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Aromatic Polycyclic Hydrocarbons (Polycyclic Aromatic Hydrocarbons)

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A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)

Also Known As:

Polycyclic Aromatic Hydrocarbons; Polynuclear Aromatic Hydrocarbons; Polycyclic Hydrocarbons, Aromatic; Aromatic Hydrocarbons, Polycyclic; Aromatic Hydrocarbons, Polynuclear; Hydrocarbons, Aromatic Polycyclic; Hydrocarbons, Polycyclic Aromatic; Hydrocarbons, Polynuclear Aromatic

Networked: 679 relevant articles (5 outcomes, 79 trials/studies) for this Bio-Agent, Comments

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hecht, Stephen S: 10 articles (09/2012 - 12/2002)
2.	Hochalter, J Bradley: 7 articles (09/2012 - 03/2009)
3.	Carmella, Steven G: 7 articles (09/2012 - 12/2003)
4.	Boffetta, Paolo: 7 articles (01/2012 - 09/2003)
5.	Teitelbaum, Susan L: 6 articles (04/2010 - 08/2002)
6.	Gammon, Marilie D: 6 articles (04/2010 - 08/2002)
7.	Santella, Regina M: 6 articles (04/2009 - 08/2002)
8.	Zhong, Yan: 5 articles (09/2012 - 01/2011)
9.	Upadhyaya, Pramod: 5 articles (09/2012 - 12/2002)
10.	Neugut, Alfred I: 5 articles (04/2010 - 08/2002)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2011 - "Although polycyclic aromatic hydrocarbons (PAHs) are carcinogenic and have been extensively studied with regard to tumor formation, few studies have investigated the involvement of these environmental chemicals in tumor migration and invasion. " 02/01/2005 - "Previous studies of lung tumors from both non-smoking women and smoking men in this region showed high frequencies of mutations, consisting mostly of G-->T transversions in the p53 tumor suppressor gene and K-ras oncogene, suggesting that these mutations were caused primarily by polycyclic aromatic hydrocarbons. " 01/01/2000 - "The long-range goal of the present study is the development of a general approach for in vivo dosimetry of reactive metabolites of polycyclic aromatic hydrocarbons (PAHs), to be used as a tool in cancer risk assessment. " 01/01/1984 - "Animal studies have linked aryl hydrocarbon hydroxylase (AHH) with cancer induction by polycyclic aromatic hydrocarbons (PAH), but the relationship between the activation of PAH by AHH and cancer induction in man is unclear. " 10/01/2012 - "Lifestyle habits such as smoking and alcohol consumption, exposure to certain chemicals (e.g., polycyclic aromatic hydrocarbons, organochlorines), metals and pesticides also pose risk in causing human cancers. " Order ALL the reference details at left...
2.	Stomach Neoplasms (Stomach Cancer) 01/01/1985 - "Frequent consumption of cured, pickled, or smoked foods, possibly because they may contain nitrosamines or polycyclic aromatic hydrocarbons, appears to increase the risk of esophageal or stomach cancer, however, the specific causative agents in these foods are not clearly identified. " 06/01/1983 - "In contrast, frequent consumption of salt-cured, salt-pickled, or smoked foods, possibly because they may contain nitrosamines or polycyclic aromatic hydrocarbons, appears to increase the risk of esophageal or stomach cancer. " Order ALL the reference details at left...
3.	Gilbert Disease 10/01/1992 - "Genetic deficiencies in bilirubin UDP-glucuronosyltransferase (GT) occur in >5% of the population (Gilbert's disease, Crigler-Najjar syndromes), and this could predispose such people to the toxic effects of polycyclic aromatic hydrocarbons and other environmental chemicals that are eliminated substantially by glucuronidation. " Order ALL the reference details at left...
4.	Lung Neoplasms (Lung Cancer) 07/01/2000 - "A mortality study on the association between lung cancer and occupational exposure to polycyclic aromatic hydrocarbons (PAHs) was carried out in a French aluminium reduction plant. " 11/01/1993 - "Exposure of pork butchers to polycyclic aromatic hydrocarbons during meat smoking, which was assessed in a contemporary study, might have contributed to their increased risk of lung cancer. " 02/01/2013 - "Pollution level, inhalation exposure and lung cancer risk of ambient atmospheric polycyclic aromatic hydrocarbons (PAHs) in Taiyuan, China." 06/01/2012 - "PM(10)-bound polycyclic aromatic hydrocarbons: biological indicators, lung cancer risk of realistic receptors and 'source-exposure-effect relationship' under different source scenarios." 03/01/2012 - "Dietary exposure estimates of 16 polycyclic aromatic hydrocarbons (PAHs) in Xuanwei and Fuyuan, counties in a high lung cancer incidence area in China." Order ALL the reference details at left...
5.	Breast Neoplasms (Breast Cancer) 04/01/2010 - "Previous studies have suggested that polycyclic aromatic hydrocarbons (PAHs) may be associated with breast cancer. " 10/01/1999 - "The objective of this study was to investigate whether polycyclic aromatic hydrocarbons (PAHs) contribute to the etiology of sporadic breast cancer by altering the expression of BRCA-1. " 07/01/2006 - "We previously developed a historical reconstruction model to estimate exposure to airborne polycyclic aromatic hydrocarbons (PAHs) from traffic back to 1960 for use in case-control studies of breast cancer risk. " 01/01/2005 - "Breast cancer risk and exposure in early life to polycyclic aromatic hydrocarbons using total suspended particulates as a proxy measure." 01/01/2002 - "Epigenetics of breast cancer: polycyclic aromatic hydrocarbons as risk factors." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Nitrosamines
2.	Epoxy Compounds (Epoxides)
3.	Protein Isoforms (Isoforms)
4.	Sterols
5.	bilirubin glucuronoside glucuronosyltransferase
6.	lathosterol
7.	Benzo(a)pyrene
8.	Carcinogens
9.	Amines
10.	Smoke

Related Therapies and Procedures

1.	Nuclear Power Plants
2.	Electrodes (Electrode)

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