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Benzo(a)pyrene

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A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.

Also Known As:

3,4-Benzpyrene; 3,4 Benzopyrene; 3,4 Benzpyrene; 3,4-Benzopyrene

Networked: 1245 relevant articles (22 outcomes, 156 trials/studies) for this Bio-Agent, Comments

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Bio-Agent Context: Research Results

Experts

1.	Spitz, Margaret R: 8 articles (01/2011 - 02/2002)
2.	Sinha, Rashmi: 6 articles (01/2012 - 09/2005)
3.	Wu, Xifeng: 5 articles (01/2011 - 04/2003)
4.	Wei, Qingyi: 5 articles (01/2011 - 02/2002)
5.	Ramakrishnan, G: 4 articles (11/2012 - 04/2008)
6.	Phillips, David H: 4 articles (11/2012 - 01/2008)
7.	Kamaraj, S: 4 articles (11/2012 - 04/2008)
8.	Jagan, S: 4 articles (11/2012 - 04/2008)
9.	Devaki, T: 4 articles (11/2012 - 04/2008)
10.	Arlt, Volker M: 4 articles (11/2012 - 01/2008)

Related Diseases

1.	Neoplasms (Cancer) 11/01/1975 - "Higher doses of benzo(a)pyrene were more effective in inducing lung, liver, and stomach tumors. " 03/01/2012 - "Further, in vivo pharmacodynamic studies were carried to check the therapeutic efficacy against benzo(a)pyrene [B(a)P]-induced stomach tumors in albino mice (Balb/C strain). " 12/01/2007 - "Those 2 isomers decreased the incidence of forestomach tumors induced by benzo (a) pyrene in mice. " 10/01/2007 - "Furthermore, CF-TP inhibited benzo[a]pyrene (B[a]P)/TPA-induced skin tumor formation and decreased the incidence of tumor. " 09/16/1997 - "Mechanism of differential efficacy of garlic organosulfides in preventing benzo(a)pyrene-induced cancer in mice." Order ALL the reference details at left...
2.	Lung Neoplasms (Lung Cancer) 04/01/2012 - "The aim of the present study is to divulge the chemopreventive and chemoprotective nature of ATRA during benzo(a)pyrene (B(a)P) induced lung cancer development in BALB/c mice. " 02/25/2006 - "The current experimental work deals with the immunomodulatory studies on the extract of Withania somnifera (L.) Dunal root powder against benzo(a)pyrene induced lung cancer in male Swiss albino mice. " 04/30/2004 - "In the present study, the level of benzo[a]pyrene 7,8-diol-9,10-epoxide-N(2)-deoxyguanosine (BPDE-N(2)-dG) in normal bronchial epithelial cells from non-cancerous bronchus of 22 lung cancer subjects was evaluated and compared to the lung parenchyma. " 12/03/1999 - "In the present study, the effect of a potent lung cancer carcinogen, benzo[a]pyrene (B[a]P) on p53 expression was investigated. " 08/01/1991 - "In the present quantitative risk assessment of indoor air pollution study, the result strongly shows an obvious on-site exposure-response relationship between benzo[a]pyrene concentration in indoor air and lung cancer mortality and strongly supports the hypothesis that indoor air pollution is the main risk factor in inducing lung cancer in Xuan Wei County. " Order ALL the reference details at left...
3.	Hepatocellular Carcinoma (Hepatoma) 01/01/1985 - "The present study describes a technique to permeabilize H-4-II-E rat hepatoma cells for the study of benzo(a)pyrene metabolism. " 05/01/2012 - "Oxidative stress and cell-cycle change induced by coexposed PCB126 and benzo(a) pyrene to human hepatoma (HepG2) cells." 12/24/2011 - "Mustard extracts displayed significant anti-genotoxicity against benzo(a)pyrene in human HepG2 hepatoma cells. " 11/28/2011 - "As a case study, the genotoxic carcinogen benzo[a]pyrene (B[a]P) and the human hepatoma cell line HepG2 were used to generate three comparable toxicogenomic data sets. " 01/01/2009 - "blazei against DNA damage induced by benzo[a]pyrene (B[a]P), using the comet assay (genotoxicity) and micronucleus assay with cytokinesis block (mutagenicity) in a human hepatoma cell line (HepG2). " Order ALL the reference details at left...
4.	Body Weight (Weight, Body) 08/01/1999 - "In an extended OECD 407 study protocol, including immune parameters, male Riv:Tox Wistar SPF rats were treated for 35 days with benzo[a]pyrene (B[a]p) (3, 10, 30, or 90 mg/kg body weight) by gavage. " 12/01/2011 - "Muta™Mouse were dosed daily for 28 days with benzo[a]pyrene (BaP; 0, 25, 50 and 75 mg/kg body weight/day) by oral gavage. " 06/01/2011 - "To investigate the effect of Ax on the metabolic activation of a typical promutagen, benzo[a]pyrene by CYP1A, we orally administrated Ax-containing oil (100 mg Ax/kg body weight/day for 3 days) to male Wistar rats. " 10/01/2008 - "Benzo[a]pyrene (B[a]P), a well-known mutagen, was given at a single dose of 100 mg/kg body weight intraperitoneally. " 08/01/2008 - "Groups II, III and IV were administered with benzo(a)pyrene (50 mg/kg body weight, orally) for 4 weeks (twice a week) to induced lung carcinogenesis. " Order ALL the reference details at left...
5.	Adenoma (Adenomas) 03/01/2010 - "Development of pulmonary adenomas was induced with benzo(a)pyrene. " 11/01/2005 - "Inhibition of benzo(a)pyrene induced lung adenoma by panax ginseng extract, EFLA400, in Swiss albino mice." 09/01/2005 - "We investigated meat, processed meat, HCAs, and the PAH benzo(a)pyrene and the risk of colorectal adenoma in 3,696 left-sided (descending and sigmoid colon and rectum) adenoma cases and 34,817 endoscopy-negative controls. " 08/01/2005 - "Dietary benzo[a]pyrene intake and risk of colorectal adenoma." 11/15/1996 - "In previous work, the two compounds were shown to inhibit benzo(a)pyrene [B(a)P]-induced pulmonary adenoma formation in female A/J mice when fed during the postinitiation period [ie., starting 1 week after the last of three administrations of B(a)P by oral intubation]. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	baicalein
2.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
3.	DNA Adducts
4.	Smoke
5.	Capsaicin (Zostrix)
6.	DNA (Deoxyribonucleic Acid)
7.	Carcinogens
8.	Paclitaxel (Taxol)
9.	Cytokines
10.	Enzymes

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Subcutaneous Injections
3.	Oral Administration
4.	Transplantation (Transplant Recipients)
5.	Thymectomy

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