HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Amyloid (Amyloid Fibrils)

A fibrous protein complex that consists of proteins folded into a specific cross beta-pleated sheet structure. This fibrillar structure has been found as an alternative folding pattern for a variety of functional proteins. Deposits of amyloid in the form of AMYLOID PLAQUES are associated with a variety of degenerative diseases. The amyloid structure has also been found in a number of functional proteins that are unrelated to disease.

Also Known As:

Amyloid Fibrils; Amyloid Substance; Fibrils, Amyloid; Substance, Amyloid

Networked: 17744 relevant articles (343 outcomes, 1345 trials/studies) for this Bio-Agent, Comments

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Masters, Colin L: 54 articles (10/2012 - 01/2002)
2.	Blennow, Kaj: 49 articles (12/2012 - 01/2003)
3.	Holtzman, David M: 46 articles (12/2012 - 03/2002)
4.	Hyman, Bradley T: 43 articles (10/2012 - 02/2002)
5.	Zetterberg, Henrik: 35 articles (12/2012 - 04/2006)
6.	Trojanowski, John Q: 35 articles (11/2012 - 08/2002)
7.	Bush, Ashley I: 35 articles (11/2012 - 05/2002)
8.	Smith, Mark A: 33 articles (03/2012 - 01/2002)
9.	Masliah, Eliezer: 31 articles (02/2013 - 08/2002)
10.	Perry, George: 31 articles (08/2012 - 01/2002)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 07/01/2006 - "Most drug discovery efforts for Alzheimer's disease (AD) have focused on prevention or clearance of beta-amyloid (Abeta) fibrils or oligomers, with far less attention to prevention of tau abnormalities that lead to neurofibrillary tangles (NFTs). " 06/01/2010 - "This study deals with the structurally important intermediates and it may help to understand the mechanism of amyloid fibril aggregation leading to the onset of Alzheimer's disease." 06/01/2012 - "camphorata is proven to provide strong neuroprotection in neuron cells and suggested to have the potential of protection against neurotoxicity of amyloid β-protein (Aβ) known as the risk factor toward Alzheimer's disease (AD) development. " 01/13/2012 - "Accumulation of amyloid-beta (Aβ) is one of the hallmarks of Alzheimer's disease (AD), and efficient clearance of Aβ by cells of the innate immune system may be an important mechanism for controlling or preventing disease onset. " 01/01/2011 - "Compromised function of the choroid plexus and defective cerebrospinal fluid production and turnover, with diminished clearance of β-amyloid, may play an important role in late-onset forms of Alzheimer's disease. " Order ALL the reference details at left...
2.	Amyloidosis 07/31/1982 - "These observations support the view that major increases in SAA levels are a necessary condition for the deposition of this form of amyloid and suggest that prospective monitoring of the SAA concentration in predisposing diseases may help to identify those individuals who are most at risk for amyloidosis." 09/01/2003 - "Relapse occurred after 4 years of complete remission, and the second renal biopsy revealed amyloid light-chain (AL)-amyloidosis. " 12/01/2008 - "On the other hand, antioxidative intervention studies in animal models of AD-like amyloidosis show a significant reduction in amyloid beta deposition and behavioral improvements. " 09/01/2000 - "The serum HGF level was significantly elevated in both amyloid light-chain and amyloid A amyloidosis and was a very useful indicator of suspected amyloidosis as well as a potential prognostic indicator. " 12/01/1998 - "The difference in duration between pulmonary venous atrial reversal and mitral inflow A wave was significantly greater in the amyloidosis group compared with the normal group, and this index varied significantly within the amyloid group between the abnormal relaxation and the restrictive groups. " Order ALL the reference details at left...
3.	Amyloid Plaque 11/01/2004 - "Since active and passive immunization of amyloid precursor protein (APP) gene- transgenic mice showed significant reduction of beta amyloid deposits in the brain and the immunized mice showed improvement in cognitive functions, clinical trials were performed in US and Europe. " 01/01/2004 - "In the past two decades AD research has benefited significantly from the use of genetically engineered cell lines expressing components of the amyloid-generating pathway, as well as from the study of transgenic mice that develop the pathological hallmarks of the disease, mainly neuritic plaques. " 08/01/2012 - "The improved image resolution is sensitive enough to demonstrate an age-dependent increase of amyloid plaque load and a good correlation between the amyloid load measured by μMRI and histology. " 09/15/1987 - "Image analysis disclosed that the cross-sectional size of the large stromal amyloid deposits was significantly greater than those in age-matched patients with lattice corneal dystrophy type I. All patients had a discontinuous band of amyloid (15 to 25 micron wide) in the superficial stroma beneath Bowman's layer, which usually had only one or two small disruptions. " 04/01/2006 - "Better understanding of the mechanisms underlying amyloid formation has led to the development of novel treatment strategies aimed at inhibiting fibrillogenesis or destabilizing existing amyloid deposits. " Order ALL the reference details at left...
4.	Memory Disorders (Memory Loss) 06/29/2012 - "Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice." 07/01/2011 - "We found that the memory deficit in the AD mice was significantly improved by these treatments, but amyloid β deposition was unchanged. " 11/01/2011 - "The aim of this study is to evaluate the protective effects of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) on learning and (or) memory deficit in aged rats, as well as to explore the possible connection between TSG and the β-amyloid precursor protein (APP) pathway. " 07/01/2004 - "Mycelial extract of Cordyceps ophioglossoides prevents neuronal cell death and ameliorates beta-amyloid peptide-induced memory deficits in rats." 05/01/2004 - "Animal studies have been very encouraging in that both active and passive immunization of transgenic mice can reduce amyloid load and reverse memory deficits found in these mice. " Order ALL the reference details at left...
5.	Inflammation 04/01/2012 - "Importantly, an unchanged amyloid beta (Aβ) plaque load, an increase in soluble Aβ42 levels, and an aggravation of some behavioral parameters were noted, raising the question whether suppression of inflammation by nonsteroidal anti-inflammatory drug is beneficial in AD." 09/25/2008 - "This paper will give an overview on the protective effects of HupA, which includes regulating beta-amyloid precursor protein (APP) metabolism, protecting against Abeta-mediated oxidative stress, apoptosis and mitochondrial dysfunction, as well as anti-inflammation. " 06/01/1993 - "Prospective monitoring studies in patients whose JRA-associated inflammatory activity was in remission demonstrated regression of amyloid in 8 patients and no substantial changes in 8 others; however, in 4 further patients with active inflammation, there was accumulation of amyloid. " 05/01/2008 - "Overexpression of hNEP for 4 months in young APP/DeltaPS1 double-transgenic mice resulted in reduction in Abeta peptide levels, attenuation of amyloid load, oxidative stress, and inflammation, and improved spatial orientation. " 01/01/1988 - "In particular, the structure, synthesis and plasma clearance of the inflammation-associated amyloid precursor, SAA, have been extensively studied and the precursor-product relationship between circulating SAA, protein AA and fibrillar amyloid A clarified. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Peptides
2.	Antibodies
3.	Melphalan (Alkeran)
4.	Amyloid (Amyloid Fibrils)
5.	tau Proteins (tau Protein)
6.	Colchicine
7.	Proteins (Proteins, Gene)
8.	Amyloid Precursor Protein Secretases (beta-Secretase)
9.	Curcumin
10.	Amyloidogenic Proteins

Related Therapies and Procedures

1.	Immunotherapy
2.	Stem Cell Transplantation
3.	Therapeutics
4.	Transplants (Transplant)
5.	Lasers (Laser)

blog comments powered by Disqus

TREATMENT OPTIONS
for Alzheimer Disease,
Ranking and Evidence

CureHunter Patient-Physician Summary Reports collect in one document all the medications ever reported in the US National Library of Medicine—1949 to the present—to be effective against your target disease. Analytic charts allow you and your physicians to see at a glance the treatment options—including new, promising, off-label and experimental.

Free Updates for 1 Year
All 1332 Outcomes
Top 200 Key Drugs and Biologics
Top 50 Key Therapies and Procedures
Detailed History Charts
Full Research Evidence References
Sample PDF Report on Psoriasis >>

Price:

$24.95 USD & Delivery via PDF download
updates for 1 year

Research Interface PRO

Rapidly retrieve clinical outcome summaries for all evidence of drug efficacy against any disease in seconds. Click "Charts" to view graphs of relative efficacy of all drugs against any known disease. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time. Save hours of search and analysis time:

Two-clicks from Disease to Drug to Evidence: Drill down to full abstract
Enable Experts: Quickly identify key researchers and their publications
Enable FDA Link Generic: Two-clicks to FDA Products/Patents/Generics
Enable Export: All outcome statements and scores exportable to Excel/TSV for automated meta-analysis
Research Network: Explore drug and disease relationships visually
Enable Mobile Interface: Access from your cellphone, iPhone or PDA

Price:

$490.00 USD access via web interface
1 year subscription

Request Bulk Institution License Details >>