Levetiracetam (Keppra)

A pyrrolidinone and acetamide derivative that is used primarily for the treatment of SEIZURES and some movement disorders, and as a nootropic agent.

Also Known As:

Keppra; Etiracetam; Etiracetam, (R)-; Etiracetam, R-isomer; Etiracetam, S-isomer; UCB 6474; UCB-6474; Ucb L059; Ucb L060; Ucb-L059; Ucb-L060; alpha-ethyl-2-oxo-1-Pyrrolidineacetamide; Etiracetam, R isomer; Etiracetam, S isomer; R-isomer Etiracetam; S-isomer Etiracetam; UCB6474; UcbL060; alpha ethyl 2 oxo 1 Pyrrolidineacetamide; 1-Pyrrolidineacetamide, alpha-ethyl-2-oxo-, (alphaS)-

Networked: 2701 relevant articles (445 outcomes, 631 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Marson, Anthony G: 18 articles (01/2022 - 01/2009)
2.	Klitgaard, Henrik: 17 articles (01/2021 - 10/2001)
3.	Verrotti, Alberto: 15 articles (03/2022 - 06/2007)
4.	Stockis, Armel: 14 articles (08/2015 - 12/2003)
5.	Striano, Pasquale: 12 articles (01/2022 - 12/2005)
6.	Löscher, Wolfgang: 12 articles (01/2021 - 04/2002)
7.	Patsalos, Philip N: 12 articles (01/2019 - 02/2002)
8.	Abou-Khalil, Bassel: 12 articles (10/2018 - 05/2003)
9.	Lee, Sang Kun: 11 articles (01/2019 - 07/2007)
10.	Coppola, Giangennaro: 10 articles (05/2021 - 01/2004)

Related Diseases

1.	Seizures (Absence Seizure) 10/25/2023 - "Previous studies have shown that monotherapy with most antiseizure medications can effectively relieve seizures in patients with SeLIE, but the efficacy of levetiracetam has not been investigated. " 08/01/2010 - "Levetiracetam was well tolerated at the doses studied, and appears most effective in single seizure events." 07/01/2008 - "Levetiracetam was effective in both partial and primary generalized seizures, but had most effect in partial seizures. " 06/15/2007 - "Treatment with levetiracetam produced a striking remission of seizures. " 11/01/2014 - "Levetiracetam has been proven to be effective in both partial and generalized seizures in children. "
2.	Epilepsy (Aura) 01/01/2014 - "Understanding the precise mechanisms of action of levetiracetam would be extremely beneficial in helping to understand the processes involved in seizure generation and epilepsy. " 05/01/2008 - "Levetiracetam treatment was safe and effective in this group of very young patients with various types of epilepsy." 01/01/2011 - "The results of the study revealed the high efficacy of levetiracetam as an add-on treatment of pharmacoresistant epilepsy in children. " 10/01/2004 - "Levetiracetam may be effective in generalized-onset epilepsy, and randomized, controlled trials are indicated." 01/01/2021 - "Corroborating the results in the literature, levetiracetam was shown to be effective and safe for children and adults with refractory focal-onset epilepsy."
3.	Status Epilepticus (Complex Partial Status Epilepticus) 08/01/2014 - "Intravenous levetiracetam (LEV) has been shown to be effective and safe in treating adults with refractory status epilepticus (SE). " 03/01/2014 - "Levetiracetam is effective in individuals with electrical status epilepticus during sleep with tolerable side effects." 01/01/2013 - "The relatively recent development of levetiracetam shows promise for effective control of acute status epilepticus in adults, but current objective data of its use as a first-line agent for control of status is quite limited. " 09/01/2009 - "IV levetiracetam was effective in stopping status epilepticus in both infants. " 05/01/2012 - "To study the efficacy of levetiracetam (LEV) in the treatment of electrical status epilepticus during sleep (ESES) in children. "
4.	Partial Epilepsies (Epilepsy, Partial) 01/01/2010 - "The drug withdrawals due to side effects was 5,6% in group 1 and 8,2% in group 2. The results of the study suggest high efficacy of levetiracetam in treatment of partial epilepsy." 06/30/2020 - "Overall, this review update finds that in both adults and children with drug-resistant focal epilepsy, levetiracetam added on to usual care is more effective than placebo at reducing seizure frequency, it is unlikely to be stopped by patients, and it has minimal adverse effects outside of potential worsening behaviour in children. " 12/01/2002 - "Levetiracetam may be more effective for late-onset partial epilepsy." 03/01/2006 - "The aim of the present study is to verify whether patients with partial epilepsy receiving levetiracetam (LEV) as an add-on treatment show an improvement in cognitive function. " 05/01/2011 - "The safety and efficacy of add-on levetiracetam in elderly patients with focal epilepsy: a one-year observational study."
5.	Drug Resistant Epilepsy 03/01/2017 - "Our findings suggest that even for intractable pediatric cases with symptomatic etiology (i.e., MRI lesion and ID), levetiracetam has favorable efficacy for refractory epilepsy with tolerable adverse effects." 08/01/2005 - "Fast and sustained efficacy of levetiracetam during titration and the first 3 months of treatment in refractory epilepsy." 05/01/2010 - "Therefore, the authors conclude that levetiracetam treatment is effective and safe in young children with refractory epilepsy." 01/01/2013 - "The purpose of this study was to determine the efficacy of levetiracetam (LEV) on SBS, seizure frequency, and neuropsychological impairments in children with refractory epilepsy. " 08/01/2010 - "Efficacy of levetiracetam in children with refractory epilepsy as an add-on trial."

Related Drugs and Biologics

1.	Anticonvulsants (Antiepileptic Drugs)
2.	Valproic Acid (Depakote)
3.	Phenytoin (Dilantin)
4.	Lamotrigine (Lamictal)
5.	Topiramate (Topamax)
6.	Carbamazepine (Tegretol)
7.	Phenobarbital (Luminal)
8.	Zonisamide (Zonegran)
9.	Levetiracetam (Keppra)
10.	Gabapentin (Neurontin)

Related Therapies and Procedures

1.	Therapeutics
2.	Vagus Nerve Stimulation
3.	Ketogenic Diet
4.	Relaxation Therapy (Relaxation Technique)
5.	Psychology Biofeedback (Biofeedback)