Abstract | BACKGROUND: METHODS: Using ELISA, we assayed the plasma CXCL16 concentration in 16 stable angina pectoris (SAP) patients, 53 acute coronary syndrome (ACS) patients, and 19 control patients. All patients underwent coronary angiography after admission. They were divided into four groups according to the quartile of CXCL16 level. Characteristics and the relationship between CXCL16 and the elements were studied in each group. RESULTS: CXCL16 levels in the ACS group were higher than controls and SAP group (p <0.01 vs. controls; p <0.05 vs. SAP group). Gensini score in the highest quartile group of CXCL16 level (group IV, CXCL16 >2.21 ng/mL) was significantly higher than in the lowest quartile group of CXCL16 level (group I, CXCL16 < or = 1.43 ng/mL) (p <0.001). Gensini score in group II (1.43 ng/mL <CXCL16 < or = 1.72 ng/mL) and group III (1.72 ng/mL<CXCL16 < or = 2.21 ng/mL) were also higher than in group I (p <0.05, p <0.01). In addition, CXCL16 level had a positive correlation with Gensini score (r = 0.519, p <0.001). CONCLUSIONS: CXCL16 levels are positively associated with the severity of coronary artery stenosis. Activity level of CXCL16 in human plasma appears to be a good biomarker for epidemiological and clinical application in CAD.
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Authors | Gui-Wen Yi, Qiu-Tang Zeng |
Journal | Archives of medical research
(Arch Med Res)
Vol. 39
Issue 5
Pg. 531-5
(Jul 2008)
ISSN: 0188-4409 [Print] United States |
PMID | 18514099
(Publication Type: Journal Article)
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Chemical References |
- CXCL16 protein, human
- Chemokine CXCL16
- Chemokines, CXC
- Receptors, Scavenger
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Topics |
- Acute Disease
- Adult
- Aged
- Aged, 80 and over
- Angina Pectoris
(blood)
- Chemokine CXCL16
- Chemokines, CXC
(blood)
- Coronary Stenosis
(blood, pathology)
- Humans
- Male
- Middle Aged
- Receptors, Scavenger
(blood)
- Risk Factors
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