nimbolide

12/01/2019 - "Histopathological findings showed significant reduction in destruction of joints and inflammation following nimbolide treatment. "
06/01/2022 - "Based on the findings, we may conclude that nimbolide protects the pregnant rats from GDM via alteration of inflammation, oxidative stress, and gut microbiota."
01/01/2022 - "We observed for the first time about nimbolide can effectively inhibit inflammation in AIH mice's liver and AML12 cells by inhibiting HDAC3 expression. "
01/01/2022 - "Nimbolide attenuated the inflammation in the liver of autoimmune hepatitis's mice through regulation of HDAC3."
02/01/2019 - "Nimbolide also profoundly caused the regression of established inflammation-driven fibrosis, thus demonstrating both antifibrotic and anti-inflammatory activities. "

01/01/2022 - "In the present review, we summarized all the in vitro and in vivo studies reporting the molecular targets of nimbolide for the therapeutic approaches in different types of cancer cells. "
04/01/2021 - "So far, no study has been conducted to observe the effect of nimbolide on cancer cell metabolism. "
12/07/2020 - "Our current study showed for the first time that nimbolide exhibits anticancer effect by reducing tumor size, tumor burden and by suppressing cell cycle progression in HCC mice. "
01/01/2019 - "The present study was designed to investigate the in-vitro morphological assessment of apoptotic effect caused by nimbolide on the selected cancer cell lines (DU-145, PC-3, A-549) and normal cell lines (NIH3T3, CCD-18Co). "
09/01/2018 - "An in vivo study showed that nimbolide significantly reduced Huh-7 tumor growth and weight in a xenograft mouse model. "

01/25/2016 - "This study assessed the anticancer properties of nimbolide against pancreatic cancer. "
03/01/2022 - "Nimbolide-encapsulated PLGA nanoparticles induces Mesenchymal-to-Epithelial Transition by dual inhibition of AKT and mTOR in pancreatic cancer stem cells."
01/01/2018 - "Nimbolide reduces CD44 positive cell population and induces mitochondrial apoptosis in pancreatic cancer cells."
01/25/2016 - "Overall, our data suggest that nimbolide can serve as a potential chemo-therapeutic agent for pancreatic cancer. "
01/25/2016 - "In vivo experiments also demonstrated that nimbolide was effective in inhibiting pancreatic cancer growth and metastasis. "

10/01/2019 - "Our study demonstrates Nimbolide as a potent anti-fibrotic agent and its ability to regulate fibrosis associated autophagy."
01/01/2019 - "Nimbolide ameliorates unilateral ureteral obstruction-induced renal fibrosis by inhibition of TGF-β and EMT/Slug signalling."
02/01/2019 - "Nimbolide also profoundly caused the regression of established inflammation-driven fibrosis, thus demonstrating both antifibrotic and anti-inflammatory activities. "
02/01/2019 - "Nimbolide ameliorates fibrosis and inflammation in experimental murine model of bleomycin-induced scleroderma."
10/01/2019 - "The present study investigated the role of Nimbolide, an important active constituent of Neem in TGF-β1 induced in vitro and bleomycin induced in vivo model of pulmonary fibrosis, with a slight emphasis on regulation of fibrosis related autophagy. "

12/01/2022 - "The body weight of GCs group rats considerably suppressed and nimbolide treatment remarkably improved the body weight. "
01/01/2022 - "Nimbolide treated groups significantly (p < 0.001) suppressed the body weight at dose dependent manner. "
12/01/2019 - "Rats treated with nimbolide displayed marked reduction in arthritic score, organ indices, volume of paw, edema formation, along with substantial enhancement in body weight. "
03/01/2023 - "Rats treated with nimbolide showed a significant reduction in inflammatory cells, rheumatoid factor, ESR, and improved the body weight. "
06/01/2022 - "Nimbolide treatment significantly (p < .001) suppressed the BGL and enhanced the body weight, insulin level. "