[Topamax in the treatment of epilepsy].

Abstract

To specify efficacy of topamax in different types of epileptic seizures and its influence on patient's quality of life (QL), the drug was assigned to 38 patients, aged 18-69 years, as mono- and polytherapy (in combination with other anticonvulsive medications). Topamax dosages ranged from 25-50 mg at a base-line to 600 mg. Treatment duration was 6-18 months. Positive effect of different extent was achieved in 95.7% patients. A seizures frequency decreased by 25% in 17.4% patients; by 50%--in 8.7%; by 75%--in 43.5%; a complete disappearance of seizures was detected in 30.4%. The results confirmed the earlier data received by the authors that topamax was most effective in generalized convulsive, partial and secondary generalized seizures. It exerts a less pronounced effect in myoclonic seizures and absences. After topamax treatment, a total QL index measured by WHO questionnaire increased by 5.2%. The drug is well tolerated and does not affect cognitive functions of the patients. It is concluded that currently topamax is one of the most effective antiepileptic medications.

• Authors: S A Gromov, L V Lipatova
• Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) Vol. 105 Issue 5 Pg. 28-31 ( 2005) ISSN: 1997-7298 [Print] Russia (Federation)
• PMID: 15952537 (Publication Type: Journal Article)

Chemical References

• Anticonvulsants
• Topiramate
• Fructose

Topics

• Adolescent
• Adult
• Anticonvulsants (administration & dosage, therapeutic use)
• Cognition Disorders (diagnosis, etiology)
• Drug Administration Schedule
• Epilepsy (complications, drug therapy)
• Female
• Fructose (administration & dosage, analogs & derivatives, therapeutic use)
• Humans
• Male
• Middle Aged
• Neuropsychological Tests
• Quality of Life (psychology)
• Topiramate