HLA-DR alpha-Chains

Transmembrane proteins that form the alpha subunits of the HLA-DR antigens. They are also referred to as the HLA-DR heavy chains.

Also Known As:

HLA Class II Histocompatibility Antigen, DR alpha Chain; HLA-DR Heavy Chain; HLA-DRA; MHC Class II Antigen DRA; HLA DR Heavy Chain; HLA DR alpha; HLA DR alpha Chain; HLA DR alpha Chains; Heavy Chain, HLA-DR; alpha-Chain, HLA-DR; alpha-Chains, HLA-DR; HLA-DR alpha; HLA-DR alpha-Chain

Networked: 161 relevant articles (1 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bäckman, Anders: 3 articles (10/2017 - 10/2013)
2.	Cajander, Sara: 3 articles (10/2017 - 10/2013)
3.	Källman, Jan: 3 articles (10/2017 - 10/2013)
4.	Strålin, Kristoffer: 3 articles (10/2017 - 10/2013)
5.	Söderquist, Bo: 3 articles (10/2017 - 10/2013)
6.	Wang, Wei: 2 articles (06/2022 - 02/2020)
7.	Akhavan-Niaki, Haleh: 2 articles (07/2020 - 07/2020)
8.	Alinejad Rokni, Hamid: 2 articles (07/2020 - 07/2020)
9.	Asouri, Mohsen: 2 articles (07/2020 - 07/2020)
10.	Doosti, Rozita: 2 articles (07/2020 - 07/2020)

Related Diseases

1.	Adenocarcinoma 10/01/2016 - "Upregulation of HLA-DRA is significantly related to an increased disease-free and disease-specific survival in cervical adenocarcinoma. " 10/01/2016 - "In adenocarcinoma, HLA-DRA expression was associated with an increased disease-free survival (211.0 ± 13.0 vs 53.3 ± 30.5 months; P = 0.004) and disease-specific survival (226.45 ± 11.5 vs 75.8 ± 27.6 months; P = 0.002). " 10/01/2016 - "In squamous cell carcinoma, HLA-DRA was expressed in 41 (68.3%) of 60 tumors, whereas in adenocarcinoma, HLA-DRA was expressed in 60 (93.8%) of 64 tumors (P < 0.001). "
2.	Sepsis (Septicemia) 12/01/2019 - "In a second cohort, HLA-DRA expression was assessed in 80 patients with sepsis, 30 postoperative patients, and 44 healthy volunteers (German clinical trials database no. 00007694). " 01/01/2020 - "The dynamic changes in HLA-DRA expression in peripheral blood could accurately reflect the immune status of sepsis patients, and the reduction in HLA-DRA may be an important reason for abnormal T cell differentiation. " 01/01/2020 - "Dynamic changes in human HLA-DRA gene expression and Th cell subsets in sepsis: Indications of immunosuppression and associated outcomes." 12/01/2019 - "HLA-DRA expression was also significantly decreased in patients with sepsis at all time points (P = 0.004) compared with postoperative surgical patients, a finding confirmed in the larger cohort. " 01/01/2019 - "Quantifying the transcriptomic ratios MMP8/HLA-DRA, LCN2/HLA-DRA by ddPCR is a promising approach to improve sepsis diagnosis in surgical patients."
3.	Hypersensitivity (Allergy) 01/01/2015 - "HLA-DRA variants predict penicillin allergy in genome-wide fine-mapping genotyping." 05/01/1987 - "We utilized DNase I hypersensitivity mapping to study chromatin structure within the HLA-DR alpha gene. " 01/01/2015 - "HLA-DRA rs7192 and rs8084 were significantly associated with allergy to penicillins and amoxicillin (P = 6.0 × 10(-4) and P = 4.0 × 10(-4), respectively) but not to cephalosporins in the replication study. " 01/01/2016 - "The HLA-DRA variants are predictors of allergy to penicillins, but not to cephalosporins and they influence also the sensitization against prevalent allergens. " 01/01/2015 - "Gene variants of HLA-DRA and the HLA-DRA \| HLA-DRB5 interregion were significant predictors of allergy to penicillins but not to cephalosporins. "
4.	Neoplasms (Cancer) 07/06/2022 - "Furthermore, HLA-DRA was related to the features of inflamed TME in not only NSCLC but also in most cancer types. " 10/01/2016 - "These data warrant further analysis of the functional role of HLA-DRA in these tumors." 11/01/2011 - "VPA augmented the effects of GEM by enhancing the gene network mainly including HLA-DRA, possibly through the modification of cancer cell differentiation." 10/01/2004 - "We have now examined the expression of HLA-DR alpha chain in ovarian and a variety of other cancers using tissue arrays and found it overexpressed in a majority of the cancer tissues investigated. " 10/01/2004 - "Anomalous expression of the HLA-DR alpha and beta chains in ovarian and other cancers."
5.	Parkinson Disease (Parkinson's Disease) 04/01/2015 - "Many studies have evaluated the association between the HLA-DRA rs3129882 A/G polymorphism and risk for Parkinson's disease (PD) in Chinese-based populations, however, published data remain inconclusive. " 07/01/2021 - "The rs3129882/rs4248166 in HLA-DRA and rs34372695 in SYT11 are not associated with sporadic Parkinson's disease in Central Chinese population." 04/01/2015 - "HLA-DRA rs3129882 A/G polymorphism was not a risk factor for Parkinson's disease in Chinese-based populations: a meta-analysis." 01/01/2015 - "The common non-coding single nucleotide polymorphism (SNP) rs3129882 in HLA-DRA is associated with risk for idiopathic Parkinson's disease (PD). " 01/01/2015 - "Association analysis of HLA-DRA in Chinese patients with sporadic Parkinson's disease."

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	HLA-DR Antigens (HLA-DR)
3.	HLA Antigens (Human Leukocyte Antigens)
4.	HLA-DRB1 Chains (HLA DRB1)
5.	Proteins (Proteins, Gene)
6.	HLA-DM antigens (HLA-DMA)
7.	HLA-DPA1 antigen (HLA DPA1)
8.	HLA-DPB1 antigen (HLA DPB1)
9.	Interferon-gamma (Interferon, gamma)
10.	Biomarkers (Surrogate Marker)

Related Therapies and Procedures

1.	Therapeutics
2.	Cystectomy
3.	Prostatectomy (Retropubic Prostatectomy)
4.	Immunotherapy
5.	Aftercare (After-Treatment)