An experimental test of stroke recovery by implanting a hyaluronic acid hydrogel carrying a Nogo receptor antibody in a rat model.

Abstract	The objective of the study was to determine the effects of a hyaluronic-acid-based (HA-based) hydrogel implant, carrying a polyclonal antibody to the Nogo-66 receptor (NgR), on adult rats that underwent middle cerebral artery occlusion (MCAO). Behavioral tests of a forelimb-reaching task suggested that the disabled function of the impaired forelimb in this stroke model was ameliorated by the implant to a certain extent. These behavioral findings were correlated with immunohistochemical results of investigating the distribution of NgR antibody, neurofilaments (NF) and neuron-specific class III beta-tubulin (TuJ1) in the brain sections. The porous hydrogel functioned as a scaffold to deliver the NgR antibody, support cell migration and development. In addition, it was found NF-positive and TuJ1-positive expressions were distributed in the implanted hydrogel. Collectively, the results demonstrate the promise of the HA hydrogel as a scaffold material and the delivery vehicle of the NgR antibody for the repair of defects and the support of neural regeneration in the brain.
Authors	Jun Ma, Wei-Ming Tian, Shao-Ping Hou, Qun-Yuan Xu, Myron Spector, Fu-Zhai Cui
Journal	Biomedical materials (Bristol, England) (Biomed Mater) Vol. 2 Issue 4 Pg. 233-40 (Dec 2007) ISSN: 1748-605X [Electronic] England
PMID	18458480 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References	Antibodies, Monoclonal Drug Implants GPI-Linked Proteins Hydrogels Myelin Proteins Nogo Receptor 1 RTN4R protein, human Receptors, Cell Surface Hyaluronic Acid
Topics	Animals Antibodies, Monoclonal (administration & dosage, chemistry) Disease Models, Animal Drug Implants (chemistry) GPI-Linked Proteins Hyaluronic Acid (chemistry) Hydrogels (chemistry) Myelin Proteins (immunology) Nogo Receptor 1 Paresis (drug therapy, etiology) Rats Receptors, Cell Surface (immunology) Recovery of Function (drug effects) Stroke (complications, drug therapy) Treatment Outcome

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