Topiramate (Topamax)

A sulfamate-substituted fructose analog that was originally identified as a hypoglycemic agent. It is used for the treatment of EPILEPSY and MIGRAINE DISORDERS, and may also promote weight loss.

Also Known As:

Networked: 3136 relevant articles (616 outcomes, 805 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Johnson, Bankole A: 23 articles (02/2016 - 05/2003)
2.	Marson, Anthony G: 21 articles (01/2022 - 03/2007)
3.	Silberstein, Stephen D: 20 articles (11/2019 - 01/2002)
4.	McElroy, Susan L: 17 articles (01/2020 - 01/2003)
5.	Kranzler, Henry R: 16 articles (11/2022 - 10/2007)
6.	Diener, Hans-Christoph: 14 articles (01/2018 - 08/2004)
7.	Ait-Daoud, Nassima: 13 articles (01/2019 - 05/2003)
8.	Hulihan, Joseph: 13 articles (01/2011 - 06/2003)
9.	Swift, Robert M: 11 articles (05/2018 - 05/2003)
10.	Ford, Lisa: 11 articles (01/2017 - 03/2009)

Related Diseases

1.	Migraine Disorders (Migraine) 09/01/2014 - "Topiramate is highly effective in migraine prophylaxis but clinicians using the drug need to be aware of the potential for bothersome or serious adverse events. " 02/01/2010 - "Topiramate is a highly effective drug in migraine prophylaxis and is considered a first-line treatment. " 09/15/2008 - "Topiramate has been shown to be highly effective for preventive treatment of migraine and its use has been significantly increased in the last few years. " 06/24/2013 - "More studies designed specifically to compare the efficacy or safety of topiramate versus other interventions with proven efficacy in the prophylaxis of migraine are needed." 09/01/2009 - "In addition to significantly reducing mean monthly migraine/migrainous and migraine headache days, treatment of chronic migraine with topiramate was effective with regard to several traditionally important and clinically relevant secondary outcomes in migraine prevention trials. "
2.	Seizures (Absence Seizure) 01/01/1999 - "Topiramate had well-documented efficacy as an adjunctive agent for partial-onset seizures in 5 double-blind, parallel trials, reducing seizure frequency by 35-47% at 400 mg/day, the optimal dose for most patients. " 02/01/2022 - "After being prescribed topiramate (TPM), his seizures and EEG abnormalities dramatically improved. " 01/01/2005 - "The results confirmed the earlier data received by the authors that topamax was most effective in generalized convulsive, partial and secondary generalized seizures. " 01/01/2002 - "The preliminary findings of this study suggest that topiramate is very effective against tonic-clonic seizures in alcohol withdrawal syndrome. " 06/01/2011 - "Prospective studies evaluating the safety and efficacy of topiramate for both seizures and neuroprotection will be important in determining whether it deserves widespread use in clinical practice."
3.	Epilepsy (Aura) 12/01/2022 - "Topiramate (TPM) is effective for treating epilepsy, but executive dysfunction is a common side effect that could significantly affect everyday life. " 05/01/2003 - "Significant improvement in frontal lobe associated neuropsychological functions after withdrawal of topiramate in epilepsy patients." 07/01/2023 - "Further studies are necessary to better understand the potential adverse effects and overall efficacy of topiramate XR for the treatment of feline epilepsy." 07/01/2007 - "In terms of remission, Topamax was more effective in adolescents, youths and adults than in younger children, and this pattern was also seen in the treatment of symptomatic epilepsy. " 10/01/2006 - "With its established efficacy for epilepsy treatment and its increased use for other disorders, topiramate-positive findings are more common in death-investigation and human-performance casework. "
4.	Weight Loss (Weight Reduction) 01/01/2014 - "Compared to placebo, there was a significantly greater weight loss with topiramate in all analyses: 9.5 kg (SE 1.17) in the complete case analysis (N = 86), 6.8 kg (SE 0.66) using LOCF (N = 561), 6.4 kg (SE 0.90) using MI (N = 561) and 1.5 kg (SE 0.28) using BOCF (N = 561). " 02/01/2007 - "Topiramate treatment produced significantly greater weight loss than placebo and the majority of this loss was explained by a decrease in body fat stores. " 11/01/2004 - "Significantly greater weight loss was observed in the topiramate-treated group than in those treated with placebo (difference in weight loss between the 2 groups: 2.3 kg [5.1 lb] [3.2%]; 95% CI = 1.3% to 4.4%, p < .01). " 11/01/2016 - "In meta-regression analyses, topiramate's efficacy for total symptoms was moderated by shorter illness duration (P = 0.047), while weight loss was greater in prevention/co-initiation vs. intervention/augmentation RCTs (-4.11 kg, 95% CI: -6.70, -1.52 vs. -1.41 kg, 95% CI: -2.23, -0.59, P < 0.001). " 01/01/2016 - "Topiramate's efficacy for total psychopathology and weight reduction effects were not mediated/moderated by trial duration, topiramate dose, sex, age, inpatient status, baseline Positive and Negative Syndrome Scale, or baseline BMI. "
5.	Alcoholism (Alcohol Abuse) 12/01/2007 - "Four of them achieved bodyweight loss in the 1-month follow up, with an average change of 2.65 kg. Based on the present findings topiramate <100 mg/day may be effective in treating patient with alcohol use disorder, and that topiramate has not shown remarkable benefit of bodyweight loss." 01/01/2004 - "Topiramate is safe and well tolerated, and may be beneficial in the treatment of alcohol dependence. " 05/01/2018 - "The results replicate past findings and suggest that topiramate may be an effective treatment for alcohol use disorder. " 03/01/2016 - "Topiramate is effective for alcohol use disorders (AUDs) among non-psychiatric patients. " 09/01/2003 - "Oral topiramate effective for alcoholism."

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5.	Carbamazepine (Tegretol)
6.	Levetiracetam (Keppra)
7.	Zonisamide (Zonegran)
8.	Oxcarbazepine (Trileptal)
9.	Phentermine (Adipex-P)
10.	Antipsychotic Agents (Antipsychotics)

Related Therapies and Procedures

1.	Therapeutics
2.	Ketogenic Diet
3.	Drug Therapy (Chemotherapy)
4.	Vagus Nerve Stimulation
5.	Psychology Biofeedback (Biofeedback)