c-Mer Tyrosine Kinase

A receptor tyrosine kinase that transduces signals from EXTRACELLULAR MATRIX to the CYTOPLASM by binding ligands such as GALECTIN 3. It regulates many physiologic processes that include cell survival, migration, differentiation, and PHAGOCYTOSIS of apoptotic cells and ROD PHOTORECEPTORS in the RETINAL PIGMENT EPITHELIUM. Mutations in the MERTK gene are associated with type 38 RETINITIS PIGMENTOSA; it also plays a critical role as an inhibitor of TOLL-LIKE RECEPTORS signaling.

Also Known As:

Networked: 419 relevant articles (36 outcomes, 51 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Earp, H Shelton: 28 articles (01/2022 - 02/2003)
2.	Graham, Douglas K: 24 articles (01/2022 - 05/2010)
3.	Wang, Xiaodong: 21 articles (02/2022 - 05/2013)
4.	DeRyckere, Deborah: 20 articles (01/2022 - 05/2013)
5.	Frye, Stephen V: 18 articles (01/2022 - 05/2013)
6.	Tabas, Ira: 14 articles (01/2022 - 08/2008)
7.	Birge, Raymond B: 12 articles (01/2022 - 02/2008)
8.	Rothlin, Carla V: 11 articles (01/2022 - 08/2014)
9.	Davra, Viralkumar: 9 articles (01/2022 - 01/2016)
10.	Vollrath, Douglas: 9 articles (03/2016 - 01/2002)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2018 - "These observations suggest that therapeutic strategies cotargeting both AXL and MERTK could be highly beneficial in a variety of tumor types where both receptors are expressed, leading to improved survival for patients with lethal malignancies. " 01/01/2022 - "Furthermore, Mertk KO mice display improved anti-tumor immunity. " 02/01/2023 - "Our results indicated that the protocatechuate-TAASGVRSMH, thiazole-2-amido-TAASGVRSMH, and vanillate-TAASGVRSMH conjugates may be furthered developed for in vitro and in vivo studies as novel tumor targeting compounds for tumor cells over-expressing BRAF V600E, while di-theaninate-amido-TAASGVRSMH and thiazole-2-amido-TAASGVRSMH conjugates may be developed for targeting MERTK receptors. " 10/19/2022 - "Furthermore, similar to unconjugated anti-MerTK, PEGylated anti-MerTK antibody triggered type I IFN response and exhibited antitumor effect in syngeneic mouse tumor studies. " 01/01/2022 - "Studies are underway to develop small-molecule chemicals that inhibit MERTK as cancer immunotherapeutic agents, but these efforts are in their early stages. "
2.	Inflammation (Inflammations) 06/07/2016 - "We show here that SPM biosynthesis is increased and inflammation resolution is improved in a new mouse model in which endogenous MerTK was replaced with a genetically engineered variant that is cleavage-resistant (Mertk(CR)). " 11/18/2016 - "Our studies reveal that IL-37 limits runaway inflammation initiated by MSU crystal-induced immune responses, partly in a Mertk-dependent fashion. " 11/06/2023 - "Overall, these findings underscore the pivotal role of tissue-resident AMØs in resolving O 3 -induced inflammation via MerTK-mediated efferocytosis." 11/06/2023 - "Tissue-resident alveolar macrophages reduce O 3 -induced inflammation via MerTK mediated efferocytosis." 01/01/2023 - "Thus, inflammation drives severe, early-onset PR degeneration-associated with Mertk loss of function."
3.	Atherosclerosis 11/28/2020 - "Quantitative trait loci analyses in mice suggested candidate genes, including Mertk and Stab2, although how each gene affects the location-specific atherosclerosis needs further elucidation. " 01/01/2020 - "We recently demonstrated that the LMP7 subunit promotes diet-induced atherosclerosis via inhibition of MERTK-mediated efferocytosis. " 01/01/2020 - "In conclusion, we demonstrate that β5i plays an important role in diet-induced atherosclerosis by altering MERTK-mediated efferocytosis. " 01/01/2020 - "Immunoproteasome subunit β5i regulates diet-induced atherosclerosis through altering MERTK-mediated efferocytosis in Apoe knockout mice." 01/01/2017 - "DBA/2J Haplotype on Distal Chromosome 2 Reduces Mertk Expression, Restricts Efferocytosis, and Increases Susceptibility to Atherosclerosis."
4.	Fibrosis (Cirrhosis) 01/01/2019 - "These data suggest that SPP1hi macrophages contribute importantly to lung fibrosis in IPF, and that therapeutic strategies targeting MERTK and macrophage proliferation may show promise for treatment of this disease." 04/01/2022 - "MerTK activation in macrophages modifies the secretome to promote profibrogenic features in HSCs, implicating this receptor in the pathogenesis of hepatic fibrosis. " 09/13/2021 - "Most apoptotic bodies were engulfed by Ly6Clo macrophages, and this engulfment robustly triggered MMP12 expression for fibrosis resolution through the PtdSer-MerTK-ERK signaling pathway. " 10/27/2020 - "MerTK, a risk factor for NASH fibrosis." 01/01/2020 - "These data provide insights into the role of liver macrophages in NASH fibrosis and provide a plausible mechanism underlying MERTK as a genetic risk factor for NASH fibrosis."
5.	Non-alcoholic Fatty Liver Disease 09/30/2021 - "In parallel, the transcriptomic profiles of the injected MERTK+/hi M2c macrophages showed that the various genes directly or indirectly involved in NAFLD progression (e.g., SERPINE1, FADS2) were also suppressed. " 01/01/2019 - "By identifying specific targets influencing lipid metabolism and cardiovascular-related diseases, the present review highlights the role of MerTK in NAFLD-associated atherosclerotic lesions as a potential innovative therapeutic target. " 09/30/2021 - "Altogether, cell-based therapy using MERTK+/hi M2c macrophages is promising, as it ameliorates NAFLD in mice." 03/01/2016 - "The rs4374383 AA genotype, associated with lower intrahepatic expression of MERTK, is protective against F2-F4 fibrosis in patients with NAFLD. " 03/01/2016 - "The main study objective was to assess whether MERTK AA genotype influences liver fibrosis, and secondarily MERTK expression in patients with non-alcoholic fatty liver disease (NAFLD). "

Related Drugs and Biologics

1.	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)
2.	Phosphotransferases (Kinase)
3.	tyrosine receptor (receptor, tyrosine)
4.	Protein-Tyrosine Kinases (Tyrosine Kinase)
5.	c-Mer Tyrosine Kinase
6.	Ligands
7.	Interleukin-10 (Interleukin 10)
8.	Phosphatidylserines
9.	Lipopolysaccharides
10.	Leukocyte Elastase (Neutrophil Elastase)

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy
3.	Immunotherapy
4.	Transplantation
5.	Drug Therapy (Chemotherapy)