A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).
Also Known As:
ATP Binding Cassette Transporter, Subfamily B, Member 1; ABCB1 Protein; ATP Binding Cassette Transporter, Sub-Family B, Member 1; ATP-Binding Cassette, Sub-Family B, Member 1; CD243 Antigen; PGY-1 Protein; 1, P-Glycoprotein; ABCB1, ATP-Dependent Translocase; ATP Dependent Translocase ABCB1; Antigen, CD243; P Glycoprotein; P Glycoprotein 1; PGY 1 Protein; Protein, MDR1B; Translocase ABCB1, ATP-Dependent; ATP-Dependent Translocase ABCB1; MDR1 Protein; MDR1B Protein; Multidrug Resistance Protein 1; P-Glycoprotein; P-Glycoprotein 1