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Type 1 Diabetes Mellitus (Autoimmune Diabetes)

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A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.

Also Known As:

Autoimmune Diabetes; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Autoimmune Diabete; Brittle Diabetes Mellitus; Diabete, Autoimmune; Diabetes Mellitus, Insulin Dependent; Diabetes Mellitus, Juvenile Onset; Diabetes Mellitus, Ketosis Prone; Diabetes Mellitus, Sudden Onset; Insulin-Dependent Diabetes Mellitus; Juvenile-Onset Diabetes Mellitus; Ketosis-Prone Diabetes Mellitus; Mellitus, Sudden-Onset Diabetes; Sudden-Onset Diabetes Mellitus; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes, Autoimmune; IDDM

Networked: 10130 relevant articles (413 outcomes, 1487 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Type 1 Diabetes Mellitus (Autoimmune Diabetes)
2.	Type 2 Diabetes Mellitus (MODY)
3.	Hypoglycemia (Reactive Hypoglycemia)
4.	Diabetes Mellitus
5.	Hyperglycemia

Experts

1.	Sanjeevi, C B: 20 articles (04/2007 - 08/2001)
2.	Shtauvere-Brameus, A: 14 articles (04/2002 - 04/2002)
3.	Huang, Gan: 11 articles (10/2012 - 11/2003)
4.	Eisenbarth, George S: 11 articles (10/2012 - 04/2002)
5.	Bluestone, Jeffrey A: 10 articles (09/2012 - 10/2002)
6.	Myśliwska, Jolanta: 9 articles (10/2012 - 06/2005)
7.	Myśliwiec, Małgorzata: 9 articles (10/2012 - 01/2002)
8.	Li, Xia: 9 articles (10/2012 - 11/2003)
9.	Tamborlane, William V: 9 articles (09/2012 - 04/2003)
10.	Pozzilli, P: 9 articles (04/2012 - 08/2001)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Type 1 Diabetes Mellitus:

1.	Insulin (Novolin)FDA Link 08/01/1990 - "Therefore, most studies have failed to demonstrate improved glycemic control after adding sulfonylurea to insulin therapy in patients with insulin-dependent diabetes mellitus. " 10/01/1993 - "Moreover, after the clinical onset of IDDM, most patients experience a transitory period of improved insulin secretion. " 07/01/2002 - "Diabetic patients undergo an important oxidative stress that is nearly corrected for IDDM, but only partially improved for ITDM2, although length of insulin treatment and HbA1c values are similar, suggesting metabolic differences between the two types of diabetes." 12/01/1991 - "Insulin replacement is the mainstay of treatment in IDDM; however, optimal therapy requires a careful balance of food, insulin, and physical activity. " 04/01/2006 - "The honeymoon period (i.e., partial remission) of type 1 diabetes mellitus is characterized by reduced insulin requirements while good glycemic control is maintained. " Order ALL the reference details at left...
2.	Glucose (Dextrose)FDA LinkGeneric 03/01/1998 - "Significantly greater concentrations of glucose were seen in saliva and serum in children with IDDM. " 07/01/1984 - "Normalization of glucose tolerance by means of GCIIS was associated with significant improvement of lipid metabolism in IDDM. " 08/01/2011 - "The aim of this study was to evaluate the efficacy of short-term continuous glucose monitoring system (CGMS) application in improvement of glycemic control in pediatric type 1 diabetes mellitus (T1DM) patients. " 06/01/1997 - "The Glucose Evaluation Trial for Remission (GETREM): A European effort to evaluate insulin-dependent diabetes mellitus in the first year after diagnosis." 08/01/1984 - "Thus, the efficacy of the glucose counterregulatory systems determines the limits of intensive therapy of IDDM." Order ALL the reference details at left...
3.	Blood Glucose (Blood Sugar)IBA 03/01/1989 - "Our data suggest that clinic-based problem-solving groups can be more effective with young adolescents with IDDM than conventional treatment in preventing the expected deterioration in blood glucose." 08/01/1998 - "In the present study, we have examined the effect of an improved blood glucose control on plasma levels of hydroperoxides in patients with IDDM. " 06/01/1997 - "In patients with IDDM our studies demonstrated the limitations of traditional clinical judgement and the laboratory procedures in providing an accurate assessment of blood glucose control and that knowledge of HbA1c values allowed the clinician to identify patients in poor glycemic control and lead to improvement in glycemic control. " 09/01/1996 - "Microangiopathy is retarded by improved blood glucose control in patients with IDDM. " 08/01/1989 - "Improved blood glucose control, without 'near normoglycaemia', delayed the progression of nephropathy in patients with IDDM and retinopathy." Order ALL the reference details at left...
4.	C-PeptideIBA 07/01/1998 - "To investigate the role of puberty on spontaneous clinical remission and on secretion of residual C-peptide during the first year of type 1 diabetes mellitus, we studied 77 pre-pubertal, 39 pubertal and 41 post-pubertal type 1 diabetic patients. " 01/01/1998 - "In addition, replacement of C-peptide during a period of 1-3 months has been shown to improve renal function as well as autonomic and sensory nerve function in IDDM patients. " 01/01/2007 - "At present, in view of numerous studies concerning its structure, membrane binding and biological functions, C-peptide seems to constitute a crucial role in the pathogenesis of complications in diabetes mellitus type 1 (DM1). " 04/01/2005 - "Recent studies have demonstrated that replacement of C-peptide to normal physiological concentrations in IDDM patients either on a short-term basis (1-3 hours) or on a prolonged administration (1-3 months) was accompanied by improvements in renal glomerular and tubular function. " 05/01/2004 - "The study included 20 participants with C-peptide-deficient Type 1 diabetes mellitus. " Order ALL the reference details at left...
5.	Cyclosporine (Ciclosporin)FDA LinkGeneric 09/01/1992 - "Several studies have demonstrated the efficacy of cyclosporin A in modifying the initial course of Type 1 (insulin-dependent) diabetes mellitus in older children and adults but none have reported the effects in very young children. " 09/01/1987 - "We have developed a protocol of prophylactic cyclosporin A administration which confers complete and permanent protection against insulin-dependent diabetes mellitus in diabetes-prone BioBreeding rats. " 09/01/2010 - "Administration of high-dose cyclosporin (cyclo) has been demonstrated to induce remission of type 1 diabetes mellitus (T1D). " 09/01/1987 - "Cyclosporin A prophylaxis initiated later, but still before the onset of clinical symptoms (8-9 weeks), and terminated at 22-23 weeks, was only partially effective; 5/20 (25%) of cyclosporin A-treated rats developed insulin-dependent diabetes mellitus, compared to 60% (12/20) of controls (p less than 0.05). " 04/01/1988 - "The subjects were drawn from a pilot study (The Canadian Open Study on the effects of immunosuppression with Cyclosporine in Type 1 Diabetes Mellitus) in which 50% of the patients demonstrated remission during one year of cyclosporine administration. " Order ALL the reference details at left...
6.	AntibodiesIBA 09/01/1996 - "Thus, p277 peptide therapy, marked by the induction of Th2-type antibodies, can be effective in toxin-induced autoimmune diabetes." 02/01/2006 - "Measurement of antigliadin antibodies in patients with diabetes mellitus type 1 helped in the selection of patients to undergo jejunal biopsy. " 02/01/2003 - "In mouse models of autoimmune diabetes, CD3-specific antibodies induce stable disease remission by restoring tolerance to pancreatic beta-cells. " 08/01/1996 - "Although the positivity was low, the detection of hsp60 antibodies may be helpful for diagnosis of IDDM especially in GAD65 Ab- or JCA-negative Japanese patients." 04/01/1980 - "Pancreatic islet-cell antibodies (I.C.Ab.) were detected in the sera of 6 of 123 patients with insulin-dependent diabetes mellitus of recent onset, compared with only 2 positive results among the 434 control sera. " Order ALL the reference details at left...
7.	insulin LISPRO (Humalog)FDA Link 05/01/1999 - "Long-term efficacy of humalog in subjects with Type 1 diabetes mellitus." 08/01/1997 - "Strategies toward improved control during insulin lispro therapy in IDDM. " 03/01/1997 - "Prolonged efficacy of short acting insulin Lispro in combination with human ultralente in insulin-dependent diabetes mellitus." 09/01/2008 - "We simulate pulsatile implementations of a basal rate profile over a day on a type 1 diabetes mellitus patient using insulin lispro. " 01/01/2003 - "Pregnancy outcome in Type 1 diabetes mellitus treated with insulin lispro (Humalog)." Order ALL the reference details at left...
8.	Lipoproteins (Lipoprotein)IBA 12/01/1998 - "The comparison of examined groups showed statistically significant higher susceptibility on the oxidation of chosen lipoproteins in pregnant with IDDM. " 07/01/1991 - "Abnormal clearance of postprandial Sf 100-400 plasma lipoproteins in insulin-dependent diabetes mellitus." 12/01/2001 - "In conclusion, children with type 1 diabetes mellitus included in this study did not have high-risk lipoprotein profiles at this early stage of life. " 12/01/1998 - "The aim of study was estimation of susceptibility on the process of oxidation of selected lipoproteins of pregnant women with IDDM in II, III trimester of pregnancy. " 05/01/1998 - "This study suggests that moderate alcohol consumption has no beneficial effect on the lipoprotein profile in IDDM men. " Order ALL the reference details at left...
9.	Niacinamide (Nicotinamide)FDA LinkGeneric 06/01/1998 - "The first of these trials, The Deutsche Nicotinamide Intervention Study (DENIS), evaluated the clinical efficacy of high doses of nicotinamide in children at high risk for IDDM. " 03/01/2009 - "It is suggested that nicotinamide might be considered an effective agent for the prevention and treatment of IDDM in prediabetic, and early stages, of IDDM." 01/01/1992 - "To determine the efficacy of nicotinamide in inducing remission in early-onset insulin-dependent diabetes mellitus. " 03/01/2009 - "This study was conducted to investigate the effect of nicotinamide on experimentally-induced IDDM. " 01/01/2001 - "Update on major trials for the prevention of type 1 diabetes mellitus: the American Diabetes Prevention Trial (DPT-1) and the European Nicotinamide Diabetes Intervention Trial (ENDIT)." Order ALL the reference details at left...
10.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 10/01/1992 - "Studies have demonstrated that "antihypertensive" treatment with angiotensin-converting enzyme inhibitors (ACEI) may retard the progress of nephropathy in patients with insulin-dependent diabetes mellitus. " 01/01/2004 - "Current guidelines recommend treating patients with type 1 diabetes mellitus with ACE inhibitors after the onset of microalbuminuria. " 11/01/2002 - "The ACE inhibitors are still the drug of choice for patients with type 1 diabetes mellitus and evidence of incipient or overt nephropathy. " 03/06/2001 - "In normotensive patients with type 1 diabetes mellitus and microalbuminuria, ACE inhibitors significantly reduced progression to macroalbuminuria and increased chances of regression. " 03/06/2001 - "Should all patients with type 1 diabetes mellitus and microalbuminuria receive angiotensin-converting enzyme inhibitors? " Order ALL the reference details at left...

Therapies and Procedures

1.	Transplantation (Transplant Recipients) 01/01/2012 - "Parenteral administration of anti-CD3 monoclonal antibody is an approved therapy for transplantation in humans and is effective in autoimmune diabetes. " 06/01/2009 - "Pancreatic islet transplantation is a promising therapeutic treatment for type 1 diabetes mellitus. " 01/01/2009 - "Pancreatic islet transplantation has the potential to be an effective treatment for type 1 diabetes mellitus. " 11/15/2008 - "Parenteral administration of anti-CD3 monoclonal antibody is an approved therapy for transplantation in humans and is effective in autoimmune diabetes. " 03/01/2007 - "Simultaneous pancreas-kidney (SPK) transplantation is an effective treatment for patients suffering from type 1 diabetes mellitus. " Order ALL the reference details at left...
2.	Islets of Langerhans Transplantation 08/01/2005 - "Improved human pancreatic islet isolation for a prospective cohort study of islet transplantation vs best medical therapy in type 1 diabetes mellitus." 03/27/1999 - "The findings have potential implications for islet transplantation as well as improved and more cost-effective therapy for IDDM." 01/01/2009 - "Islet transplantation has recently emerged as an effective therapy and potential cure for type 1 diabetes mellitus. " 02/01/2008 - "We conclude that in islet transplantation and autoimmune diabetes, ICOS blockade can be effective in inhibiting alloimmunity and preventing autoimmunity but is ineffective in inhibiting recurrence of autoimmunity." 04/27/1994 - "Islet transplantation can provide a therapeutic option for patients who suffer from type 1 diabetes mellitus, especially if current aggressive immunosuppression could be eliminated. " Order ALL the reference details at left...
3.	Kidney Transplantation 12/01/1994 - "PKT has become an important option in selected IDDM patients being considered for kidney transplantation because of its ability to offer superior glycemic control and improved quality of life. " 05/01/2005 - "Simultaneous pancreas-kidney transplantation (SPK) has evolved as an effective treatment for patients with end-stage nephropathy due to type 1 diabetes mellitus. " 06/21/2002 - "The pancreas kidney transplantation (PKTx) currently is the only treatment for cure for patients with diabetes mellitus Type 1. Despite the availability of organs and the need for therapy the PKTx rate is much lower in Germany than it is in the United States. " 10/01/2009 - "The aim of the study was to compare the quality of life (QOL) of patients with IDDM and CRF subjected to SPK or kidney transplantation alone (KTA). " 03/01/2010 - "Its most prevalent indication is in association with kidney transplantation (simultaneous pancreas and kidney transplantation SPK) for patients with type 1 diabetes mellitus (DM1) and nephropathy, who are under dialysis treatment. " Order ALL the reference details at left...
4.	Injections 04/01/2009 - "The aim of the present study was to compare the efficacy of MDI (three or more injections daily) with CSII on glycemic control in patients with Type 1 Diabetes Mellitus and assess satisfaction from treatment in the CSII group. " 09/01/1997 - "In a more recent crossover study (1996), 199 well-controlled IDDM patients (HbA1C = 7.3%) were treated intensively by multiple injections. " 03/01/1997 - "Prospective measurements of standing height and weight were recorded longitudinally in 634 children after IDDM onset (median age at onset, 9 years [range 1-15 years]; median diabetes duration at final examination, 11 years [range 1-19]; 3,236 patient-years on two or three injections daily; 399 patient-years on multiple injection therapy [MIT]). " 09/16/1995 - "We assessed the incidence of nocturnal hypoglycaemia and the benefit of an additional bedtime snack in IDDM patients treated by 2 or 3 daily injections. " 07/01/1994 - "Insuflon can be offered as an alternative to patients with IDDM who find regular injections uncomfortable." Order ALL the reference details at left...
5.	Pancreas Transplantation 04/01/2008 - "Pancreas transplantation is currently considered to be the most reliable and effective treatment for insulin-dependent diabetes mellitus (also called type 1 diabetes). " 12/01/2010 - "Simultaneous kidney and pancreas transplantation (SKPT) has become an effective treatment for patients who have diabetes mellitus type I with advanced nephropathy. " 03/01/1997 - "To determine the safety and efficacy of solitary pancreas transplantation in the treatment of IDDM. " 09/01/2003 - "Solitary pancreas or combined kidney-pancreas transplantation is currently the only therapeutic procedure for complete resolution of diabetes mellitus type I. The aim of the present study is to investigate the role of multislice computed tomography (MSCT) in the follow-up of patients subjected to solitary pancreas or combined kidney-pancreas transplantation. " 10/01/2000 - "The purpose of this study was to find out whether prolonged normoglycemia, as achieved by a successful pancreas transplantation, can improve survival in patients with insulin-dependent diabetes mellitus. " Order ALL the reference details at left...

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