Periostin

A multifunctional extracellular matrix protein that modulates CELL ADHESION to induce attachment to the EXTRACELLULAR MATRIX and CELL MIGRATION. It has a role INFLAMMATION and NEOPLASM METASTASIS

Also Known As:

Networked: 1288 relevant articles (54 outcomes, 267 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Izuhara, Kenji: 97 articles (10/2022 - 07/2006)
2.	Ono, Junya: 54 articles (10/2022 - 05/2011)
3.	Ohta, Shoichiro: 47 articles (12/2021 - 04/2007)
4.	Conway, Simon J: 32 articles (01/2022 - 12/2005)
5.	Kudo, Akira: 25 articles (04/2019 - 02/2008)
6.	Nunomura, Satoshi: 17 articles (10/2022 - 01/2017)
7.	Ouyang, Gaoliang: 17 articles (10/2021 - 04/2004)
8.	Arima, Kazuhiko: 16 articles (05/2018 - 07/2006)
9.	Yoshida, Shigeo: 15 articles (03/2020 - 07/2011)
10.	Matsumoto, Hisako: 14 articles (04/2021 - 08/2013)

Related Diseases

1.	Asthma (Bronchial Asthma) 05/01/2020 - "Serum periostin measurements may help to significantly improve the management of patients with severe asthma." 11/01/2018 - "Unlike serum periostin, which may be derived from several sources outside the lung, airways periostin is a useful marker of severe eosinophilic asthma and may help to phenotype patients that will respond to the biologic agents." 01/01/2023 - "A novel assay for improved detection of sputum periostin in patients with asthma." 01/01/2018 - "Understanding the mechanism of periostin production in BSM cells may help to clarify asthma pathogenesis." 11/01/2016 - "The diagnostic efficacy of periostin to detect uncontrolled asthma was analyzed using ROC analysis. "
2.	Fibrosis (Cirrhosis) 01/01/2017 - "UUO induced renal fibrosis and morphological changes in the obstructed kidney of wild-type mice, whereas global knockout of periostin reduced fibrosis induced by UUO and improved kidney structure. " 10/16/2023 - "A previous study revealed that periostin (POSTN) contributes to kidney fibrosis. " 01/01/2022 - "This study aims to verify the hypothesis that CREB promotes the expression of periostin in MI-induced myocardial fibrosis. " 08/01/2021 - "Previous studies support a role for periostin in lung fibrosis. " 07/01/2016 - "The present study investigated the importance of periostin in hypertension‑induced myocardial fibrosis. "
3.	Inflammation (Inflammations) 01/01/2021 - "The aim of the study was to determine the presence of periostin and evaluate its role as a non-invasive marker of allergic inflammation in the nasal secretions of children with atopic BA and AR. " 01/01/2018 - "This study examined the value of serum periostin, a marker of type 2 inflammation, as a measure of disease activity in patients with EGPA. " 02/01/2016 - "The aim of this study was to assess the effects of ICS on serum periostin levels and its relationships to inflammation and airway geometry. " 11/01/2012 - "The aim of this study was to explore the influence of chronic periodontal inflammation on tissue periostin levels. " 07/01/2012 - "In a recent study, periostin was found to directly regulate eosinophil accumulation in allergic mucosal inflammation. "
4.	Myocardial Infarction 02/01/2012 - "A recent study showed that periostin (PN) induced reentry of differentiated cardiomyocytes into the cell cycle and improved heart function after acute myocardial infarction (AMI). " 10/01/2013 - "Therefore, the objective of this study was to investigate the relationship between tissue periostin and cardiac variables in the chronic cardiac remodeling induced by myocardial infarction. " 01/01/2023 - "Serum periostin levels increase in acute myocardial infarction, and serum periostin can be used to predict cardiac function three months after acute myocardial infarction." 01/01/2023 - "There was an association between serum periostin at diagnosis and cardiac function three months after acute myocardial infarction: serum periostin was in negative correlation with ejection fraction (r = - 0.31, p = 0.028); positive association was found between serum periostin level and left ventricular end-diastolic diameter (r = 0.38, p = 0.006). " 01/01/2023 - "Serum periostin levels increased significantly in acute myocardial infarction patients compared with normal controls. "
5.	Neoplasms (Cancer) 11/01/2017 - "The in-depth study of periostin may provide an effective marker for tumor diagnosis and prognosis, as well as a novel treatment target." 07/01/2021 - "In recent years, studies have shown that periostin (POSTN) may regulate multiple biological behaviors of tumor cells. " 01/01/2020 - "The findings of the present study indicated that periostin secreted by cancer-associated stromal cells may be a potential therapeutic target for EOC." 01/01/2020 - "Serum periostin is associated with cancer mortality but not cancer risk in older home-dwelling men: A 8-year prospective analysis of the STRAMBO study." 01/01/2020 - "Previous studies have shown that the expression of periostin (POSTN) is significantly correlated with prognosis in multiple solid cancers. "

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	lebrikizumab
3.	Immunoglobulin E (IgE)
4.	Nitric Oxide (Nitrogen Monoxide)
5.	Interleukin-13
6.	Tenascin
7.	Proteins (Proteins, Gene)
8.	Cytokines
9.	Collagen
10.	Monoclonal Antibodies

Related Therapies and Procedures

1.	Therapeutics
2.	Peritoneal Dialysis
3.	Radiotherapy
4.	Chemoradiotherapy
5.	Low-Level Light Therapy (LLLT)