Pregabalin (Lyrica)

A gamma-aminobutyric acid (GABA) derivative that functions as a CALCIUM CHANNEL BLOCKER and is used as an ANTICONVULSANT as well as an ANTI-ANXIETY AGENT. It is also used as an ANALGESIC in the treatment of NEUROPATHIC PAIN and FIBROMYALGIA.

Also Known As:

Lyrica; (R-)-3-isobutyl GABA; (S)-3-(aminomethyl)-5-methylhexanoic acid; (S+)-3-isobutyl GABA; 3-(aminomethyl)-5-methylhexanoic acid; 3-isobutyl GABA; CI 1008; CI-1008; 1008, CI; 3 isobutyl GABA; CI1008; GABA, 3-isobutyl

Networked: 2755 relevant articles (678 outcomes, 891 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Parsons, Bruce: 40 articles (01/2021 - 01/2013)
2.	Emir, Birol: 39 articles (08/2019 - 07/2008)
3.	Whalen, Ed: 29 articles (01/2021 - 06/2005)
4.	Pauer, Lynne: 25 articles (11/2021 - 09/2008)
5.	Rejas, Javier: 19 articles (01/2015 - 05/2009)
6.	Cappelleri, Joseph C: 18 articles (01/2021 - 06/2009)
7.	Arnold, Lesley M: 18 articles (01/2018 - 06/2006)
8.	Knapp, Lloyd: 17 articles (01/2020 - 06/2010)
9.	Sadosky, Alesia: 17 articles (01/2018 - 08/2007)
10.	Pérez, Concepción: 15 articles (01/2020 - 05/2009)

Related Diseases

1.	Pain (Aches) 01/01/2020 - "Pregabalin was the most frequently studied medication, showing improvement in pain and sleep symptoms. " 06/01/2017 - "Pregabalin appears to be a well-tolerated, safe and effective drug in reducing most of USRS, especially relief of pain with subsequent improvement of patient's quality of life. " 01/01/2017 - "Pregabalin significantly improved both pain and PRSI scores relative to placebo at most dose levels and time points examined. " 07/01/2014 - "Pregabalin ≥ 300 mg/day was most effective for ≥ 30% and ≥ 50% pain reduction [relative risk (RR) vs. placebo = 2.44 and 2.13, respectively]. " 07/30/2016 - "There were significant improvements with pregabalin versus placebo in secondary outcomes of change in pain score by week (P < 0.05 for 10 of 15 weeks); change in pain score at week 15 (1-week recall), treatment difference (95 % CI), -0.87 (-1.68, -0.05), P = 0.037; and patient global impression of change, 53.1 % versus 29.5 % very much or much improved (P = 0.013). "
2.	Neuralgia (Stump Neuralgia) 11/01/2008 - "These results suggest that pregabalin may be beneficial in patients with neuropathic pain who have had an unsatisfactory response to treatment with other medications." 01/01/2021 - "Combined Treatment of Adipose Derived-Mesenchymal Stem Cells and Pregabalin Is Superior to Monotherapy for the Treatment of Neuropathic Pain in Rats." 08/01/2010 - "Flexible-dose pregabalin 150-600 mg/day was effective in relieving neuropathic pain, improving disturbed sleep, improving overall patient status, and was generally well tolerated in patients with post-traumatic peripheral neuropathic pain." 01/01/2016 - "Earlier studies and case reports have shown pregabalin to be effective in treating neuropathic pain. " 01/01/2022 - "Pregabalin was found to be effective for neuropathic pain vs placebo. "
3.	Postoperative Pain 07/01/2020 - "Preoperative administration of oral pregabalin in a single dose of 150 mg appears to be effective to significantly reduce the anxiety of patients, intraoperative hemodynamic changes, and postoperative pain. " 06/22/2023 - "Pregabalin as an effective treatment for acute postoperative pain following spinal surgery without major side effects: protocol for a prospective, randomized controlled, double-blinded trial." 12/27/2017 - "Is perioperative pregabalin effective for reducing postoperative pain in major surgery?" 12/01/2016 - "The main objective of the present study was to compare the improvement in post-operative pain management and patient lifestyle in 3 groups, as first group received placebo, second who received Pregabalin for one day and the last group those who received it for 14 days. " 03/01/2015 - "Pregabalin is effective in reducing postoperative pain after oculoplastic procedures when compared with placebo. "
4.	Fibromyalgia (Fibrositis) 07/01/2015 - "Pregabalin significantly improved Hospital Anxiety and Depression Scale-Anxiety (difference -0.95, p < 0.0001) and -Depression (difference -0.88, p = 0.0005) scores, Fibromyalgia Impact Questionnaire total score (difference -6.60, p < 0.0001), and sleep quality (difference 0.57, p < 0.0001), but not EuroQol 5-Dimensions score (difference 0.02, p = 0.3854). " 10/01/2014 - "Time to LTR was significantly longer with pregabalin CR versus placebo in fibromyalgia patients who initially showed improvement with pregabalin CR, indicating maintenance of response. " 10/11/2010 - "These results suggest that pregabalin may be beneficial in patients with fibromyalgia who have had an unsatisfactory response to treatment with other medications." 07/01/2010 - "For PGIC, administration of pregabalin resulted in an increase in the proportion of patients reporting improvement with an ED50 of 228 mg. The analyses support the recommended dose of pregabalin in patients with fibromyalgia of 300 to 450 mg/d." 01/01/2008 - "Pregabalin is, therefore, a valuable option in the first-line treatment of patients with fibromyalgia."
5.	Anxiety Disorders (Anxiety Disorder) 03/01/2012 - "Although pregabalin has demonstrated efficacy in the treatment of generalized anxiety disorder (GAD) in a number of randomized controlled trials, there is little published data on the optimal dose for treating this condition. " 02/01/2004 - "High dose pregabalin is effective for the treatment of generalised anxiety disorder." 04/01/2005 - "This study demonstrates that pregabalin is an effective treatment of generalized anxiety disorder, with BID dosing showing similar efficacy and comparable tolerability with TID dosing." 03/01/2003 - "These results indicate that pregabalin is an effective, rapidly acting, and safe treatment for generalized anxiety disorder. " 11/01/2008 - "Pregabalin, in doses of 150-600 mg/day, was a safe and effective treatment of generalised anxiety disorder in patients 65 years and older. "

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