaction
• Prognosis
• Pyrimidines (therapeutic use)
• Triazoles (therapeutic use)
• Trichosporon (genetics, isolation & purification)
• Voriconazole