Fertilins

Sperm surface proteins involved in sperm-egg fusion. They consist of two subunits, fertilin alpha (ADAM1a) and beta (ADAM2), both of which belong to the metalloprotease-disintegrin protein family. The beta subunit does not have catalytic activity.

Also Known As:

ADAM 1a Protein; ADAM 2 Protein; ADAM1 Protein; ADAM1a Protein; ADAM2 Protein; Fertilin; Fertilin Protein; Fertilin alpha; Fertilin beta; PH 30 Fusion Protein; PH-30 Fusion Protein; PH-30 Protein; PH-30 alpha; PH-30 beta; PH 30 Protein; PH 30 alpha; PH 30 beta; alpha, Fertilin; alpha, PH-30; beta, Fertilin; beta, PH-30

Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bourmenskaya, O V: 1 article (08/2012)
2.	Donnikov, A E: 1 article (08/2012)
3.	Kalinina, E A: 1 article (08/2012)
4.	Krasnoschoka, O E: 1 article (08/2012)
5.	Smolnikova, V Yu: 1 article (08/2012)
6.	Sukhikh, G T: 1 article (08/2012)
7.	Trofimov, D Yu: 1 article (08/2012)
8.	Ikawa, Masahito: 1 article (10/2002)
9.	Moss, Stuart B: 1 article (10/2002)
10.	Nakanishi, Tomoko: 1 article (10/2002)

Related Diseases

1.	Infertility (Sterility) 01/01/1996 - "In a pilot fertility trial, immunization of male guinea pigs with purified guinea pig fertilin resulted in complete infertility. " 10/01/2022 - "Male partners of couples with unexplained infertility showed a low distribution of fertilin β by a decrease of the fluorescence signal in the IF labeling (scale of +++ by 7.4±10.32%, P<0.0001, ±SD). " 10/15/2002 - "The cause of the sterility initially was considered to be impaired abilities in sperm/zona pellucida (ZP) and sperm/egg plasma membrane (EPM) binding, and in the ascension of sperm to the oviduct, phenotypes similar to those seen in sperm from fertilin beta-deficient animals. " 10/12/1999 - "These findings correlate with the observation that fertilin beta "knockout" sperm traverse the uterus but do not progress into the oviduct, contributing to the infertility of fertilin beta(-/-) male mice. " 10/01/2022 - "We suggest that the relationship between infertility and fertilin β may be due to the distribution of this protein on the sperm surface. "
2.	Herpes Zoster 09/18/1998 - "Fertilin could also have a direct role in sperm-zona binding or oviduct migration; alternatively, the effects on these functions could result from the absence of fertilin activity during spermatogenesis." 05/01/1999 - "We evaluated whether fertilin beta plays a role in human fertilization by studying the effects of a linear octapeptide containing the FEE sequence, SFEECDLP, and a scrambled octapeptide with the same amino acids, SFPCEDEL, on the incorporation of human spermatozoa by human zona-free eggs. " 02/01/1999 - "Fertilin beta peptides inhibit sperm binding to zona-free eggs in a homologous baboon in vitro fertilization system." 02/01/1999 - "Micromolar quantities of hexapeptides or a 28 aa residue peptide, all corresponding to fertilin beta disintegrin domain, competitively inhibited the binding of zona-free baboon eggs by baboon sperm in vitro. " 10/01/1997 - "Preincubation of rabbit sperm with these anti-fertilin IgG antibodies at concentrations of 400 micrograms/ml blocked sperm binding to zona-intact oocytes and inhibited fertilization in vitro by 60-80%. "

Related Drugs and Biologics

1.	Disintegrins
2.	Peptides (Polypeptides)
3.	Integrins
4.	Messenger RNA (mRNA)
5.	Proteins (Proteins, Gene)
6.	Protamines (Protamine Sulfate)
7.	Immunoglobulin G (IgG)
8.	Antibodies
9.	Amino Acids