mogrol

01/01/2015 - "Mogrol, a biometabolite of mogrosides found in Siraitia grosvenorii, has exhibited anti-cancer activities; however, the underlying mechanism of this effect remains unclear. "
01/01/2022 - "In this study, we observed that mogrol exposure significantly reduced the tumor volume and weight in tumor-bearing nude mice without obvious effect on body weight and cardiac function. "
01/01/2015 - "To clarify its anti-cancer activity and mechanism of action, we treated K562 leukemia cells with mogrol. "

01/01/2022 - "Our results indicated that mogrol effectively suppressed lung cancer cells in vivo and in vitro by inducing the excessive autophagy and autophagic cell death via activating AMPK signaling pathway, as well as cell cycle arrest and apoptosis via activating p53 pathway."
01/01/2022 - "In addition, mogrol induced a significant increase in p53 activity in lung cancer cells, accompanied with cell cycle arrest and apoptosis, which could be weakened by p53 silence. "
01/01/2022 - "However, little is known about the pharmacological mechanisms underlying the suppression of mogrol on lung cancers. "
01/01/2022 - "Mogrol suppresses lung cancer cell growth by activating AMPK-dependent autophagic death and inducing p53-dependent cell cycle arrest and apoptosis."
01/01/2021 - "The research stimulated the development of potential therapeutic agent for lung cancer from the natural mogrol."

05/01/2019 - "This study suggested that mogrol would ameliorate the memory impairment induced by Aβ1-42 , which is involved in anti-inflammation and anti-apoptosis in the brain."

01/01/2022 - "In this study, we observed that mogrol exposure significantly reduced the tumor volume and weight in tumor-bearing nude mice without obvious effect on body weight and cardiac function. "

01/01/2022 - "In conclusion, these data showed that mogrol may be a promising procedure for osteoporosis prevention or therapy."
01/01/2022 - "Mogrol Attenuates Osteoclast Formation and Bone Resorption by Inhibiting the TRAF6/MAPK/NF-κB Signaling Pathway In vitro and Protects Against Osteoporosis in Postmenopausal Mice."