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dextrazide

a composition consisted of isoniazid and oxidized dextran

Networked: 7 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Shkurupy, V A: 7 articles (03/2021 - 12/2019)
2.	Kim, L B: 3 articles (03/2021 - 12/2019)
3.	Putyatina, A N: 3 articles (03/2021 - 12/2019)
4.	Russkikh, G S: 3 articles (03/2021 - 12/2019)
5.	Sinyavskaya, A M: 3 articles (02/2021 - 05/2020)
6.	Troitskii, A V: 3 articles (02/2021 - 03/2020)
7.	Kovner, A M: 2 articles (12/2020 - 05/2020)
8.	Troitskiy, A V: 1 article (05/2020)
9.	Bystrova, T N: 1 article (03/2020)
10.	Cherdantseva, L A: 1 article (03/2020)

Related Diseases

1.	Granuloma 05/01/2020 - "The antimycobacterial effect of dextrazide is an important factor preventing the destructive processes in granulomas and organs via a decrease in the prodestructive potential of lysosomes in macrophages realized after their migration from granulomas." 12/01/2020 - "Inhalations of liposome-encapsulated dextrazide prevented the destructive processes in liver granulomas due to macrophage migration from granulomas, which reduced granuloma sizes and destructive potential of granuloma lysosomes and therefore improved their diffusion-dependent trophics." 05/01/2020 - "Macrophages with captured mycobacteria tuberculosis, dextrazide, and dextrazide-loaded liposomes can be incorporated into granulomas. " 12/01/2020 - "Liposome-encapsulated dextrazide showed the maximum therapeutic efficiency: the total MBT level in granuloma macrophages and volume density of destruction foci in the liver parenchyma decreased by 5.1 and 5.3 times, respectively, in comparison with the corresponding parameters in mice treated with isonicotinic acid hydrazide. "
2.	Infections 12/01/2020 - "In 3 months after infection with Mycobacterium tuberculosis (MBT) from BCG vaccine, male BALB/с mice received intraperitoneal injections of isonicotinic acid hydrazide, dextrazide, or liposome-encapsulated dextrazide, or inhalation of liposome-encapsulated dextrazide 2 times a week for 6 months. " 02/01/2021 - "Administration of the liposome-encapsulated dextrazide (LEDZ) to mice 6 months after infection with mycobacterium BCG vaccine for 3 months modulated metabolism of collagens and the intensity of fibrosis of internal organs. " 02/01/2021 - "Three months after infection with Mycobacterium tuberculosis (MBT) from BCG vaccine, male BALB/с mice were treated with isonicotinic acid hydrazide, dextrazide (oxidized dextran), and liposome-encapsulated dextrazide intraperitoneally or in inhalations in a dose of 14 mg/kg (calculated for isoniazid) twice a week for 6 months. " 03/01/2021 - "The liposomal form of isonicotinic acid hydrazide conjugate with oxidized dextran (liposomeencapsulated dextrazide, LEDZ) injected intraperitoneally for 3 months to BALB/c mice with chronic BCG-induced granulomatosis (6 month after infection) down-regulated activities of protease (MMP) and antiprotease (TIMP-1, TIMP-2, α2-macroglobulin) components of the regulation system, which indicates a drop of destructive and inflammatory potential of BCGinduced granulomatosis. "
3.	Tuberculosis (Tuberculoses) 05/01/2020 - "Location of Pulmonary Mycobacteria Tuberculosis and Effectiveness of Various Dextrazide Compositions in Treatment of Mice with BCG-Induced Granulomatosis." 03/01/2020 - "Structural Changes in the Lungs and Liver of Mice with Experimental Tuberculosis Treated with Liposome-Encapsulated Dextrazide." 05/01/2020 - "Macrophages with captured mycobacteria tuberculosis, dextrazide, and dextrazide-loaded liposomes can be incorporated into granulomas. "
4.	Pulmonary Fibrosis (Fibrosing Alveolitis) 12/01/2019 - "This difference is explained by the fact both free and liposomal dextrazide activated MMP, but did not increase the content of TIMP-1 and TIMP-2, whereas injection of INH was followed by an increase in TIMP-2 content and a decrease in the level of free hydroxyproline, which attested to down-regulation of collagen degradation and maintenance of the conditions for pulmonary fibrosis in mice of this group."
5.	Fibrosis (Cirrhosis) 02/01/2021 - "Administration of the liposome-encapsulated dextrazide (LEDZ) to mice 6 months after infection with mycobacterium BCG vaccine for 3 months modulated metabolism of collagens and the intensity of fibrosis of internal organs. "

Related Drugs and Biologics

1.	Liposomes (Liposome)
2.	Isoniazid (Ftivazide)
3.	BCG Vaccine
4.	Matrix Metalloproteinases (MMPs)
5.	Dextrans (Dextran)
6.	Collagen
7.	Tissue Inhibitor of Metalloproteinase-2
8.	Tissue Inhibitor of Metalloproteinase-1
9.	Protease Inhibitors (Protease Inhibitor)
10.	Peptide Hydrolases (Proteases)

Related Therapies and Procedures

1.	Intraperitoneal Injections