Gasdermins

A family of pore-forming effector proteins that cause membrane permeabilization and PYROPTOSIS.. Gasdermin-induced pyroptosis plays a prominent role in many HEREDITARY DISEASES and autoinflammatory disorders as well as in CANCER.

Also Known As:

Networked: 75 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lieberman, Judy: 6 articles (01/2022 - 01/2017)
2.	Liu, Xing: 6 articles (01/2022 - 01/2017)
3.	Zhang, Zhibin: 3 articles (01/2022 - 01/2021)
4.	Shi, Lin-Yang: 2 articles (03/2022 - 09/2021)
5.	Wang, Qing-Jun: 2 articles (03/2022 - 09/2021)
6.	Wang, Yuan-Yuan: 2 articles (03/2022 - 09/2021)
7.	Zhu, Zhi-Tu: 2 articles (03/2022 - 09/2021)
8.	Bai, Yang: 2 articles (01/2022 - 05/2020)
9.	Deng, Wanyan: 2 articles (01/2022 - 05/2020)
10.	Moreno-Bueno, Gema: 2 articles (01/2022 - 12/2021)

Related Diseases

1.	Inflammation (Inflammations) 08/03/2023 - "Here, we review the current knowledge on pyroptosis and human gasdermins, focusing on the description of the different members of the family, their molecular structures, and their influence on health and disease directly or non-directly related to inflammation. " 01/01/2022 - "The intestinal epithelial cells (IECs) of CBD treated mice demonstrated a transcriptional inhibition of a family of pyroptosis initiators that drive localized inflammation known as gasdermins (GSDMs). " 01/01/2022 - "Pyroptosis, a programmed cell death mediated by Gasdermins (GSDMs), is also considered to be an inflammatory cell death with links to inflammation. " 01/01/2021 - "Thus, gasdermins were originally thought to largely contribute to pathogen-induced inflammation. " 01/01/2021 - "Channelling inflammation: gasdermins in physiology and disease."
2.	Colitis 07/01/2023 - "Protective effects of IRG1/itaconate on acute colitis through the inhibition of gasdermins-mediated pyroptosis and inflammation response."
3.	Neoplasms (Cancer) 03/01/2022 - "Our previous study also found that gasdermins (GSDMs) was associated with the tumor immune microenvironment. " 08/28/2023 - "Gasdermins and cancers." 01/01/2023 - "However, despite the importance of gasdermins in the development of inflammatory diseases and cancer, a lot is still to be understood in the downstream consequences of this cell death pathway. " 01/01/2023 - "Although they are important for host antimicrobial defence, a growing body of evidence supports the notion that pyroptosis and gasdermins have pathological roles in cancer and several non-microbial diseases involving the gut, liver and skin. " 02/14/2022 - "A pan-cancer analysis of molecular characteristics and oncogenic role of gasdermins."
4.	Infections 11/28/2023 - "However, to date, we lack a comprehensive functional assessment of the different Gasdermins (GSDMA-E) during S.Tm infection in vivo. " 01/01/2021 - "Gasdermins were recently identified as the mediators of pyroptosis - inflammatory cell death triggered by cytosolic sensing of invasive infection and danger signals. " 01/01/2020 - "Emerging insights on the role of gasdermins in infection and inflammatory diseases." 01/01/2022 - "In this study, we assess the lytic functions of different gasdermins across Metazoa species, and use a mouse model of sepsis to evaluate the expression of the different gasdermins during infection. " 01/01/2020 - "These data suggest that gasdermins play a prominent role in innate immunity and autoinflammatory disorders, thereby providing potential new therapeutic avenues for the treatment of infection and autoimmune disease."
5.	Sepsis (Septicemia) 11/01/2023 - "Pyroptosis is a form of programmed cell death (PCD) executed by the gasdermins (GSDMs) family, and its pro-inflammatory characteristics are considered a crucial component of the sepsis mechanism. " 01/01/2023 - "Gasdermins in sepsis." 01/01/2022 - "In this study, we assess the lytic functions of different gasdermins across Metazoa species, and use a mouse model of sepsis to evaluate the expression of the different gasdermins during infection. "

Related Drugs and Biologics

1.	itaconic acid
2.	Proteins (Proteins, Gene)
3.	Inflammasomes
4.	Cytokines
5.	Caspases
6.	Peptide Hydrolases (Proteases)
7.	Perforin
8.	Phosphotransferases (Kinase)
9.	Complement System Proteins (Complement)
10.	Granzymes (Granzyme)

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy
3.	Drug Therapy (Chemotherapy)