Lasalocid

Cationic ionophore antibiotic obtained from Streptomyces lasaliensis that, among other effects, dissociates the calcium fluxes in muscle fibers. It is used as a coccidiostat, especially in poultry.

Also Known As:

Avatec; Lasalocid A; Ro 2-2985; X-537A; Ro 2 2985; Ro 22985; X 537A; X537A; Benzoic acid, 6-(7-(5-ethyl-5-(5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)tetrahydro-3-methyl-2-furanyl)-4-hydroxy-3,5-dimethyl-6-oxononyl)-2-hydroxy-3-methyl-, (2R-(2alpha(2S*(3R*,4S*,5S*,7R*),3S*,5S*),5alpha,6beta))-

Networked: 137 relevant articles (23 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Huczyński, Adam: 4 articles (01/2022 - 09/2013)
2.	Page, Stephen W: 4 articles (09/2020 - 01/2015)
3.	Trott, Darren J: 4 articles (09/2020 - 01/2015)
4.	Garg, Sanjay: 3 articles (10/2018 - 01/2015)
5.	Antoszczak, Michał: 2 articles (01/2022 - 12/2020)
6.	Maj, Ewa: 2 articles (12/2020 - 09/2013)
7.	Wietrzyk, Joanna: 2 articles (12/2020 - 09/2013)
8.	Hickey, Elizabeth E: 2 articles (09/2020 - 10/2018)
9.	Wong, Hui San: 2 articles (10/2018 - 01/2015)
10.	Song, Yunmei: 2 articles (08/2017 - 01/2015)

Related Diseases

1.	Coccidiosis 09/01/1986 - "At 0.50, 0.75, or 1 mg/kg/day, lasalocid was equally effective in preventing induced coccidiosis (E bovis and E zuernii) in calves. " 12/01/2008 - "Efficacy of lasalocid against coccidiosis in Chinese ring-necked pheasants." 01/01/1985 - "Despite the fact that on some farms sub-clinical coccidiosis was diagnosed, the production performance clearly improved with lasalocid. " 06/01/2013 - "The purpose of this study was to gather data on the safety of lasalocid when fed to Chinese ring-necked pheasants at one, two, and three times the recommended high dose of lasalocid used for prevention of coccidiosis in other poultry at three times the normal treatment period. " 01/01/2012 - "Lasalocid is a polyether ionophoric coccidiostat used for the prevention of coccidiosis in poultry at a prescribed concentration and during a certain time interval. "
2.	Infections 08/01/2017 - "Lasalocid may be useful in the treatment of MRSP infections if in vivo studies support safety and efficacy." 12/01/1993 - "Therapeutically, lasalocid eliminated established overt infections of the intestine, although infection persisted in the common bile duct and intestinal infection recurred after lasalocid treatment was stopped. " 01/01/1995 - "It is concluded that mixing lasalocid in milk replacer (or fresh milk) is an effective method of protecting young calves against early infection with coccidia." 06/15/1992 - "Effects of lasalocid on coccidial infection and on calf growth were examined in 16 Holstein bull calves. " 06/15/1992 - "Effects of lasalocid on coccidial infection and growth in young dairy calves."
3.	Body Weight (Weight, Body) 04/01/2003 - "tenella supplementation with dietary oregano oil resulted in body weight gains and feed conversion ratios not differing from the non-infected group, but higher than those of the infected control group and lower than those of the lasalocid group. " 07/01/2001 - "Stair-step heifers supplemented with lasalocid had the highest efficiency of growth (body weight gain/dry matter intake), suggesting synergistic metabolism of lasalocid with compensatory growth action. " 01/01/1995 - "Four treatments were applied; lasalocid in milk (1 mg/kg body weight/day) (M), lasalocid in starter (F), lasalocid in both milk and starter (M + F) and untreated (C). " 06/15/1992 - "Mean daily gain, dry-matter intake, and body weight were increased in calves fed lasalocid and decreased in those inoculated with coccidia. " 03/01/1988 - "The lasalocid-fed group received lasalocid in milk at 1 mg/kg body weight daily from 4 to 7 d and at .5 mg/kg body weight daily in milk and medicated prestarter diet (88 mg lasalocid/kg) during the 2nd wk. After 2 wk, lasalocid-fed calves were given medicated prestarter and starter (44 mg lasalocid/kg) diets. "
4.	Weight Gain 10/01/1990 - "Lasalocid did not significantly influence the dry matter intake; daily weight gain and slaughtering results were increased (4.4 and 6.1%), energy efficiency was improved (3.8%). " 01/01/1981 - "Lasalocid for improved weight gains and control of Coccidia in lambs." 06/01/2013 - "Pheasant chicks (approximately 1 day-old; n = 160) were randomly blocked by sex into four treatment groups and given their respective diets continuously for 6 wk. No significant differences were observed in overall feed consumption, weight gain, feed conversion rates, clinical pathology measurements, or tissue gross and histopathologic evaluations between controls and treatment groups associated with lasalocid administration. " 08/01/1988 - "However, litter size and litter weight gains tended to be heavier at 21 d postfarrowing and at weaning for fall-bred sows fed lasalocid in either gestation and (or) lactation compared with those fed the control diet." 08/01/1988 - "The addition of lasalocid either to gestation or lactation diets had no effect (P greater than .10) on sow weight gains or days to return to estrus postweaning. "
5.	Cryptosporidiosis 07/04/2000 - "In vitro and in vivo efficacy of lasalocid for treatment of experimental cryptosporidiosis." 01/01/1996 - "For cryptosporidiosis, which can not be cured by a conventional symptomatic treatment, only Lasalocid-Na is available. " 10/11/2014 - "Administration of lasalocid-NA is preventive against cryptosporidiosis of newborn calves." 06/01/2005 - "[Cryptosporidiosis in newborn calves in Ankara region: clinical, haematological findings and treatment with Lasalocid-NA]." 06/01/2005 - "Treatment procedure in the present study with Lasalocid-Na was found to be suitable in combination with an adequate infusion therapy for the treatment of calves on farms with problems related to cryptosporidiosis. "

Related Drugs and Biologics

1.	Monensin (Coban)
2.	Ionophores
3.	salinomycin
4.	Sodium
5.	Decoquinate
6.	toltrazuril
7.	Nicarbazin
8.	halofuginone
9.	Amprolium
10.	Salts

Related Therapies and Procedures

1.	Therapeutics
2.	Off-Label Use
3.	Chemoprevention
4.	Protein-Restricted Diet (Diet, Protein Restricted)
5.	Injections

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