Abstract | AIM: METHODS: RESULTS: We found that 29 of 962 patients (3%) with liver diseases and 5 of 523 patients (0.8%) who underwent OLTx were seropositive for IgA and IgG anti-tTG antibodies. However, celiac disease was biopsy-diagnosed in 16 patients: 4 with autoimmune hepatitis type I, 3 with Wilson's disease, 3 with celiac hepatitis, 2 with primary sclerosing cholangitis, 1 with primary biliary cirrhosis, 1 with Budd-Chiari syndrome, 1 with toxic hepatitis, and 1 with non- alcoholic steatohepatitis. Unexpectedly, the highest prevalence of celiac disease was found in patients with Wilson's disease (9.7%), with which it is only rarely associated. On the other hand, no OLTx patients were diagnosed with celiac disease in our study. A pilot study of the expression of tTG in liver tissue using immunohistochemistry documented the overexpression of this molecule in endothelial cells and periportal hepatocytes of patients simultaneously suffering from celiac disease and toxic hepatitis, primary sclerosing cholangitis or autoimmune hepatitis type I. CONCLUSION:
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Authors | Pavel Drastich, Eva Honsová, Alena Lodererová, Marcela Jarešová, Aneta Pekáriková, Iva Hoffmanová, Ludmila Tučková, Helena Tlaskalová-Hogenová, Julius Spičák, Daniel Sánchez |
Journal | World journal of gastroenterology
(World J Gastroenterol)
Vol. 18
Issue 43
Pg. 6255-62
(Nov 21 2012)
ISSN: 2219-2840 [Electronic] United States |
PMID | 23180946
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- Immunoglobulin A
- Immunoglobulin G
- Gliadin
- Protein Glutamine gamma Glutamyltransferase 2
- Transglutaminases
- GTP-Binding Proteins
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Topics |
- Adolescent
- Adult
- Aged
- Autoantibodies
(blood)
- Biopsy
- Celiac Disease
(blood, diagnosis, epidemiology, immunology)
- Czech Republic
(epidemiology)
- Female
- GTP-Binding Proteins
- Gliadin
(immunology)
- Humans
- Immunoglobulin A
(blood)
- Immunoglobulin G
(blood)
- Immunohistochemistry
- Liver
(enzymology)
- Liver Diseases
(diagnosis, epidemiology, surgery)
- Liver Transplantation
- Male
- Mass Screening
(methods)
- Middle Aged
- Predictive Value of Tests
- Prevalence
- Protein Glutamine gamma Glutamyltransferase 2
- Transglutaminases
(immunology)
- Young Adult
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