An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.
Also Known As:
Eloxatin; 1,2-Diaminocyclohexane Platinum Oxalate; 1,2-Diamminocyclohexane(trans-1)oxolatoplatinum(II); ACT 078; ACT-078; Cis-oxalato-(trans-l)-1,2-diaminocyclohexane-platinum(II); Eloxatine; L-OHP Cpd; Oxalato-(1,2-cyclohexanediamine)platinum II; Oxaliplatin, (SP-4-2-(1R-trans))-isomer; Oxaliplatin, (SP-4-2-(1S-trans))-isomer; Oxaliplatin, (SP-4-3-(cis))-isomer; Oxaliplatine; Platinum(II)-1,2-cyclohexanediamine Oxalate; 1,2 Diaminocyclohexane Platinum Oxalate; ACT078; Platinum(2+) ethanedioate (1R,2R)-1,2-cyclohexanediamine (1:1:1)