Interferon gamma Receptor

A heterodimeric receptor composed of two subunits IFNGR1 and IFNGR2. Activated IFNGR1 subunit is believed to form a docking site for SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1 (STAT1). IFNGR2 associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG).

Also Known As:

IFN-gammaR; 1, IFN-gamma Receptor; Antigen, CD119; Antigen, CDw119; IFN gamma Receptor 1; IFN gammaR; Protein, IFNGR2; Receptor 1, IFN-gamma; Receptors, Interferon gamma; gamma Receptor, Interferon; gamma Receptors, Interferon; CD119 Antigen; CDw119 Antigen; IFN-gamma Receptor 1; IFNGR2 Protein; Interferon gamma Receptor 2; Interferon gamma Receptors; Receptor, Interferon gamma

Networked: 276 relevant articles (8 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Cytokine Receptors: 1620
        Interferon Receptors: 126
        Interferon gamma Receptor: 276
        human IFNGR1 protein
        mouse Ifngr1 protein

Experts

1.	Casanova, Jean-Laurent: 7 articles (09/2010 - 03/2003)
2.	Casanova, J L: 7 articles (10/2001 - 01/2000)
3.	Holland, Steven M: 5 articles (08/2013 - 09/2004)
4.	Speck, Samuel H: 4 articles (01/2015 - 11/2005)
5.	Mora, Ana L: 4 articles (08/2010 - 11/2005)
6.	Rojas, Mauricio: 4 articles (08/2010 - 11/2005)
7.	Chapgier, Ariane: 4 articles (03/2010 - 03/2003)
8.	Hwang, Jung Hye: 4 articles (11/2007 - 04/2005)
9.	Kim, Eun Joo: 4 articles (11/2007 - 04/2005)
10.	Koh, Won-Jung: 4 articles (11/2007 - 04/2005)

Related Diseases

1.	Infections 08/01/1997 - "Within the past year, highlights include the mapping of a locus controlling the intensity of infection by Schistosoma mansoni, the demonstration that mutations in the interferon-gamma receptor 1 gene are causative of disseminated infection due to weakly pathogenic mycobacteria, and the identification, in the CCR5 gene, of a deletion which provides high protection against HIV-1 infection. " 08/01/1997 - "IFN-gammaR(-/-) mice cleared an infection with CS100 but were significantly more susceptible than control littermates to infection with C231 or TB521. " 12/01/2000 - "Infection in 129 mice was cleared between days 21 and 28 postchallenge, whereas infection in IFN-gammaR(-) mice was evident in 100% of animals from day 21 onward. " 08/03/1998 - "MCMV-infected IFN-gammaR-/- mice shed preformed infectious MCMV in spleen, peritoneal exudate cells, and salivary gland for up to 6 mo after infection, whereas the majority of congenic control animals cleared chronic productive infection. " 06/01/1997 - "IFN-gamma receptor-deficient (IFN-gammaR -/-) mice were used to study the innate immune responses during infection with Listeria monocytogenes. "
2.	Neoplasms (Cancer) 05/01/2003 - "We show in this study that CD8(+) effector T cells can reject tumors in bone marrow-chimeric mice incapable of cross-presenting Ag by bone marrow-derived APCs and that tumor rejection required host cells to express IFN-gammaR. " 01/01/2016 - "Interferon-Gamma Receptor Signaling Plays an Important Role in Restraining Murine Ovarian Tumor Progression." 03/01/2010 - "A defect in IFN-gammaR increased tumor growth, whereas tumor growth was inhibited in mice that were deficient in both IL-17R and IFN-gammaR compared with wild-type animals. " 10/15/2008 - "We observed that fewer NK cells infiltrated the tumors in IFN-gamma receptor knockout (IFN-gammaR(-/-)) mice compared with wild-type controls that correlated with decreased survival rate. " 01/15/2008 - "These findings suggest that coordinate downregulation of Fas and IFN-gammaR, 2 key components of cancer immunosurveillance system on tumor cells, leads to a more aggressive metastatic phenotype."
3.	Communicable Diseases (Infectious Diseases) 01/25/2002 - "To our knowledge, this is the first report of adenovirus-mediated IFN-gammaR gene transfer being effective in augmenting the biological activity of IFN-gamma, and the strategy employed in the present study will be useful in studying other kinds of cytokine receptors and applications to gene therapy for cancer and infectious diseases."
4.	Hypersensitivity (Allergy) 01/01/2005 - "We concluded that CXCL12 plays a central role in the pathogenesis of CIA in IFN-gammaR KO mice by promoting delayed type hypersensitivity against the auto-antigen and by interfering with chemotaxis of CXCR4+ cells to the inflamed joints. " 01/01/2001 - "Similarly, cutaneous delayed-type hypersensitivity, a typical Th1 response, was abolished in the IL-12-/-, mice but increased in the IFN-gammaR-/- mice. " 08/01/2000 - "Delayed type hypersensitivity-associated cytokines in islet xenotransplantation: limited efficacy of interleukin-2- and tumor necrosis factor-alpha-blockade in interferon-gamma receptor-deficient mice." 05/12/2009 - "Here we show that in naive animals spinal microglia express a receptor for the cytokine IFN-gamma (IFN-gammaR) in a cell-type-specific manner and that stimulating this receptor converts microglia into activated cells and produces a long-lasting pain hypersensitivity evoked by innocuous stimuli (tactile allodynia, a hallmark symptom of neuropathic pain). " 10/01/2008 - "We studied the polymorphisms in the interferon (IFN)-gamma (gamma) and IFN-gamma receptor 1 (IFNR1) gene with the aim of clarifying the relationships among these polymorphisms, penicillin allergy and anti-penicillin antibodies. "
5.	Reinfection 10/01/2009 - "Invasive and recurrent infections with these organisms have been associated with a genetic defect of the interferon gamma-receptor. " 10/01/1998 - "The development of nonprotective Th2 responses was observed in IFN-gammaR(-/-) mice upon mucosal infection and subsequent reinfection. " 03/01/1997 - "Following resolution of the primary infection and despite the augmented antibody responses to chlamydiae, the IFN-gammaR-/- mice were completely unprotected against reinfection, suggesting that local antibodies play a subordinate role in host protection against chlamydial infection. " 04/01/2001 - "Recurrent infection with this organism has been associated with a deletion at the 818 residue of the interferon-gamma receptor (IFN-gammaR). "

Related Drugs and Biologics

1.	Interferon-gamma (Interferon, gamma)
2.	Cytokine Receptors (Cytokine Receptor)
3.	Cytokines
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Nitric Oxide (Nitrogen Monoxide)
6.	Antibodies
7.	Proteins (Proteins, Gene)
8.	Interleukin-12 (IL 12)
9.	Ligands
10.	Interferons

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Therapeutics
3.	Investigational Therapies (Experimental Therapy)
4.	Hematopoietic Stem Cell Transplantation
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow)