Member 2 Subfamily G ATP Binding Cassette Transporter

ATP-binding cassette transporter, sub-family G protein that functions as a high capacity UREA exporter, transporter of STEROLS, and in the absorption and efflux of many drugs. Its efflux activity for ANTINEOPLASTIC AGENTS contributes to DRUG RESISTANCE. It functions as a homodimer and is expressed by cells in a variety of organs, as well as by NEOPLASTIC STEM CELLS.

Also Known As:

Networked: 108 relevant articles (5 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wang, Jing-Quan: 7 articles (05/2022 - 11/2020)
2.	Chen, Zhe-Sheng: 6 articles (05/2022 - 01/2021)
3.	Wu, Zhuo-Xun: 6 articles (05/2022 - 11/2020)
4.	Teng, Qiu-Xu: 5 articles (05/2022 - 11/2020)
5.	Yang, Yuqi: 5 articles (05/2022 - 11/2020)
6.	Ashby, Charles R: 5 articles (02/2021 - 01/2016)
7.	Narayanan, Silpa: 4 articles (09/2021 - 01/2021)
8.	Matsuo, Hirotaka: 4 articles (07/2020 - 01/2014)
9.	Takada, Tappei: 4 articles (07/2020 - 01/2014)
10.	Sarkadi, Balázs: 4 articles (10/2019 - 01/2012)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2017 - "The ABCG2 protein has been a subject of intense study since its discovery as its overexpression has been detected in resistant cell lines in numerous types of human cancers. " 07/16/2020 - "Immunohistochemistry (IHC) analyses were performed on the primary tumor tissue in order to classify samples as high or low presence of ABCG2 protein. " 09/01/2018 - "The volume and mass of the subcutaneously implanted tumors in the ADM+Art high- and low-dose groups were significantly decreased than that in the control group (P < 0.05), while the apoptosis rate of tumor cells and the cellular concentration of ADM were increased significantly (P < 0.05), and the ABCG2 protein expression in the tumor cells decreased significantly (P < 0.05). " 12/01/2015 - "In pancreatic tissues with benign lesions, tissues with positive FRAT1 and ABCG2 protein expression exhibited dysplasia or intraepithelial neoplasia. " 12/01/2015 - "FRAT1 and ABCG2 protein was overexpressed in PDAC tumors compared to peritumoral tissues, benign pancreatic tissues, and normal pancreatic tissues (P < 0.01). "
2.	Colonic Neoplasms (Colon Cancer) 02/28/2021 - "In this study, we determined the efficacy of the novel benzamide derivative, VKNG-2, to overcome MDR due to the overexpression of the ABCG2 transporter in the colon cancer cell line, S1-M1-80. " 02/28/2021 - "The Novel Benzamide Derivative, VKNG-2, Restores the Efficacy of Chemotherapeutic Drugs in Colon Cancer Cell Lines by Inhibiting the ABCG2 Transporter." 02/28/2021 - "In contrast, in vitro, 5 μM of VKNG-2 did not significantly alter either the expression of ABCG2, AKT, and PI3K p110β protein or the subcellular localization of the ABCG2 protein compared to colon cancer cells incubated with the vehicle. " 11/27/2023 - "The studies showed that the previously described DMQCd, a penta-methoxylated N-carboranyl-2-phenylquinazolin-4-amine, was by far superior to its organic analogues in terms of cytotoxicity, inhibition of the human ABCG2 transporter, as well as the ability to reverse BCRP-mediated mitoxantrone resistance in MDCKII-hABCG2 and HT29 colon cancer cells. " 11/04/2020 - "Poziotinib Inhibits the Efflux Activity of the ABCB1 and ABCG2 Transporters and the Expression of the ABCG2 Transporter Protein in Multidrug Resistant Colon Cancer Cells."
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/2021 - "In this current study, we evaluated the efficacy of GS-9973 to overcome multidrug resistance (MDR) due to the overexpression of the ABCG2 transporter in the non-small cell lung cancer (NSCLC) cell line, NCI-H460/MX20. "
4.	Glioma (Gliomas) 05/28/2014 - "Downregulation of ABCG2 protein inhibits migration and invasion in U251 glioma stem cells." 01/01/2013 - "We aimed to investigate the role of the ABCG2 transporter in the efficacy of sonodynamic therapy (SDT) with Photofrin in the glioma stem-like cells (GSCs) isolated and cultured from U251 glioma cells. " 01/01/2013 - "The ABCG2 transporter is a key molecular determinant of the efficacy of sonodynamic therapy with Photofrin in glioma stem-like cells." 10/01/2009 - "Thus, inhibition of ABCG2 protein activity by nicardipine in glioma can sensitize it to mitoxantone, which may lead to better treatment strategies for cancers." 01/01/2022 - "Inhibition of ABCG2 transporter by lapatinib enhances 5-aminolevulinic acid-mediated protoporphyrin IX fluorescence and photodynamic therapy response in human glioma cell lines."
5.	Triple Negative Breast Neoplasms 10/01/2012 - "The presence of SP in FNAs were significantly associated with ER-negative (p=0.008) and with triple negative breast cancers (p=0.011) which were also found to have a significant increase in ABCG2 protein expression. " 08/18/2015 - "ABCG2 transporter inhibitor restores the sensitivity of triple negative breast cancer cells to aminolevulinic acid-mediated photodynamic therapy." 01/01/2023 - "Monoacylglycerol Lipase Inhibitor JJKK048 Ameliorates ABCG2 Transporter-Mediated Regorafenib Resistance Induced by Hypoxia in Triple Negative Breast Cancer Cells."

Related Drugs and Biologics

1.	Irinotecan (Camptosar)
2.	Mitoxantrone (Novantrone)
3.	MK 2206
4.	benzamide
5.	6- (1H- indazol- 6- yl)- N- (4- morpholinophenyl)imidazo(1,2- a)pyrazin- 8- amine
6.	Doxorubicin (Adriamycin)
7.	Topotecan (Hycamtin)
8.	Paclitaxel (Taxol)
9.	Dihematoporphyrin Ether (Porfimer Sodium)
10.	Monoacylglycerol Lipases

Related Therapies and Procedures

1.	Therapeutics
2.	Photochemotherapy (Photodynamic Therapy)
3.	Drug Therapy (Chemotherapy)
4.	Neoadjuvant Therapy
5.	Estrogen Replacement Therapy