Nogo Receptor 1

A high affinity receptor for myelin-associated inhibitors (MAIs) that include NOGO-A PROTEIN; OLIGODENDROCYTE MYELIN GLYCOPROTEIN; and MYELIN-ASSOCIATED GLYCOPROTEIN. It is expressed primarily by neurons in the brain and OLFACTORY BULBS. During embryonic development, it is expressed in the PERIPHERAL NERVOUS SYSTEM. It localizes to GROWTH CONES and may inhibit neurite outgrowth following SPINAL INJURY.

Also Known As:

Networked: 68 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Strittmatter, Stephen M: 15 articles (01/2021 - 05/2003)
2.	Lee, Jae Young: 5 articles (01/2021 - 06/2012)
3.	Petratos, Steven: 5 articles (01/2021 - 06/2012)
4.	Kim, Ji-Eun: 4 articles (12/2008 - 10/2004)
5.	Tang, Bor Luen: 4 articles (08/2008 - 09/2004)
6.	Siatskas, Christopher: 3 articles (01/2021 - 06/2012)
7.	McGee, Aaron W: 3 articles (01/2018 - 12/2008)
8.	Liu, Betty P: 3 articles (12/2008 - 10/2004)
9.	Park, James H: 3 articles (12/2008 - 10/2004)
10.	Budel, Stephane: 3 articles (08/2005 - 11/2004)

Related Diseases

1.	Spinal Injuries (Spinal Injury) 05/01/2005 - "Transgenic inhibition of Nogo-66 receptor function allows axonal sprouting and improved locomotion after spinal injury." 05/01/2005 - "Axon growth after spinal injury is thought to be limited in part by myelin-derived proteins that act via the Nogo-66 Receptor (NgR). " 11/17/2004 - "Blockade of Nogo-66, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury."
2.	Spinal Cord Injuries (Spinal Cord Injury) 07/01/2014 - "Assessment of Nogo-66 receptor 1 function in vivo after spinal cord injury." 05/15/2014 - "Inhibition of Nogo-66 receptor (NgR) can promote recovery following spinal cord injury. " 04/15/2014 - "Bone marrow mesenchymal stem cells with Nogo-66 receptor gene silencing for repair of spinal cord injury." 01/01/2010 - "To determine whether Nogo-66 receptor (NgR) gene silencing in neural stem cells (NSCs) can ameliorate spinal cord injury (SCI) in rats. " 12/01/2008 - "Immunization with recombinant Nogo-66 receptor (NgR) promotes axonal regeneration and recovery of function after spinal cord injury in rats."
3.	Schizophrenia (Dementia Praecox) 09/30/2011 - "This study examined the association of the reticulon 4 receptor (RTN4R) gene with schizophrenia and smooth pursuit eye movement (SPEM) abnormality in a Korean population. " 07/01/2016 - "The protein NgR1 is encoded by RTN4R, a gene linked to schizophrenia. " 10/10/2011 - "To investigate the effects of missense mutation of the reticulon-4 receptor on phenotypes relevant to schizophrenia, we behaviourally characterized a novel Rtn4r mutant mouse line with an amino acid substitution (R189H) in the Nogo-66 binding site. " 04/22/2009 - "Converging evidence for the Nogo-66 receptor gene in schizophrenia." 12/03/2008 - "Mice lacking NgR1 protein exhibit reduced working memory function, consistent with a potential endophenotype of schizophrenia. "
4.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 12/01/2007 - "The objective of the study was to determine the effects of a hyaluronic-acid-based (HA-based) hydrogel implant, carrying a polyclonal antibody to the Nogo-66 receptor (NgR), on adult rats that underwent middle cerebral artery occlusion (MCAO). " 11/01/2022 - ": 3-MA: 3-methyladenine; ACTA2/ɑ-SMA: actin alpha 2, smooth muscle, aorta; AIF1/Iba1: allograft inflammatory factor 1; BafA1: bafilomycin A1; BMVECs: brain microvascular endothelial cells; BrdU: 5-bromo-2'-deoxyuridine; CLDN11/OSP: claudin 11; GFAP: glial fibrillary acidic protein; HUVECs: human umbilical vein endothelial cells; LAMA1: laminin, alpha 1; MAP2: microtubule-associated protein 2; MBP2: myelin basic protein 2; MCAO: middle cerebral artery occlusion; PDGFRB/PDGFRβ: platelet derived growth factor receptor, beta polypeptide; RECA-1: rat endothelial cell antigen-1; RHOA: ras homolog family member A; RHRSP: stroke-prone renovascular hypertensive rats; ROCK1: Rho-associated coiled-coil containing protein kinase 1; RTN4/Nogo-A: reticulon 4; RTN4R/NgR1: reticulon 4 receptor; S1PR2: sphingosine-1-phosphate receptor 2; SQSTM1: sequestosome 1."
5.	Epilepsy (Aura) 07/01/2021 - "The purpose of this study was to determine the dynamic changes of the Nogo-66 receptor 1 (NgR1) pathway during epileptogenesis and the potential beneficial of leucine-rich repeat and Ig-like domain-containing Nogo receptor interacting protein 1 (Lingo-1) inhibition on epilepsy rats. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Hydrogels
3.	Leucine (L-Leucine)
4.	Hyaluronic Acid (Hyaluronan)
5.	Nogo Receptors
6.	Carbon Nanotubes (Carbon Nanotube)
7.	Brain-Derived Neurotrophic Factor (BDNF)
8.	Peptides (Polypeptides)
9.	Myelin-Associated Glycoprotein
10.	Oligodendrocyte-Myelin Glycoprotein

Related Therapies and Procedures

1.	Transplantation
2.	Therapeutics
3.	Parenteral Infusions
4.	Immunotherapy