Abstract | OBJECTIVE: METHODS: Clinical data of 71 patients with gastric cancer treated with oxaliplatin plus S-1 as adjuvant chemotherapy in the Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) from Jan 1(st), 2010 to Jan 1(st), 2012 were retrospectively reviewed. The types and incidence rate of adverse events related to chemotherapy and the results of follow up of the patients were analyzed. RESULTS: Among the 71 cases, 17 were treated with oxaliplatin biweekly, while 54 with oxaliplatin triweekly. The most common adverse events were neutropenia (n = 49, 69.0%), nausea/ vomiting (n = 51, 71.8%), and anorexia (n = 49, 69.0%). The most frequent grade 3-4 toxicities were neutropenia (n = 13, 18.3%), thrombocytopenia (n = 10, 14.1%), anorexia (n = 5, 7.0%) and nausea/ vomiting (n = 4, 5.6%). Seven (87.5%) of the 8 patients previously treated with neoadjuvant chemotherapy experienced thrombocytopenia in the postoperative adjuvant chemotherapy, and four (50%) of the 8 patients experienced grade 3-4 thrombocytopenia. The rates of grade 3-4 adverse events in patients aged 65-years or older were similar to that in younger patients. CONCLUSIONS:
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Authors | Yi Zhou, Jing Huang, Lin Yang, Yihebali Chi, Tao Qu, Xiao Lü, Jin-wan Wang |
Journal | Zhonghua zhong liu za zhi [Chinese journal of oncology]
(Zhonghua Zhong Liu Za Zhi)
Vol. 34
Issue 11
Pg. 860-4
(Nov 2012)
ISSN: 0253-3766 [Print] China |
PMID | 23291138
(Publication Type: Journal Article)
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Chemical References |
- Drug Combinations
- Organoplatinum Compounds
- Oxaliplatin
- S 1 (combination)
- Tegafur
- Oxonic Acid
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Topics |
- Adenocarcinoma
(drug therapy, pathology, surgery)
- Adult
- Aged
- Anorexia
(chemically induced)
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Chemotherapy, Adjuvant
- Drug Combinations
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Nausea
(chemically induced)
- Neoadjuvant Therapy
- Neoplasm Staging
- Neutropenia
(chemically induced)
- Organoplatinum Compounds
(administration & dosage, adverse effects)
- Oxaliplatin
- Oxonic Acid
(administration & dosage, adverse effects)
- Retrospective Studies
- Stomach Neoplasms
(drug therapy, pathology, surgery)
- Survival Rate
- Tegafur
(administration & dosage, adverse effects)
- Thrombocytopenia
(chemically induced)
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