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YH 439
structure given in first source
Also Known As:
YH-439; YH439; isopropyl 2-(1,3-dithioetane-2-ylidene)-2-(N-(4-methylthiazol-2-yl)carbamoyl)acetate
Networked:
9
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Sulfur Compounds: 278
Thiazoles: 392
YH 439: 9
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Thiazoles: 392
YH 439: 9
Related Diseases
1.
Necrosis
08/01/1998 - "
Administration of YH439 prevented centrilobular necrosis and significantly improved pharmacokinetic parameters.
"
2.
Carcinogenesis
04/01/1998 - "
Furthermore, pretreatment of female CD-1 mice with YH439 by gastric intubation resulted in diminution of VC-induced skin carcinogenesis.
"
01/25/1999 - "
In the present study, we found that oral administration of YH439 to CD-1 mice significantly suppressed B[a]P-initiated skin tumorigenesis.
"
01/25/1999 - "
Inhibitory effects of isopropyl-2-(1,3-dithietane-2-ylidene)-2- [N-(4-methylthiazol-2-yl)carbamoyl]acetate (YH439) on benzo[a]pyrene-induced skin carcinogenesis and micronucleated reticulocyte formation in mice.
"
3.
Body Weight (Weight, Body)
11/01/1998 - "
First-pass effects of YH439 were evaluated after intravenous, intraportal, oral, and intraduodenal administration of the drug, 100 mg/kg body weight, to rats.
"
02/01/1998 - "
Pharmacokinetic parameters of YH439 and its metabolites, M4, M5, and M7, were compared after iv administration of YH439 to rats (1-10 mg/kg), rabbits (1-10 mg/kg), and dogs (1-20 mg/kg) and oral administration of YH439 to rats (50-500 mg/kg) and dogs (0.5-2 g per whole body weight).
"
01/01/1996 - "
The metabolic changes of acetaminophen (AAP) were investigated after the intravenous (iv) administration of AAP, 300 mg per kg body weight, to the control rats (n = 7) and rats pretreated with a new hepatoprotective agent, YH-439 (200 mg per kg body weight, orally administered for 3 consecutive days, n = 7).
"
02/01/1996 - "
The effect of YH-439 pretreatment on the pharmacokinetics of furosemide and azosemide was investigated after intravenous (iv) administration of furosemide, 6 mg per whole body weight, and azosemide, 10 mg per kg body weight, to rats pretreated with 3 consecutive daily oral administration of YH-439, 200 mg per kg body weight.
"
4.
Liver Cirrhosis (Hepatic Cirrhosis)
04/06/1996 - "
Isopropyl-2-(1,3-dithietane-2-ylidene)-2[N-(4-methyl-2-thiazol+ ++-2-yl) carbamoyl]acetate (YH439) was synthesized as a hepatoprotective drug for the treatment of chronic hepatitis and liver cirrhosis.
"
5.
Hepatocellular Carcinoma (Hepatoma)
06/01/1996 - "
The dependency on the Ah receptor for the induction of CYP1A1/2 by YH439 was confirmed by the lack of CYP1A1/2 induction in the Ah receptor knock-out mice (Ahr-1-) as well as in murine hepatoma cells without a functional Ah receptor.
"
06/01/1996 - "
The molecular mechanism of induction of cytochromes P4501A1/2 (CYP1A1/2) by a synthetic compound YH439 was studied in rodents as well as in cultured hepatoma cells.
"
Related Drugs and Biologics
1.
Acetates (Acetic Acid Esters)
2.
Cytochrome P-450 CYP1A1 (CYP1A1)
3.
Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)
4.
Furosemide (Lasix)
5.
Cytochromes
6.
Benzo(a)pyrene
7.
Acetaminophen (Paracetamol)
8.
antiarrhythmic peptide (AAP)
9.
azosemide
Related Therapies and Procedures
1.
Oral Administration