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Neoplasms (Cancer)

New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Also Known As:

Cancer; Tumor; Tumors; Cancers; Neoplasm; Benign Neoplasm; Benign Neoplasms; Neoplasms, Benign; Neoplasm, Benign

Networked: 516559 relevant articles (25767 outcomes, 65775 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Neoplasms: 516559

Related Diseases

1.	Neoplasms (Cancer)
2.	Neoplasm Metastasis (Metastasis)
3.	Pain (Aches)
4.	Breast Neoplasms (Breast Cancer)
5.	Carcinoma (Carcinomatosis)

Experts

1.	Zhang, Wei: 200 articles (01/2013 - 04/2002)
2.	Wang, Wei: 162 articles (01/2013 - 01/2002)
3.	Li, Yan: 154 articles (01/2013 - 03/2002)
4.	Li, Wei: 129 articles (01/2013 - 01/2002)
5.	Li, Li: 122 articles (02/2013 - 01/2002)
6.	Zhang, Li: 120 articles (12/2012 - 11/2002)
7.	Aggarwal, Bharat B: 114 articles (01/2013 - 01/2002)
8.	Chen, Xiaoyuan: 111 articles (12/2012 - 01/2004)
9.	Sarkar, Fazlul H: 109 articles (01/2013 - 01/2002)
10.	Hortobagyi, Gabriel N: 105 articles (01/2013 - 01/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neoplasms:

1.	Cisplatin (Platino)FDA LinkGeneric 01/01/2013 - "Cisplatin is one of the most important chemotherapeutic agents useful in the treatment of a variety of solid tumors; however, it has several side effects such as nephrotoxicity. " 08/01/2011 - "Although cisplatin attacks various tumors with remarkable efficacy, its clinical usage has been limited by its side effects, particularly nephrotoxicity. " 01/01/2009 - "These drugs show great promise in vitro against a number of cancer cell lines and due to their polymeric nature will most likely be less toxic than currently used metal-containing drugs such as cisplatin. " 04/01/1999 - "Stressed cells, however, become hypersensitive to cisplatin, one of the most effective drugs against solid tumors, suggesting that preferential cytotoxicity to stressed cells may be important for the clinical efficacy against solid tumors. " 07/01/1996 - "Moreover, hMSH2 is overexpressed in testicular and ovarian tissue; tumors in these tissues are most effectively treated by cisplatin. " Order ALL the reference details at left...
2.	AntigensIBA 02/01/1987 - "In our own studies two types of approaches were also effective with the highly metastatic mouse tumor line ESb which carries a weak tumor associated antigen. " 06/01/2007 - "The Ab/SA conjugate yielding the best tumor uptake and tumor-to-normal organ ratios of radioactivity varied depending on the target antigen expression on the cell line used, with 1F5/SA and Lym-1/SA yielding the most promising results overall. " 01/01/2006 - "For this reason, DC-based immunization has been shown to be highly effective in eliciting CTL responses to viruses and tumor-associated antigens. " 06/15/2004 - "The results show that the targeting of antigen to DCs in this way is highly effective at inducing immunity and protection against the tumor, with protection being at least partially dependent on the eosinophil chemokine eotaxin." 01/01/1978 - "It was found that most patients show an impaired immunobiological response, manifested in higher percentage of positive results with RHDT performed with the tumor antigen, and the reaction of microprecipitation with tumor and embryonal antigens, more week RFC and RBT. " Order ALL the reference details at left...
3.	DNA (Deoxyribonucleic Acid)IBA 09/01/2010 - "Consistent with the biological phenotype, epigenomic studies revealed that TRAMP; Dnmt1 hypomorphic mice show dramatically reduced CpG island and promoter DNA hypermethylation in late-stage primary tumors compared to control mice. " 09/01/2010 - "Improved detection methods have led to increased knowledge on cell-free DNA, and recent studies showed that most cancer patients have increased levels of cell-free DNA. " 01/01/2012 - "The standard paradigm for radiation effects in cellular systems involves damage of the DNA including DNA double-strand breaks, which are considered as most effective in destroying tumor cells. " 06/01/2010 - "The number of cells accumulating in the sub-G0/G1 stage of the cell cycle was increased 2- to 7-fold, and cells in G(2)/M increased 1.5- to 20-fold, indicating that the treatment protocol was highly effective in suppressing DNA synthesis and potentially reflecting DNA damage in the tumor cells. " 03/01/2010 - "They are most effective in the setting of inherent DNA repair defects, such as in cancers resulting from BRCA gene mutations, or in the setting of DNA-damaging chemotherapeutic agents. " Order ALL the reference details at left...
4.	Doxorubicin (Adriamycin)FDA LinkGeneric 03/15/2009 - "Our results showed the remarkable capability of 2C5-targeted Doxil to specifically deliver its cargo into various tumors, significantly increasing the efficacy of therapy." 01/01/2009 - "Our results clearly show the remarkable capability of 2C5-targeted Doxil to specifically deliver its cargo into various tumor manifestations (solid and metastatic) significantly increasing the efficacy of therapy." 03/15/2006 - "Doxorubicin (DOX) is a highly effective treatment for several forms of cancer. " 02/01/2006 - "Doxorubicin (DOX) is a highly effective treatment for several forms of cancer. " 08/20/1997 - "Although doxorubicin remains one of the most effective agents for the treatment of solid tumors, there is an intensive effort to synthesize doxorubicin analogues (compounds with similar chemical structures) that may have improved antitumor properties. " Order ALL the reference details at left...
5.	Paclitaxel (Taxol)FDA LinkGeneric 07/14/2011 - "The microtubule-targeting antineoplastic agent, paclitaxel, is highly efficacious against a wide spectrum of human cancers. " 01/01/2011 - "Paclitaxel is highly effective in the treatment of many cancers in humans, but cannot be routinely used in dogs as currently formulated due to the exquisite sensitivity of this species to surfactant-solubilizing agents. " 01/01/2008 - "The development of paclitaxel resistance in tumors is one of the most significant obstacles to successful therapy. " 05/15/2006 - "The development of paclitaxel-resistance in tumors is one of the most significant obstacles to successful therapy. " 04/01/2005 - "The development of resistance to paclitaxel in tumors is one of the most significant obstacles to successful therapy. " Order ALL the reference details at left...
6.	Fluorouracil (Carac)FDA LinkGeneric 04/01/2004 - "Combined treatment with 5-FU and AxE1AdB-UPRT dramatically reduced the disseminated tumor burden without causing toxicity in normal tissues. " 06/30/2000 - "Effective treatment of certain cancers with 5-fluorouracil (5-FU) and irradiation is well established; however, the most effective combination of these agents remains controversial. " 09/01/1999 - "DPD activity is highly variable in cancer populations, and this variation may influence the antitumor efficacy of 5-fluorouracil. " 09/01/1987 - "To date, HDFA + 5-FU is one of the most effective treatments for large bowel cancer." 12/01/1975 - "For locally advanced, inoperable cancers, split-course technique, combined 5-FU and irradiation gave the best results, achieving longer palliation with improved quality of life and sometimes yielding cure (5-year survival)." Order ALL the reference details at left...
7.	Interleukin-2 (IL2)IBA 07/01/2005 - "Local interleukin 2 therapy is most effective against cancer when injected intratumourally." 11/20/1997 - "However, in a short-term therapy model, continued IL-2 expression was most effective against 3-day established tumors. " 03/23/1994 - "Because IL-2 does not have a direct effect on cancer cells but rather mediates its antitumor activity by altering host immune reactions, these data represent the best available evidence that immunologic therapy for cancer can be effective in selected patients." 04/07/1993 - "Our results suggest that induction of anti-tumor immune response by local IL-2 production is most effective when the helper cytokine is secreted by the tumor cell. " 01/01/1993 - "On the other hand, several groups have shown that application of intratumoral low doses of IL-2 can be highly effective against cancer and without toxic side-effects. " Order ALL the reference details at left...
8.	HormonesIBA 01/01/2011 - "Both of the primary investigations at our disposal, ultrasound and blood tests (adrenal hormones), helped in rendering the diagnosis and allowed us to move toward the most appropriate treatment, taking into account the size of the tumor and its probable hormonal production." 05/01/2009 - "C57BR/cdJ (BR) females are extremely susceptible to spontaneous and chemically induced liver tumors, in part due to a lack of protection against hepatocarcinogenesis normally offered by ovarian hormones. " 07/01/2005 - "Our in vitro results show that salicylhydrazides are highly potent compounds effective in both hormone receptor-positive and -negative cancer cells. " 11/01/2002 - "Whilst opinion remains divided on the best treatment for localized disease, intervention for metastatic, hormone-independent cancer remains extremely limited. " 02/01/1984 - "PSN research has yielded best results through the examination of those hormones produced by the tumor, esp. " Order ALL the reference details at left...
9.	VaccinesIBA 05/01/2001 - "Initial clinical trials with the HPV types which are most prevalent in cervical cancer exhibited promising results, yet next generation vaccines are already under development." 02/01/2012 - "While the development of anti-HPV prophylactic vaccines represents one of the most remarkable triumphs of modern medicine, there is much more to be done in terms of advancing safe and effective treatments for cervical and head-and-neck cancers. " 01/01/2012 - "Vaccines giving best protection against solid tumor growth corresponded to the archaeosome adjuvant composition that gave highest immune activity in immunized mice." 01/01/2012 - "Although recently developed vaccines protect vaccinated individuals from the two most carcinogenic HPV types, there is a pressing need for next-generation vaccines that might offer broad-spectrum protection against the full range of cancer-causing HPVs. " 05/01/2010 - "Development of safe and effective vaccines against human papillomavirus (HPV)-the second vaccine against a major human cancer-is one of the most important medical and public health achievements of this century. " Order ALL the reference details at left...
10.	AntibodiesIBA 07/01/2008 - "Importantly, most studies of EPO-R detection in tumor tissue have provided falsely positive results because of the lack of EPO-R specific antibodies. " 06/01/1991 - "2) In an animal model on tumor localization and biodistribution studies, CEA-specific antibodies obtained more highly tumor targeting and cleared more rapidly from the blood and non-tumor organs than CEA-nonspecific antibodies did, so that tumor to nontumor ratios was increased. " 12/01/2012 - "Blockade of Olfml3 by anti-Olfml3 antibodies is highly effective in reducing tumor vascularization, pericyte coverage, and tumor growth. " 11/01/2008 - "In an animal model, 1B2 obtained more highly tumor targeting and cleared more rapidly from the blood than the other two antibodies did. " 08/07/2006 - "A murine subrenal capsule fresh human tumor explant assay was utilized to test efficacy of various murine monoclonal anti-HER2 antibodies, and the data were helpful in choosing the most efficacious for subsequent human engineering for clinical use. " Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 01/01/2011 - "More recent trials have suggested that for advanced NSCLC patients with EGFR mutant tumors, initial therapy with a TKI instead of chemotherapy may be the best choice of treatment. " 04/01/1991 - "These results suggest that chemotherapy can be administered during pregnancy, even during the first trimester, because it is not hazardous to the fetus; nevertheless, this study is inadequate in size to exclude the possibility of teratogenesis, and more reports are necessary to define the best treatment from cancer during pregnancy." 11/01/1990 - "From maturing data in retrospective reviews, preliminary data from prospective trials, and recent well-conducted animal studies, chemotherapy and hormonal deprivation appear most effective when tumor volumes are the smallest. " 09/01/2012 - "With the increasing availability of highly effective chemotherapy, surgery may be further advanced by the improved tumor response and better long-term outcomes associated with its use in the perioperative setting. " 02/01/2012 - "While chemotherapy remains the most effective treatment for disseminated tumors, acquired or intrinsic drug resistance accounts for approximately 90% of treatment failure. " Order ALL the reference details at left...
2.	Radiotherapy 04/01/2012 - "Randomized multicenter controlled trials evaluating efficacy of conservation surgery and definitive radiotherapy, and correctly interpreting functional outcome for each of the treatment procedures examined are necessary to obtain sufficient evidence to influence the decision in the choice of the most effective treatment for early pyriform sinus cancer." 04/01/2012 - "The results will raise the profile of radiotherapy in the European cancer management context and help countries prioritizing radiotherapy as a highly cost-effective treatment strategy. " 01/01/2012 - "This is an updated version of the original Cochrane review published in The Cochrane Library 2009, Issue 3. Most women with early cervical cancer (stages I to IIA) are cured with surgery or radiotherapy, or both. " 09/01/2011 - "Radiotherapy is the most significant non-surgical cure for the elimination of tumor, however it is restricted by two major problems: radioresistance and normal tissue damage. " 04/01/2011 - "The most widely held explanation for the efficacy of local radiotherapy (RT) is based on direct cytotoxicity to cancer cells through the induction of lethal DNA damage. " Order ALL the reference details at left...
3.	Heterologous Transplantation (Xenotransplantation) 12/01/2012 - "Herein, we propose a hypothesis based on this novel conception that if transplanted as an organ, tumor implantation in nude mice would conserve most approximated biological traits with improved success rate, which make personalized tumor xenograft model practical for pre-clinical trials as substitutes for each patient. " 12/01/2012 - "Additionally, an upregulation of ENTPD5 in both GBM mouse xenografts and in GBM patient tumors was identified, resulting in dramatically reduced survival. " 07/01/2012 - "Xenograft mouse models demonstrated that γδ T cells dramatically reduced the tumor burden. " 12/01/2011 - "This novel agent is highly efficacious in cells with demonstrable resistance to the parent agent, including in solid tumor xenografts. " 09/01/2011 - "The Novel HSP90 inhibitor, IPI-493, is highly effective in human gastrostrointestinal stromal tumor xenografts carrying heterogeneous KIT mutations." Order ALL the reference details at left...
4.	Immunotherapy 09/01/2005 - "This study shows that DC maturation with cytokine cocktails different from those most commonly used could be beneficial for immunotherapy trials in cancer patients." 01/01/2004 - "DC-based immunotherapy has shown early promise in clinical cancer trials, and efforts are being made to determine the optimal method of delivery of cells to achieve the best outcome. " 07/01/2012 - "They are now being considered as prospective candidates in cancer immunotherapy because of their striking immune-enhancing impact on various effector elements of anti-tumour immunity on one hand, and to augment the efficacy of different anti-cancer immunotherapeutic strategies on the other. " 01/01/2012 - "Despite these advances, however, the efficacy of most cancer immunotherapies currently under clinical development has been modest. " 12/01/2011 - "The symptoms were dramatically relieved by tumor resection and immunotherapy." Order ALL the reference details at left...
5.	Therapeutics 11/01/2011 - "The identification of G36 as a GPER antagonist with improved ER counterselectivity represents a significant step towards the development of new highly selective therapeutics for cancer and other diseases." 06/01/2011 - "This targeted strategy holds promise in paving the way for the introduction of highly effective nanoscopic vehicles for cancer therapeutics while overcoming drug resistance." 01/01/2010 - "Intrinsic and acquired cellular resistance factors limit the efficacy of most targeted cancer therapeutics. " 08/01/2008 - "The past decade has witnessed the unveiling of a powerful new generation of genetically engineered mouse (GEM) models of human cancer, which are proving to be highly effective for elucidating cancer mechanisms and interrogating novel experimental therapeutics. " 01/01/2012 - "As yet no clinical trials have proven the efficacy of M3 antagonists as cancer therapeutics, though the widespread clinical use and low toxicity of M3 antagonists support the potential role of these drugs as adjuvants to current cancer therapies." Order ALL the reference details at left...

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