Chemokine CXCL16

A CXCR6 receptor-binding chemokine that functions as a scavenger receptor for oxidized low density lipoprotein (OxLDL) when expressed by MACROPHAGES. Its secreted, or cytokine form induces a strong chemotactic response for MONOCYTES when it is expressed by DENDRITIC CELLS.

Also Known As:

Networked: 92 relevant articles (0 outcomes, 14 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ludwig, Andreas: 5 articles (01/2016 - 06/2005)
2.	Kume, Noriaki: 5 articles (11/2011 - 05/2002)
3.	Kume, N: 5 articles (12/2001 - 12/2000)
4.	Li, Yan: 4 articles (01/2020 - 01/2014)
5.	Held-Feindt, Janka: 4 articles (10/2016 - 06/2005)
6.	Mentlein, Rolf: 4 articles (10/2016 - 06/2005)
7.	Hojo, Shozo: 4 articles (12/2014 - 05/2007)
8.	Koizumi, Keiichi: 4 articles (12/2014 - 05/2007)
9.	Saiki, Ikuo: 4 articles (12/2014 - 05/2007)
10.	Shimaoka, Takeshi: 4 articles (11/2011 - 02/2004)

Related Diseases

1.	Atherosclerosis 04/01/2008 - "Surprisingly, in vivo studies performed in murine models of atherosclerosis suggested that CXCL16/SR-PSOX is atheroprotective, while its receptor CXCR6 is harmful. " 04/01/2008 - "A series of studies conducted in the past few years described CXCL16/SR-PSOX--a new molecule combining those three functions, and suggested that CXCL16/SR-PSOX can be a potential player in atherogenesis. " 02/24/2014 - "The novel chemokine CXCL16 is known to be involved in the development of atherosclerosis. " 08/01/2011 - "In rabbit aorta immunocytochemistry revealed SR-PSOX/CXCL16 primarily in the endothelium at sites predisposed to lesion formation, in the endothelium of early atherosclerotic lesions, and mainly in intimal macrophages of more developed lesions, indicating that SR-PSOX/CXCL16-expression shifts during atherogenesis. " 04/01/2008 - "Such complex approach will help us unravel the mystery of CXCL16/SR-PSOX in atherosclerosis and hopefully develop better ways of treating atherosclerosis by targeting this interesting molecule."
2.	Inflammation (Inflammations) 10/31/2022 - "Transcriptome analysis of VSMCs revealed some differential downstream genes of TMEM16A related to inflammation, such as endothelial cell-specific molecule 1 (ESM1) and CXC chemokine ligand 16 (CXCL16). " 06/01/2012 - "Thus, TWEAK upregulates the expression of the chemokine CXCL16 in tubular epithelium and this may contribute to kidney tubulointerstitial inflammation." 11/01/2011 - "SR-PSOX/CXCL16 plays a critical role in colonic inflammation and could be a potential therapeutic target for patients with IBD." 11/01/2011 - "SR-PSOX/CXCL16 KO mice were less susceptible to colonic inflammation than were their WT littermates. " 11/01/2011 - "SR-PSOX/CXCL16 plays a critical role in the progression of colonic inflammation."
3.	Chronic Kidney Failure (Chronic Renal Failure) 01/01/2018 - "This study aimed to explore the role of Lpa in the progression of atherosclerosis in patients with end-stage renal disease (ESRD) and to investigate whether its potential mechanism is mediated by CXC chemokine ligand 16 (CXCL16) and low-density lipoprotein receptor (LDLr). " 01/01/2016 - "This study aimed to determine the effects of the CXC chemokine ligand 16 (CXCL16)/CXC chemokine receptor 6 (CXCR6) pathway on cholesterol accumulation in the radial arteries of end-stage renal disease (ESRD) patients with concomitant microinflammation and to further investigate the potential effects of the purinergic receptor P2X ligand-gated ion channel 7 (P2X7R). "
4.	Neoplasms (Cancer) 10/01/2023 - "Bacteria expressing an activating mutant of the human chemokine CXCL16 (hCXCL16K42A) offer therapeutic benefit in multiple mouse tumor models, an effect mediated via recruitment of CD8+ T cells. " 07/15/2013 - "The transmembrane chemokine CXCL16 is heavily expressed by tumor, microglial and endothelial cells in situ and in vitro. " 12/01/2012 - "Nuclear CXC chemokine ligand 16 expression correlated inversely with the depth of invasion, lymphatic invasion, Union Internationale Contre le Cancer stage, and favorable prognosis. " 04/01/2010 - "Up-regulation of the pro-inflammatory chemokine CXCL16 is a common response of tumor cells to ionizing radiation." 12/15/2007 - "In this context, SR-PSOX-deficient mice showed impaired sensitivity to alphaGalCer-induced anti-tumor effect mediated by IFN-gamma from NKT cells. "
5.	Coronary Artery Disease (Coronary Atherosclerosis) 04/01/2008 - "In addition, studies investigating the association of circulating CXCL16/SR-PSOX plasma concentrations with the presence and extent of coronary artery disease (CAD) in humans are controversial suggesting both positive, negative and no association. " 09/21/2022 - "Platelet SR-PSOX/CXCL16-CXCR6 Axis Influences Thrombotic Propensity and Prognosis in Coronary Artery Disease." 12/13/2011 - "To examine the level of circulating soluble CXC-chemokine ligand 16 (CXCL16) in different types of coronary artery disease and its association with severity of disease. " 10/01/2006 - "Decreased plasma CXCL16/SR-PSOX concentration is associated with coronary artery disease." 07/01/2008 - "The novel chemokine CXCL16 is involved in the development of atherosclerosis and coronary artery disease (CAD). "

Related Drugs and Biologics

1.	Scavenger Receptors (Scavenger Receptor)
2.	Chemokines
3.	Lipoproteins (Lipoprotein)
4.	Biomarkers (Surrogate Marker)
5.	Proteins (Proteins, Gene)
6.	Phosphatidylserines
7.	Lipids
8.	Purinergic P2X7 Receptors
9.	CXCR Receptors
10.	LDL Receptors (LDL Receptor)

Related Therapies and Procedures

1.	Therapeutics
2.	Carotid Endarterectomy