Gabapentin (Neurontin)

A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.

Also Known As:

Neurontin; 1-(Aminomethyl)cyclohexaneacetic Acid; Apo-Gabapentin; Convalis; Gabapentin Hexal; Gabapentin Stada; Gabapentin-Ratiopharm; Novo-Gabapentin; PMS-Gabapentin; Apo Gabapentin; ApoGabapentin; Gabapentin Ratiopharm; Novo Gabapentin; NovoGabapentin

Networked: 4043 relevant articles (879 outcomes, 993 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Gilron, Ian: 17 articles (11/2019 - 01/2005)
2.	Granados-Soto, Vinicio: 16 articles (01/2019 - 01/2003)
3.	Marson, Anthony G: 13 articles (01/2022 - 03/2007)
4.	Guttuso, Thomas: 13 articles (01/2021 - 02/2003)
5.	Loprinzi, Charles L: 13 articles (11/2014 - 05/2003)
6.	Ono, Hideki: 13 articles (01/2014 - 12/2004)
7.	Tanabe, Mitsuo: 12 articles (05/2021 - 12/2004)
8.	Eisenach, James C: 12 articles (09/2019 - 03/2007)
9.	Moore, R Andrew: 12 articles (01/2017 - 08/2008)
10.	Wiffen, Philip J: 11 articles (01/2017 - 01/2010)

Related Diseases

1.	Pain (Aches) 11/26/2002 - "Patients whose symptoms included pain benefited most from gabapentin. " 01/01/2017 - "More participants (52%) had moderate benefit (at least 30% pain relief or PGIC much or very much improved) with gabapentin at 1200 mg daily or greater than with placebo (37%) (RR 1.4 (95% CI 1.3 to 1.6); NNT 6.6 (4.9 to 9.9); 7 studies, 1439 participants, moderate-quality evidence).For all conditions combined, adverse event withdrawals were more common with gabapentin (11%) than with placebo (8.2%) (RR 1.4 (95% CI 1.1 to 1.7); NNH 30 (20 to 65); 22 studies, 4346 participants, high-quality evidence). " 03/01/2008 - "After surgery, the patient continued to experience pain; however, his pain resolved completely after several weeks of receiving gabapentin 600 mg 3 times/day. " 08/01/2021 - "Pain scores in the overall study population were not significantly reduced when gabapentin was added to standard treatment; however, gabapentin benefited individuals with the more severe genotype, HbSS, during acute VOC. " 01/01/2022 - "A statistically significant improvement on leg pain at 2 weeks and leg pain with movement at 3 and 4 months was found in a RCT comparing gabapentin with placebo. "
2.	Neuralgia (Stump Neuralgia) 06/01/2004 - "Ease of use and broad therapeutic range, in addition to demonstrated efficacy, make gabapentin the drug of choice for most neuropathic pain disorders. " 04/27/2014 - "Second tier evidence, with potentially important residual biases, showed that gabapentin at doses of 1200 mg or more was effective for some people with some painful neuropathic pain conditions. " 09/01/2012 - "The results of this study show that gabapentin is effective in acute herpetic neuralgia in different doses with 600 mg/day being the more appropriate dose in terms of safety and efficacy." 01/01/2002 - "Future studies with larger sample sizes, higher dosages, and quicker titration will help further determine the efficacy of gabapentin in the treatment of SCI-related neuropathic pain." 05/01/2001 - "Gabapentin has an established, favorable safety profile and has been shown to be effective in various animal models and human studies of chronic neuropathic pain. "
3.	Postoperative Pain 01/01/2021 - "Conclusion: Preoperative oral gabapentin as an adjunct to surgery is effective in decreasing the risk and severity of CRBD over a short time after surgery, and it can decrease postoperative pain without significant side effects. " 03/01/2011 - "Gabapentin has been introduced as an effective agent for post-operative pain control. " 01/01/2011 - "Gabapentin is effective for preventing and treating acute and chronic postoperative pain; however, it has not been described for use in cesarean delivery. " 09/01/1997 - "It is suggested that gabapentin and S-(+)-3-isobutylgaba may be effective in the treatment of postoperative pain." 01/01/2023 - "Of the studies assessing postoperative pain, 6/11 studies saw a decrease in postoperative pain in at least one period for the gabapentin group. "
4.	Seizures (Absence Seizure) 01/01/2004 - "The preliminary findings of this study suggest that gabapentin is very effective against tonic-clonic seizures in alcohol withdrawal syndrome. " 08/01/2006 - "Gabapentin 1200 mg/day and 1800 mg/day significantly reduced the frequency of refractory seizures compared to placebo. " 12/01/1995 - "Gabapentin used as an add-on AED significantly reduced the frequency of partial seizures and secondarily generalized tonic-clonic seizures in three large double-blind, placebo-controlled, parallel-group clinical trails. " 06/01/1994 - "Gabapentin, has shown significant promise in the treatment of patients with refractory partial seizures and secondarily generalized tonic-clonic seizures. " 05/01/2003 - "However, recent studies have used higher doses and faster titration schedules than those used in the pivotal trials that established the efficacy of gabapentin in the treatment of partial seizures. "
5.	Postherpetic Neuralgia 01/01/2018 - "A Meta-Analysis of Therapeutic Efficacy and Safety of Gabapentin in the Treatment of Postherpetic Neuralgia from Randomized Controlled Trials." 11/01/2001 - "Thus, this study confirms the role of gabapentin as an efficacious and well-tolerated treatment for postherpetic neuralgia." 04/01/1996 - "Gabapentin as a novel treatment for postherpetic neuralgia." 01/01/2017 - "Efficacy of gabapentin for prevention of postherpetic neuralgia: study protocol for a randomized controlled clinical trial." 09/01/2012 - "The efficacy of once-daily gastroretentive gabapentin for the management of postherpetic neuralgia has been demonstrated in placebo-controlled clinical studies. "

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8.	Amitriptyline (Elavil)
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10.	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)

Related Therapies and Procedures

1.	Therapeutics
2.	Analgesia
3.	Drug Therapy (Chemotherapy)
4.	Premedication
5.	Aftercare (After-Treatment)