Irinotecan (Camptosar)

A semisynthetic camptothecin derivative that inhibits DNA TOPOISOMERASE I to prevent nucleic acid synthesis during S PHASE. It is used as an antineoplastic agent for the treatment of COLORECTAL NEOPLASMS and PANCREATIC NEOPLASMS.

Also Known As:

Camptosar; CPT 11; SN 38; 7-Ethyl-10-hydroxycamptothecin; CPT-11; Camptothecin-11; Irinotecan Hydrochloride; Irrinotecan; NK012 Compound; SN 38 11; SN-38; SN-38-11; 7 Ethyl 10 hydroxycamptothecin; CPT11; Camptothecin 11; SN3811; (1,4'-Bipiperidine)-1'-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-9-yl ester

Networked: 7759 relevant articles (1266 outcomes, 2648 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Camptothecin: 2033
    - Irinotecan: 7759
      - folfirinox: 834
      - LA-SN38: 1

Experts

1.	Goldberg, Richard M: 44 articles (01/2021 - 01/2002)
2.	Falcone, Alfredo: 42 articles (11/2020 - 04/2002)
3.	Muro, Kei: 40 articles (03/2022 - 08/2003)
4.	Boku, Narikazu: 40 articles (01/2021 - 08/2000)
5.	Lenz, Heinz-Josef: 38 articles (10/2022 - 01/2003)
6.	Kim, Tae Won: 38 articles (11/2021 - 12/2004)
7.	Yamazaki, Kentaro: 37 articles (12/2021 - 07/2006)
8.	Yamada, Yasuhide: 37 articles (11/2021 - 01/2002)
9.	Komatsu, Yoshito: 34 articles (01/2022 - 06/2004)
10.	Ohtsu, Atsushi: 34 articles (01/2017 - 08/2000)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 11/21/2015 - "After irinotecan was introduced for the treatment of metastatic colorectal cancer (CRC) at the end of the last century, survival has improved dramatically. " 11/01/2001 - "Weekly CPT-11/5-FU/FA is highly effective in the treatment of patients with metastatic colorectal cancer limited to the liver, even after failure of previous 5-FU/FA. " 01/01/2008 - "This study aimed to determine the safety and efficacy of high-dose (HD) irinotecan combined with LV5FU2 or simplified LV5FU (LV5FUs) in first-line treatment of metastatic colorectal cancer. " 02/01/2011 - "Are we turning to more than a first line treatment of metastatic colorectal cancer with high dose irinotecan?: A monocentric institution safety analysis of 46 patients." 03/01/2008 - "No significant relationship was found between CES2 830C>G genotype and the toxicity and therapeutic efficacy (tumour response, event-free survival) of irinotecan in colorectal cancer patients. "
2.	Neoplasms (Cancer) 08/16/2004 - "The role of the UGT1A1 genotype as a predictor of toxicity in cancer patients receiving irinotecan demands the performance of a randomized trial to ascertain whether genotype-adjusted dosages of the drug can help to establish safe and effective doses not only for patients with the UGT1A1(*)28 homozygous genotype but also for those with the most common UGT1A1 6/6 or 6/7 genotype." 01/01/2022 - "Combination of hYP7-OKT3-hFc with Irinotecan dramatically improved the efficacy and arrested tumor growth of HepG2, Hep3B, and G1 in xenograft mice. " 01/01/2019 - "Background: SN38 (7-ethyl-10-hydroxy camptothecin), as a potent metabolite of irinotecan, is highly efficacious in cancer treatment. " 01/01/2017 - "In conclusion, nanocrystals dramatically enhanced the anticancer efficacy of SN-38 in vitro and in vivo, and the particle size had a significant influence on the dissolution behavior, pharmacokinetic properties, and tumor inhibition of nanocrystals." 03/01/2007 - "The chemotherapeutic agent irinotecan (IT) is highly effective against several types of cancer, although its use is limited due to severe intestinal toxicity. "
3.	Neoplasm Metastasis (Metastasis) 06/01/2017 - "Up to date, irinotecan is one of the most used chemotherapeutic agents to treat CRC metastasis with demonstrated efficacy. " 10/01/2010 - "NK012 eradicated the liver metastases and produced a significant longer survival rate than CPT-11 (P = 0.0006). " 11/01/2007 - "HAI (WHF: 1000 mg/m2) plus CPT-11 (100 mg/m2) was effective, and liver metastases showed a significant reduction (PR) on abdominal CT. " 01/01/2023 - "Irinotecan-loaded drug-eluting beads transarterial chemoembolization (DEBIRI-TACE) is a safe and effective therapeutic option for unresectable colorectal liver metastases (CRLM). " 11/01/2007 - "HAI plus CPT-11 was effective for a patient of the poor performance status with unresectable liver metastasis."
4.	Stomach Neoplasms (Stomach Cancer) 06/01/2007 - "CPT-11 appeared to be highly efficacious when given in combination with CDDP in human gastric cancer cell lines. " 03/01/2011 - "Irinotecan is inactive as a first-line treatment, but plays an important part in gastric cancer treatment." 01/15/2013 - "Overall survival benefits for irinotecan-containing regimens as first-line treatment for advanced gastric cancer: an updated meta-analysis of ten randomized controlled trials." 12/01/2007 - "The combination of 5-FU/LV and irinotecan as first-line treatment was found to be well tolerated and effective in patients with advanced gastric cancer. " 09/01/2005 - "S-1 with CPT-11 can be combined safely without CPT-11 effect on S-1 PK data and holds promise as an effective regimen for advanced gastric cancer."
5.	Colonic Neoplasms (Colon Cancer) 08/01/2004 - "l-LV/5-FU/low-dose CPT-11 seems to be effective for metastatic colon cancer, and safe from the toxicity standpoint." 05/01/1997 - "These results indicate that CPT-11 may play a role as radiosensitizer and that a combination of CPT-11 and irradiation could prove to be a particularly effective strategy with which to treat human colon adenocarcinoma." 12/01/2010 - "These data indicate that CG2 together with irinotecan is a promising combination novel treatment for colon cancer." 09/25/2020 - "The efficacy of empty and irinotecan-bearing systems was investigated in vitro on human colon cancer (HCT116) cell line, as well as in vivo, employing a xenograft mouse model of colon cancer. " 01/01/2019 - "Improved Efficacy and Reduced Toxicity Using a Custom-Designed Irinotecan-Delivering Silicasome for Orthotopic Colon Cancer."

Related Drugs and Biologics

1.	Fluorouracil (Carac)
2.	Oxaliplatin (Eloxatin)
3.	Leucovorin (Folinic Acid)
4.	Bevacizumab (Avastin)
5.	Irinotecan (Camptosar)
6.	Cetuximab (Erbitux)
7.	Cisplatin (Platino)
8.	Capecitabine (Xeloda)
9.	Gemcitabine
10.	folfirinox

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Combination Drug Therapy (Combination Chemotherapy)
4.	Radiotherapy
5.	Salvage Therapy