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Peptide Hydrolases (Proteases)

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Hydrolases that specifically cleave the peptide bonds found in PROTEINS and PEPTIDES. Examples of sub-subclasses for this group include EXOPEPTIDASES and ENDOPEPTIDASES.

Also Known As:

Proteases; Peptidases; Proteinases; Proteolytic Enzymes; Esteroproteases

Networked: 6645 relevant articles (90 outcomes, 463 trials/studies) for this Bio-Agent, Comments

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 29113
  - Hydrolases: 571
    - Peptide Hydrolases: 6645

Experts

1.	Scorilas, Andreas: 12 articles (12/2012 - 03/2004)
2.	Sloane, Bonnie F: 12 articles (01/2012 - 03/2002)
3.	Bunnett, Nigel W: 11 articles (10/2012 - 11/2002)
4.	Rao, Jasti S: 11 articles (09/2012 - 07/2003)
5.	Vergnolle, Nathalie: 10 articles (09/2009 - 04/2002)
6.	Bogyo, Matthew: 9 articles (10/2012 - 02/2008)
7.	Diamandis, Eleftherios P: 9 articles (09/2012 - 10/2008)
8.	López-Otín, Carlos: 9 articles (01/2012 - 01/2002)
9.	Matrisian, Lynn M: 8 articles (01/2012 - 12/2003)
10.	Kido, Hiroshi: 8 articles (01/2012 - 05/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1990 - "These results demonstrate that the proteolytic enzymes used in these experiments were beneficial in preventing tumor development and prolonging survival of C3H/HEJ mice when used in the appropriate concentration range. " 01/01/1999 - "Although there has been much interest over the years in the medical use of orally administered proteolytic enzymes, there is considerable controversy about their efficacy against advanced stages of cancer. " 06/01/1973 - "These results support the idea that proteolytic enzymes are associated with invasion and that inhibitors of protease activity could possibly be useful in the management of clinical cancer." 08/01/1986 - "A possible role for tumor cell membrane proteases in basement membrane invasion, in which the substrates of the protease bind to receptor sites near a membrane associated proteolytic activity, is not eliminated." 10/01/2012 - "Our studies uncover novel mechanisms of in vivo tumor control by modulation of the balance between tumor proteases and inhibitors, which may be exploited therapeutically." Order ALL the reference details at left...
2.	Inflammation 09/01/2003 - "In contrast, blockade of pancreatic proteases in the intestinal lumen significantly improved hemodynamic parameters and reduced all indices of inflammation in plasma and cell injury in skeletal muscle microcirculation. " 06/01/1997 - "When the system is inadequate or its capacity is exceeded, as in inflammation of the pancreas, exocrine secretions entering the interstitium are not cleared and the proteolytic enzymes cause major damage to the tissue. " 01/27/1999 - "In order to fully evaluate the potential pharmacologic efficacy of human SLPI in animal models of inflammation, it is critical to know the potency of the inhibitor for corresponding proteases from the species of interest. " 01/01/1972 - "[Evaluation of the efficacy of proteolytic enzymes by oral route in the control of postsurgical inflammation of the hand]." 10/01/2012 - "In recent years, a number of studies have investigated the importance of allergen-associated proteases in modulating allergic airway inflammation. " Order ALL the reference details at left...
3.	Infection 07/01/2012 - "This study will potentially open the way towards the development of a tight-binding peptidic inhibitor against fungal aspartic proteases to combat human fungal infections." 05/01/2009 - "In this study, we focus on the prediction of proteases, which have long been considered attractive drug targets because of their indispensable roles in parasite development and infection. " 01/01/2008 - "In conclusion, the studies reviewed herein illustrate how regulation of parasite proteases may affect host-parasite equilibrium in the course of IT cruzi infection." 12/01/2004 - "The present study represents the first to employ anti-fish bacterial OMP sera to screen genes of membrane-associated proteases of fish pathogenic bacteria, and to provide necessary information for the examination of the role of the two genes in the infection and pathogenesis of F. " 06/06/2004 - "Furthermore, several studies indicate that virus proliferation can be arrested using specific proteinase inhibitors supporting the belief that proteinases are indeed important during infection. " Order ALL the reference details at left...
4.	Alzheimer Disease (Alzheimer's Disease) 01/01/2000 - "Controlling the damage to proteases or controlling the generator(s) of oxidative stress may help to control the onset or progression of Alzheimer's disease." 04/01/2008 - "The aims of this study were to determine (i) the distribution of MMP-2, -3 and -9 in the cerebral cortex in Alzheimer's disease (AD) and control brains; (ii) whether the levels and activity of these proteases are increased in AD; and (iii) whether their activity is related to Abeta load. " 01/01/1991 - "Studies on the proteolytic degradation of the beta-protein precursor by proteases purified from Alzheimer's disease brain." 04/01/2010 - "Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process." 01/01/2009 - "The autophagic lysosomal system contributes to the removal of cytosolic components, and abnormality of lysosomal proteases has been reported in the brain of patients with Alzheimer's disease (AD). " Order ALL the reference details at left...
5.	Pancreatitis 01/01/2006 - "Attempts at reducing pancreatic enzyme output or inhibiting the activity of digestive enzyme proteases have not yielded encouraging results - nor have anti-inflammatory strategies for the treatment of acute pancreatitis been found to be effective so far. " 07/01/1985 - "The sorbents were demonstrated to be effective in the removal of proteases from canine blood in acute pancreatitis." 04/01/2003 - "Some studies demonstrate the crucial role of proteases in the pathogenesis of acute pancreatitis (AP). " 12/01/1996 - "The involvement of proteases and microcirculatory derangement early in the course of acute pancreatitis are the main concern of this study. " 04/01/1995 - "A number of modalities to inhibit pancreatic secretion or pancreatic proteases have not been successful in clinical trials, although larger studies in patients with more severe pancreatitis are required to ultimately assess their effectiveness. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Cytokines
2.	Protease Inhibitors (Protease Inhibitor)
3.	Matrix Metalloproteinases
4.	Trypsin
5.	Proteins (Proteins, Gene)
6.	LDL-Receptor Related Protein 1 (LDL-Receptor Related Protein)
7.	Antigens
8.	Chymotrypsin
9.	Reactive Oxygen Species (Oxygen Radicals)
10.	Cathepsin L

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy
3.	Oral Administration
4.	Highly Active Antiretroviral Therapy (HAART)
5.	Parenteral Nutrition

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