anti-transglutaminase autoantibody

Also Known As:

Anti-TGM antibody; Anti-tissue transglutaminase antibody; Anti-transglutaminase 2 autoantibody; Anti-transglutaminase 6 autoantibody; Anti-transglutaminase autoantibodies; IgA anti-tTG; IgA anti-tissue transglutaminase autoantibodies; IgG anti-tTG; IgG anti-tissue transglutaminase autoantibodies; TGM6 autoantibody; anti-TGM6 autoantibody; anti-endomysial tissue transglutaminase 2 autoantibody; anti-tTG2 autoantibody; transglutaminase 6 autoantibody

Networked: 91 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Autoantibodies: 35785
        anti-transglutaminase autoantibody: 91
    - Immunoproteins: 43
      - Immunoglobulins: 30480
        Antibodies: 133716
        Autoantibodies: 35785
        anti-transglutaminase autoantibody: 91
  - Globulins: 3062
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Autoantibodies: 35785
        anti-transglutaminase autoantibody: 91

Experts

1.	Villalta, Danilo: 7 articles (01/2012 - 07/2002)
2.	Makharia, Govind K: 6 articles (12/2021 - 03/2014)
3.	Tonutti, Elio: 6 articles (01/2012 - 07/2002)
4.	Bizzaro, Nicola: 5 articles (01/2012 - 07/2002)
5.	Verma, Anil K: 4 articles (12/2021 - 03/2014)
6.	Schuppan, Detlef: 4 articles (12/2018 - 01/2006)
7.	Bossuyt, Xavier: 4 articles (04/2013 - 01/2010)
8.	Vermeersch, Pieter: 4 articles (04/2013 - 01/2010)
9.	Tozzoli, Renato: 4 articles (01/2012 - 07/2002)
10.	Ahuja, Vineet: 3 articles (12/2021 - 01/2016)

Related Diseases

1.	Celiac Disease (Celiac Sprue) 07/01/2019 - "This study aimed to evaluate a possible association between the anti-tissue transglutaminase antibody (anti-tTG) titer and stage of duodenal mucosal damage and assess a possible cut-off value of anti-tTG at which celiac disease (CD) may be diagnosed in children in conjunction with clinical judgment. " 02/01/2023 - "[Association between anti-tissue transglutaminase antibody titers and duodenal histopathology among adults with celiac disease]." 03/03/2021 - "Association of Anti-tissue Transglutaminase Antibody Titers and Duodenal Biopsy Findings in Pediatric Patients of Celiac Disease." 01/01/2017 - "Anti-transglutaminase autoantibodies (TGA) for celiac disease were also measured. " 03/01/2016 - "First-degree relatives were screened prospectively for celiac disease using questionnaire-based interview and anti-tissue transglutaminase antibody. "
2.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 05/01/2012 - "Spontaneous normalization of anti-tissue transglutaminase antibody levels is common in children with type 1 diabetes mellitus." 05/01/2012 - "Prevalence of celiac disease in children with type 1 diabetes mellitus screened by anti-tissue transglutaminase antibody from Western Saudi Arabia." 10/01/2012 - "IgA anti-transglutaminase autoantibodies at type 1 diabetes onset are less frequent in adult patients and are associated with a general celiac-specific lower immune response in comparison with nondiabetic celiac patients at diagnosis." 01/01/2019 - "Role of HLA-DQ typing and anti-tissue transglutaminase antibody titers in diagnosing celiac disease without duodenal biopsy in type 1 diabetes: A study of the population-based pediatric type 1 diabetes cohort of Western Australia." 12/01/2018 - "Between 10 and 30% of patients with celiac disease are thyroid and/or type 1 diabetes antibody positive, while around 5 to 7% of patients with autoimmune thyroid disease and/or type 1 diabetes are IgA anti-tissue transglutaminase antibody positive. "
3.	Liver Diseases (Liver Disease) 08/01/2007 - "Since it is not known whether various available methods for measuring IgG anti-tTG antibodies offer similar diagnostic performances, we have compared the results obtained from nine second-generation commercial methods (D-tek, Phadia, Immco, Orgentec, Radim, Euroimmun, Inova, Aesku, Generic Assays), measuring IgG anti-tTG antibodies in 20 patients with CD and SIgAD and in 113 controls (9 patients with SIgAD without CD, 54 patients with chronic liver disease, and 50 healthy individuals). " 03/01/2012 - "Serological screening with IgA anti-tTG antibody test should be routinely performed in patients presenting with abnormal LFT and especially those with chronic liver diseases including hypertransaminasemia, autoimmune hepatitis, and cryptogenic cirrhosis." 11/21/2012 - "We found that 29 of 962 patients (3%) with liver diseases and 5 of 523 patients (0.8%) who underwent OLTx were seropositive for IgA and IgG anti-tTG antibodies. " 01/01/2006 - "New studies are necessary to clarify if this increased risk is due to undiagnosed celiac disease or/and if this elevated IgA anti-tTG antibodies level is a marker of serious diseases like cancer, chronic liver disease or end-stage heart failure." 07/01/2007 - "20 CD patients with SIgAD and 113 controls (9 patients with SIgAD without CD; 54 patients with chronic liver disease; 50 healthy subjects) were tested with 9 IgG anti-tTG assays (2 of which are enriched with gliadin peptides), one IgG AGA assay and one IgG anti-DGP assay. "
4.	Neoplasms (Cancer) 01/01/2006 - "Individuals with elevated IgA anti-tTG antibodies had a highly increased mortality risk, particularly due to cancer. " 01/01/2006 - "New studies are necessary to clarify if this increased risk is due to undiagnosed celiac disease or/and if this elevated IgA anti-tTG antibodies level is a marker of serious diseases like cancer, chronic liver disease or end-stage heart failure."
5.	Joint Diseases (Joint Disease) 10/01/2002 - "A good correlation between serum and synovial fluid anti-tTG levels was found in all arthropathies This study suggests that tTG is not the only antigen of EMA and, furthermore, that IgA anti-tTG antibodies represent a general lesion-associated event. "

Related Drugs and Biologics

1.	Gliadin
2.	Peptides (Polypeptides)
3.	Antibodies
4.	Immunoglobulin G (IgG)
5.	Antigens
6.	Rheumatoid Factor
7.	Immunoglobulin M (IgM)
8.	HLA-DQ Antigens (HLA-DQ)
9.	Autoantibodies
10.	Immunoglobulin A (IgA)

Related Therapies and Procedures

1.	Gluten-Free Diet