Lumican

A small leucine-rich proteoglycan that contains 10 tandem leucine repeats and four N-linked sites within the leucine repeat region that may be substituted with KERATAN SULFATE. These properties and its horseshoe shape allow it to mediate interactions among COLLAGEN molecules within fibrils. It is expressed in most mesenchymal tissues as well as the CORNEA, where it functions to maintain transparency.

Also Known As:

Networked: 260 relevant articles (8 outcomes, 70 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Brézillon, Stéphane: 21 articles (11/2021 - 12/2007)
2.	Ishiwata, Toshiyuki: 15 articles (08/2014 - 03/2002)
3.	Naito, Zenya: 15 articles (08/2014 - 04/2002)
4.	Chakravarti, Shukti: 14 articles (01/2021 - 09/2002)
5.	Maquart, François-Xavier: 12 articles (01/2019 - 06/2004)
6.	Wegrowski, Yanusz: 12 articles (01/2016 - 06/2004)
7.	Perreau, Corinne: 11 articles (01/2017 - 06/2004)
8.	Kao, Winston W-Y: 9 articles (11/2021 - 12/2007)
9.	Karamanou, Konstantina: 8 articles (09/2021 - 01/2016)
10.	Yamamoto, Tetsushi: 8 articles (11/2018 - 09/2007)

Related Diseases

1.	Insulin Resistance 12/01/2022 - "Lumican knockdown in adipocytes decreased lipolysis and improved adipogenesis and insulin sensitivity in VAT adipocytes in DM, while treatment with human recombinant lumican increased lipolysis and impaired insulin-sensitivity in an ERK-dependent manner. " 01/01/2019 - "Lumican over-expression in visceral fat and liver resulted in improved insulin sensitivity and glucose clearance. " 01/01/2019 - "Lumican null female mice exhibited moderately increased fat mass, decreased insulin sensitivity and increased liver triglycerides in a diet-dependent manner. " 12/01/2022 - "Lumican is a proteoglycan implicated in obesity, insulin resistance (IR), and adipocyte dysfunction. "
2.	Neoplasms (Cancer) 11/18/2010 - "Therefore, this study is the first to demonstrate a causal relationship between tumor reduction and lumican's effect on angiogenesis as opposed to an effect on the cancerous cells themselves." 01/01/2023 - "Multi-omics analysis reveals the prognostic and tumor micro-environmental value of lumican in multiple cancer types." 01/01/2023 - "Lumican expression levels were significantly higher in pancreatic tumor tissues relative to healthy paracancerous tissues. " 11/26/2021 - "Analysis of tumor volumes demonstrated an inhibitory effect of endogenous lumican on ovarian tumor growth. " 11/26/2021 - "Assessment of Ovarian Tumor Growth in Wild-Type and Lumican-Deficient Mice: Insights Using Infrared Spectral Imaging, Histopathology, and Immunohistochemistry."
3.	Adenocarcinoma 03/01/2013 - "The present study was aimed to investigate lumican expression in and correlation with severity of pancreatic ductal adenocarcinoma (PDA). " 01/01/2023 - "As such, we evaluated the functional importance of lumican in the context of pancreatic ductal adenocarcinoma (PDAC) to understand its mechanistic role in PC. " 01/01/2021 - "Lumican inhibits immune escape and carcinogenic pathways in colorectal adenocarcinoma." 01/01/2017 - "We previously demonstrated that pancreatic stellate cells within pancreatic ductal adenocarcinoma (PDAC) stroma secrete lumican and its presence is associated with prolonged survival of patients with localized PDAC. " 01/01/2017 - "Prolonged exposure to extracellular lumican restrains pancreatic adenocarcinoma growth."
4.	Fibrosis (Cirrhosis) 09/22/2015 - "These data may explain why fibrocytes are increased in fibrotic tissues, suggest that the levels of lumican in tissues may have a significant effect on the decision of monocytes to differentiate into fibrocytes, and indicate that modulating lumican signaling may be useful as a therapeutic for fibrosis. " 05/01/2001 - "In the present study, the expression and role of lumican in fibrosis of an ischemic and reperfused rat heart were examined. " 11/01/2020 - "Lumican promotes joint fibrosis through TGF-β signaling." 12/01/2018 - "The finding that lumican is raised in HCM hearts provides insight into the myocardial fibrosis that characterizes this disease." 01/01/2018 - "Our results showed that the PDL-differentiated CSK-like cells expressed CSK markers (CD34, ALDH3A1, keratocan, lumican, CHST6, B3GNT7 and Col8A2) and had minimal expression of genes related to fibrosis and other lineages (vasculogenesis, adipogenesis, myogenesis, epitheliogenesis, neurogenesis and hematogenesis). "
5.	Colonic Neoplasms (Colon Cancer) 11/01/2012 - "The aim of this study was to determine the effect of lumican overexpression on the migration ability of human colon adenocarcinoma LS180 cells. " 11/01/2012 - "These data suggest that lumican expression and its presence in ECM has an impact on colon cancer cells motility and may modulate invasiveness of colon cancer." 01/01/2016 - "The aim of this work was to investigate lumican effects on MMP-14 activity and migration of Snail overexpressing B16F1 (Snail-B16F1) melanoma cells and HT-29 colon adenocarcinoma cells. " 12/01/2013 - "Lumican and versican are associated with good outcome in stage II and III colon cancer." 11/01/2012 - "Overexpression of lumican affects the migration of human colon cancer cells through up-regulation of gelsolin and filamentous actin reorganization."

Related Drugs and Biologics

1.	Versicans (Versican)
2.	Biomarkers (Surrogate Marker)
3.	Glucose (Dextrose)
4.	Decorin
5.	Proteins (Proteins, Gene)
6.	Messenger RNA (mRNA)
7.	Proteoglycans (Proteoglycan)
8.	Biglycan
9.	Fibromodulin
10.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Therapeutics
2.	Chemoradiotherapy
3.	Aftercare (After-Treatment)
4.	Cell- and Tissue-Based Therapy (Cell Therapy)
5.	Artificial Respiration (Mechanical Ventilation)