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Streptozocin (Streptozotocin)

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An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.

Also Known As:

Streptozotocin; Zanosar; 2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose; Streptozotocine; Teva Brand of Streptozocin; Streptozocin Teva Brand; D-Glucose, 2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-

Networked: 5149 relevant articles (212 outcomes, 768 trials/studies) for this Drug, Comments

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Drug Context: Research Results

Experts

1.	Chopra, Kanwaljit: 9 articles (06/2011 - 04/2004)
2.	Singh, Nirmal: 8 articles (05/2012 - 03/2008)
3.	Pari, Leelavinothan: 7 articles (09/2012 - 01/2004)
4.	Zhang, Li: 7 articles (02/2012 - 01/2006)
5.	Schultheiss, Heinz-Peter: 7 articles (06/2009 - 07/2003)
6.	Nath, Chandishwar: 6 articles (01/2012 - 03/2008)
7.	Kelly, Darren J: 6 articles (01/2012 - 06/2002)
8.	McNeill, John H: 6 articles (10/2009 - 12/2004)
9.	Tschöpe, Carsten: 6 articles (06/2009 - 07/2003)
10.	Yokozawa, Takako: 6 articles (04/2009 - 01/2004)

Related Diseases

1.	Hyperglycemia 11/01/2012 - "sumatrana aqueous extract is beneficial for improvement of hyperglycemia by increasing gene expression of liver Slc2a2 and reducing expression of G6Pase and PCK1 genes in streptozotocin-induced diabetic rats." 09/01/1987 - "Of 22 immunomodulatory substances screened 12 were effective in modulating the course of hyperglycemia following low dose streptozotocin treatment. " 06/01/2010 - "In this study, we investigated the protective effects of fermented ginseng (FG) on hyperglycemia induced by streptozotocin (STZ) in Sprague Dawley rats. " 03/01/2012 - "Cyanidin-3-glucoside-rich extract from Chinese bayberry fruit protects pancreatic β cells and ameliorates hyperglycemia in streptozotocin-induced diabetic mice." 10/01/2009 - "Eucalyptus probably restores antioxidant power, due to the improved hyperglycemia in streptozotocin-induced diabetic rats." Order ALL the reference details at left...
2.	Diabetic Nephropathies (Diabetic Nephropathy) 06/01/2010 - "This study investigates whether prolonged administration of PTX (40 mg/kg, per oral) is effective in streptozotocin-induced diabetic nephropathy. " 01/01/2009 - "Gallotannin ameliorates the development of streptozotocin-induced diabetic nephropathy by preventing the activation of PARP." 09/01/2012 - "This study investigated the effects of sEH gene disruption on diabetic nephropathy in streptozotocin-induced diabetic mice. " 07/01/2012 - "The present study was undertaken to investigate the effect of Asparagus racemosus Willd (Liliaceae) on streptozotocin-induced early diabetic nephropathy. " 07/01/2012 - "The present study was undertaken to characterize the effects of Corni Fructus on diabetic nephropathy in streptozotocin-induced diabetic rats and their mechanisms. " Order ALL the reference details at left...
3.	Diabetes Mellitus 02/01/2008 - "Protective effects of an herbal formulation of Radix Astragali, Radix Codonopsis and Cortex Lycii on streptozotocin-induced apoptosis in pancreatic beta-cells: an implication for its treatment of diabetes mellitus." 01/01/2012 - "To provide insights into the molecular mechanisms underlying diabetes mellitus, we performed a proteomic study on two diabetic animal models, streptozotocin (STZ)-induced diabetic rats (T1DM) and genetically diabetic (C57BL/6J ob/ob) mice (T2DM). " 12/01/2011 - "In order to study if advanced glycation endproducts (AGE) in high-temperature cooked high fat diet could be the cause of type 2 diabetes, a expressing vector encoding soluble form of receptor for AGE (sRAGE) was injected intramuscularly, and the incidence of streptozotocin (STZ)-induced diabetes mellitus in rats on high fat diet were observed. " 08/01/2011 - "This study seeks to characterize corneal functions and complications in a streptozocin (STZ)-induced rat model of type I diabetes mellitus (DM) and to understand the pathogenesis of diabetic keratopathy. " 08/01/2011 - "The experimental study part consisted of 24 Sprague--Dawley rats with streptozotocin-induced diabetes mellitus and 24 age-matched control animals without diabetes. " Order ALL the reference details at left...
4.	Body Weight (Weight, Body) 01/01/2010 - "In the present study, we aimed at verifying whether such modulatory effects of PAMAM G4 (0.5 micromol/kg of body weight daily for 60 days) may contribute to improved respiration in heart and liver mitochondria from streptozotocin-diabetic rats. " 10/01/2012 - "The present study evaluated the antihyperglycaemic effect of its aqueous extract administered orally (daily) in three different doses (100, 300, 500 mg/kg body weight) for a period of 30 d to streptozotocin (STZ)-induced diabetic rats. " 07/01/2012 - "In the present study, the antioxidative potential of Trigonella foenum-graecum seed powder was assessed in high fat diet and low dose streptozotocin (35 mg/kg body weight) induced type II diabetic rats. " 04/01/2003 - "Thus, by the administration of different doses of streptozotocin (STZ) (0, 25, 30, or 35 mg/kg body weight, intravenous) at the onset of pregnancy in rats, the present study sought an appropriate animal model for this pathology. " 01/01/2002 - "These were obtained from 22 Syrian hamsters injected with streptozotocin (50 mg/kg body weight., intraperitoneal route) 90 days before the study began. " Order ALL the reference details at left...
5.	Hyperalgesia 03/06/2007 - "Eight weeks streptozotocin-diabetic rats developed neuropathy which was evident from significant reduction in motor nerve conduction velocity (MNCV), nerve blood flow (NBF) and increased thermal hyperalgesia. " 05/01/2011 - "Hence, the present study was designed as a 24-week longitudinal investigation of the extent to which the level of glycemic control in the streptozotocin (STZ)-diabetic rat model of Type 1 diabetes affects the development of mechanical allodynia and opioid hyposensitivity in these animals. " 03/01/2008 - "In the present study, using streptozotocin (STZ)-induced diabetic rats that displayed tactile allodynia, we found several morphological changes of activated microglia in the dorsal horn. " 11/01/2004 - "The present study was aimed at evaluating the role of PDE-5 inhibitor on nociception in streptozotocin-induced diabetes in animal models of nociception (writhing assay in mice and paw hyperalgesia test in rats). " 08/01/2003 - "Recent studies from our laboratory demonstrated that BKB1-R are implicated in streptozotocin (STZ)-diabetes-mediated hyperalgesia, since acute administration of the selective BKB1-R antagonists significantly and dose-dependently inhibited such hyperalgesic activity. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Glucose (Dextrose)
3.	Doxorubicin (Adriamycin)
4.	Fluorouracil (Carac)
5.	Blood Glucose (Blood Sugar)
6.	Niacinamide (Nicotinamide)
7.	Melatonin
8.	Aldehyde Reductase (Aldose Reductase)
9.	Taurine
10.	Lipoproteins (Lipoprotein)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Oral Administration
3.	Transplantation (Transplant Recipients)
4.	Intravenous Injections
5.	Isogeneic Transplantation

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