Bacillus thuringiensis Toxins

Endotoxins produced by BACILLUS THURINGIENSIS used in transgenic plants and insecticides. When eaten by a susceptible insect they are protease activated in the insect midgut resulting in death from bacterial septicemia.

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Networked: 19 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mendoza-Almanza, Gretel: 2 articles (01/2020 - 01/2019)
2.	Wang, Ping: 1 article (10/2020)
3.	Wang, Shaohua: 1 article (10/2020)
4.	Boonserm, Panadda: 1 article (08/2020)
5.	Chankamngoen, Wasutorn: 1 article (08/2020)
6.	Janvilisri, Tavan: 1 article (08/2020)
7.	Promdonkoy, Boonhiang: 1 article (08/2020)
8.	Ayala-Luján, Jorge L: 1 article (01/2020)
9.	Esparza-Ibarra, Edgar L: 1 article (01/2020)
10.	Godina-González, Susana: 1 article (01/2020)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "Bacillus thuringiensis toxins are effective against multiple biological targets such as insects, nematodes, mites, protozoa, and importantly, human cancer cells. " 08/01/2020 - "The latter is one of the Bacillus thuringiensis toxins that exhibits specific cytotoxicity against human cancer cells. " 01/01/2020 - "The Cytocidal Spectrum of Bacillus thuringiensis Toxins: From Insects to Human Cancer Cells."
2.	Spasm (Spasms) 03/01/2008 - "analyzing the efficacy of botulin toxin (BT) use in the rehabilitation of totally laryngectomized patients with tracheo-esophageal voice (TEV) with spasms (S) of the pharyngo-esophageal segment (PES) without myotomy. "
3.	Body Weight (Weight, Body) 10/18/2022 - "The diet mixture bioassay showed that body-weight gain of lacewing larvae was significantly affected by various treatments, especially at lower concentrations of plant-expressed Bt toxin in the diet mixture, which caused significant decreases in body-weight gain. " 03/01/2007 - "The KMD1 rice contained 15mg Bt toxin/kg and based on the average feed consumption the daily intake was 0.54mg Bt toxin/kg body weight. " 01/01/2014 - "A first study on the effects of transgenic cotton on a non-target mealybug, Ferrisia virgata (Cockerell) (Hemiptera: Pseudococcidae) was performed by comparing its development, survival and body weight on transgenic cotton leaves expressing Cry1Ac (Bt toxin) + CpTI (Cowpea Trypsin Inhibitor) with those on its near-isogenic non-transgenic line. "
4.	Sepsis (Septicemia) 01/01/2011 - "The study by Mason et al. [mBio 2(3):e00065-11, 2011] revealed that Bt toxin enables an inhabitant of the midgut, Enterococcus faecalis, to enter the hemolymph of larvae and cause septicemia, leading to death."
5.	Infections 10/01/2009 - "Additional research is required to further delineate the physiological basis for enhanced baculovirus infection following exposure to sublethal doses of Bt toxins." 02/01/2009 - "Up-regulation of repat genes has been observed after challenging the larvae with both Bacillus thuringiensis toxins and after infection with the baculovirus Autographa californica multiple nucleopolyhedrovirus. " 12/01/1994 - "Transgenic r0 and R1 tobacco plants expressing CMV-CP and Bt toxin genes were protected from CMV infection as well as feeding damage of Manduca Sexta (tobacco hornworm) larvae. " 02/10/2014 - "Aminopeptidases N (APNs), the receptors of Bacillus thuringiensis (Bt) toxin in the lepidopteran midgut, are involved in the Bt pathogen infection mechanism. " 10/01/2009 - "We investigated the physiological basis for increased susceptibility to virus infection following exposure to Herculex I by analyzing the midgut pH, gut protease activity and peritrophic matrix structure which are important factors for both Bt toxin action and baculovirus infection. "

Related Drugs and Biologics

1.	Botulinum Toxins (Botulinum Toxin)
2.	Trypsin Inhibitors
3.	Sodium
4.	Proteins (Proteins, Gene)
5.	Peptide Hydrolases (Proteases)
6.	Insecticides
7.	Enzymes
8.	Aminopeptidases

Related Therapies and Procedures

1.	Myotomy
2.	Therapeutics
3.	Injections