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Tubulin

A microtubule subunit protein found in large quantities in mammalian brain. It has also been isolated from SPERM FLAGELLUM; CILIA; and other sources. Structurally, the protein is a dimer with a molecular weight of approximately 120,000 and a sedimentation coefficient of 5.8S. It binds to COLCHICINE; VINCRISTINE; and VINBLASTINE.

Also Known As:

alpha-Tubulin; beta-Tubulin; delta-Tubulin; epsilon-Tubulin; gamma-Tubulin; alpha Tubulin; beta Tubulin; delta Tubulin; epsilon Tubulin; gamma Tubulin

Networked: 1947 relevant articles (35 outcomes, 194 trials/studies) for this Bio-Agent, Comments

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hamel, Ernest: 19 articles (11/2012 - 10/2002)
2.	Dumontet, Charles: 13 articles (10/2012 - 05/2004)
3.	Kavallaris, Maria: 11 articles (11/2011 - 09/2002)
4.	Katsetos, Christos D: 9 articles (09/2012 - 12/2003)
5.	Panda, Dulal: 8 articles (02/2011 - 10/2002)
6.	Sève, Pascal: 7 articles (10/2012 - 02/2007)
7.	Dráber, Pavel: 7 articles (09/2012 - 08/2007)
8.	Brancale, Andrea: 7 articles (10/2011 - 12/2004)
9.	Jordan, Mary Ann: 7 articles (05/2010 - 05/2004)
10.	Dráberová, Eduarda: 6 articles (09/2012 - 08/2007)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2007 - "BM6, a new semi-synthetic vinca alkaloid, exhibits its potent in vivo anti-tumor activities via its high binding affinity for tubulin and improved pharmacokinetic profiles." 05/03/2004 - "Compounds inhibited tubulin polymerization with potencies commensurate with their cytotoxic activity and a more soluble anilino-containing analogue was very effective in inhibiting the growth of AR42J rat pancreatic tumors transplanted into in nude mice. " 02/01/2012 - "In tumors of treated animals, a significant reduction of Ki67, which was negatively correlated with tubulin acetylation, was observed. " 02/01/2001 - "Vascular targeting of solid tumors, using tubulin-compromising agents, seems a promising and selective novel treatment. " 06/01/2012 - "Thus, the aim of this study was to evaluate the effects of whitaphysalins on cancer cell cycle progression and tubulin interaction. " Order ALL the reference details at left...
2.	Breast Neoplasms (Breast Cancer) 02/01/2012 - "Measuring β-tubulin III, Bcl-2, and ERCC1 improves pathological complete remission predictive accuracy in breast cancer." 07/01/2011 - "In this study, we report, for the first time, an estimated value for the persistence length of a single non-neural microtubule polymerized from purified tubulin from human breast cancer cell lines (MCF7 tubulin). " 05/01/2011 - "We evaluated the prognostic and predictive utility of β-tubulin isotype III (TUBB3) tumour gene transcription in early breast cancer patients enrolled in a randomised study. " 05/01/2011 - "Prognostic utility of β-tubulin isotype III and correlations with other molecular and clinicopathological variables in patients with early breast cancer: a translational Hellenic Cooperative Oncology Group (HeCOG) study." 07/15/2008 - "In this study, we report for the first time that human breast tumor cells produce unique tubulin-based protrusions when detached from extracellular matrix. " Order ALL the reference details at left...
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 08/21/2012 - "Tubulin-binding agents (TBAs) are effective in non-small cell lung cancer (NSCLC) treatment. " 09/01/2012 - "Here we have determined by immunohistochemistry the localization and cellular distribution of γ-tubulin in clinical tissue samples from 109 non-small cell lung cancer (NSCLC) cases. " 09/01/2012 - "Overexpression of γ-tubulin in non-small cell lung cancer." 03/01/2011 - "[Relationship between the protein expression of ERCC1, BRCA, β-tubulin and K-ras and the efficacy and prognosis in advanced non-small cell lung cancer]." 07/01/2010 - "To explore the relationship between the expression of excision repair cross-complementation group 1 (ERCC1) and class III ß-tubulin and the clinical characteristics and overall survival of patients with non-small cell lung cancer (NSCLC). " Order ALL the reference details at left...
4.	Ovarian Neoplasms (Ovarian Cancer) 08/01/2012 - "Initial studies in breast, lung and ovarian cancers indicated aberrant expression of βV-tubulin, suggesting that this isoform may be associated with tumorigenesis. " 03/01/2012 - "The clinical value of these observations was tested by performing an archive study of 98 ovarian cancer patients, which demonstrated that the βIII-tubulin -/PIM1- cohort responded to treatment, exhibiting long overall survival (OS), while βIII-tubulin +/PIM+ patients experienced poor outcomes and OS times similar to patients receiving palliation alone. " 08/01/2012 - "BRCA1, a product of a familial breast and ovarian cancer susceptibility gene, localizes to centrosomes and physically interacts with γ-tubulin, a key centrosomal protein for microtubule nucleation and anchoring at centrosomes. " 03/01/2012 - "Class III β-tubulin and the cytoskeletal gateway for drug resistance in ovarian cancer." 07/15/2010 - "HuR regulates beta-tubulin isotype expression in ovarian cancer." Order ALL the reference details at left...
5.	Prostatic Neoplasms (Prostate Cancer) 12/01/2010 - "Tubulin III was expressed in the cytoplasm of prostate cancer cells but not in benign glands. " 12/01/2010 - "Beta-tubulin III expression in prostate cancer." 09/15/2009 - "At present, betaIII-tubulin expression remains largely uncharacterised in prostate cancer. " 07/01/2008 - "(Z)-1-1-Dichloro-2,3-diphenylcyclopropane (A(II)) and (Z)-1,1-dichloro-2-(4-methoxyphenyl)-3-phenylcyclopropane [2-(4-methoxyphenyl)-A(II)] inhibit tubulin polymerization, PSA production, and the proliferation of human prostate cancer cells. " 08/01/2007 - "The tubulin-inhibiting activity of this compound increases cytoplasmic AR levels in prostate cancer cells. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	Proteins (Proteins, Gene)
3.	taxane
4.	Vinca Alkaloids
5.	Prodrugs
6.	docetaxel (Taxotere)
7.	Vimentin
8.	Taxoids
9.	Cisplatin (Platino)
10.	Cytoskeletal Proteins

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Adjuvant Chemotherapy
4.	Lasers (Laser)
5.	Electroacupuncture

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