Occupational Asthma

01/01/2013 - "Inhalation challenges with allergens are considered the gold standard for the diagnosis of occupational asthma. "
07/03/2015 - "This document reviews briefly relevant human studies of occupational asthma, and experimental models that have been developed (or are being developed) for the identification and characterisation of chemical respiratory allergens. "
02/01/2012 - "The study shows that the cessation of the exposure to allergen in the work place appears the most effective measure in limiting pulmonary function decline in asthmatic workers and underlines the importance of allergic risk assessment and control in the management of occupational asthma."
10/01/2011 - "This study aimed to explore the underlying role of FA exposure in occupational asthma, especially when it is combined with allergen exposure. "
10/01/2006 - "The aim of the study was to ascertain whether in patients with occupational asthma findings persist after withdrawal from occupational allergen exposure. "

10/01/1988 - "Patterns of improvement in spirometry, bronchial hyperresponsiveness, and specific IgE antibody levels after cessation of exposure in occupational asthma caused by snow-crab processing."
03/01/1996 - "In our study, NSBR was confirmed as a common feature of occupational asthma, either IgE mediated (wheat flour) or non-IgE mediated (TDI). "
10/01/1994 - "[A study of occupational asthma and specific IgE in sericulture workers]."
11/01/1983 - "This study demonstrates that inhaled particulates from Tm exoskeletons are potent sensitizers and elicit IgE-mediated occupational asthma. "
11/28/2023 - "Diagnosis involved skin-prick tests, sIgE (ImmunoCAP-specific IgE) measurements, and bronchial challenge tests, confirming occupational asthma from fish bioaerosol exposure. "

03/01/1990 - "Six of these workers underwent methacholine-challenge testing, and three were found to have a significant improvement in responsiveness to methacholine away from work, suggestive of occupational asthma. "
04/01/2011 - "Answers to a self-administered questionnaire led to possible referral for further assessment that included methacholine testing and specific inhalation challenges as the gold standard for confirming occupational asthma. "
01/01/2012 - "Fourteen males with adult-onset, occupational asthma, 26-77 years of age, underwent methacholine inhalation challenges. "
10/01/2008 - "Usefulness of induced sputum in investigating occupational asthma with normal responsiveness to methacholine: a case report."
06/15/2004 - "Recent data suggest that responsiveness to methacholine continues to improve 2 and more years after cessation of exposure to agents causing occupational asthma (OA). "

01/01/2015 - "Specific inhalation challenge (SIC) may be considered the 'gold standard' for the diagnosis of occupational asthma due to persulfate salts. "
12/01/2008 - "Based on comparison with previous published studies, the prevalence of occupational asthma to salt water fish is lower than due to shellfish. "
03/01/2008 - "The aim of this study was to describe the course of bronchial hyperresponsiveness and immunologic test results in patients with occupational asthma due to persulfate salts. "
01/01/2015 - "We recommend to include patch-testing in the diagnosis of suspected occupational asthma due to persulfate salts. "
01/01/2015 - "Between 2003 and 2014, eight patients with suspected occupational asthma due to persulfate salts were examined (7 females, all hair-dressers). "

01/01/1994 - "With the results of the specific challenge test as the gold standard, serial measurement of histamine responsiveness may not appear to be a sensitive diagnostic test for occupational asthma. "
07/17/1996 - "Characterization of histamine releasing factors in diisocyanate-induced occupational asthma."
10/01/1993 - "Lack of role for mononuclear cell-derived histamine releasing factors in occupational asthma due to western red cedar."
05/01/1991 - "Bronchial hyper-responsiveness to isopropyly alcohol and histamine was observed and was likely to be the result rather than a predisposing factor for the development of occupational asthma. "
09/01/1986 - "The diagnosis of occupational asthma was confirmed by significant and sustained changes in serial peak expiratory flow rates at work as compared with a period off work in every individual and significant changes in bronchial responsiveness to histamine at work as compared with a period off work in eight individuals or significant changes in FEV1 at work in the three other subjects. "

11/01/2006 - "Cytokine profiling of local lymph node responses has been proposed as a simple test to identify chemicals, such as low molecular weight diisocyanates, that pose a significant risk of occupational asthma. "
01/01/2013 - "The aim of this study was to establish the sputum inflammatory profile and changes in levels of leukotriene B₄ (LTB₄) and a panel of Th1/Th2 cytokines in subjects with suspected occupational asthma (OA) following specific inhalation challenge (SIC) to high-molecular-weight (HMW) and low-molecular-weight (LMW) agents. "
10/01/2001 - "In order to investigate the cytokine profile in toluene diisocyanate (TDI)-induced occupational asthma, we conducted a quantification of cytokine production in a murine model of respiratory hyperreactivity to TDI. "
07/01/2011 - "Toluene diisocyante-induced occupational asthma (TDI-OA) is an inflammatory disease of airway, composing inflammatory cells and cytokines associated with airway remodeling. "
01/01/2014 - "We established a Wistar rat model of asthma caused by toluene diisocyanate (TDI) exposure, and investigated the relationship between TDI exposure concentrations and respiratory hypersensitivity, airway inflammation, and cytokine secretions in animals, to better understand the mechanism of TDI induced occupational asthma. "

11/01/2008 - "Median CLI costs were significantly higher in men than women (69.9 versus 13.1), workers aged 40 years or older versus those younger than 40 years (90.1 versus 27.4), workers with occupational asthma due to workplace exposure to low versus high molecular weight agents (51.2 versus 38.6), and workers taking inhaled steroids at diagnosis (92 versus 52) and reassessment (81 versus 35). "
03/01/1996 - "Influence of inhaled steroids on recovery from occupational asthma after cessation of exposure: an 18-month double-blind crossover study."
01/01/2003 - "Treatment of occupational asthma includes inhalation steroids, beta 2-agonists, cholinergic antagonists, methylxanthines. "
11/01/1989 - "[Effects of long-term use of inhaled steroids (beclomethasone dipropionate) in patients with occupational asthma no longer exposed]."
04/26/2021 - "A dyspneic 38-year-old male janitor with steroid-dependent occupational asthma refractory to omalizumab therapy was colonized with Candida and Alternaria following a promotion to a managerial position in a moldy office. "

03/01/1996 - "We conclude that inhaled corticosteroids induce a small but significant overall improvement of the asthmatic condition in subjects with occupational asthma caused by high- and low-molecular-weight agents after withdrawal from exposure. "
10/01/2009 - "Clinically useful applications of induced sputum analysis are the detection of non-adherence to corticosteroid therapy, assessment of adequacy of inhaled corticosteroid therapy, long-term therapy management in asthma, oral corticosteroid dose adjustment in refractory asthma and assessment of occupational asthma."
11/21/2007 - "The present review will briefly discuss corticoid-resistant asthma, occupational asthma, aspirin-induced asthma, and the association of asthma with obesity."
09/01/1993 - "We assessed the effect of a nebulized corticosteroid, budesonide, on airway hyperresponsiveness and inflammatory response provoked by inhalation of trimellitic anhydride (TMA) dust, a known cause of occupational asthma in human beings, in guinea pigs sensitized to the free hapten. "
02/01/1999 - "Support for this hypothesis includes: (1) activated T cells and their products can be identified in biopsies from the major variants of the disease (atopic, non-atopic and occupational asthma); (2) colocalization of mRNA for type 2 cytokines to CD4+ and CD8+ cells in atopic and non-atopic asthma; (3) the presence of activated cytokine-producing T cells in corticosteroid-resistant asthma; (4) the association of disease severity with type 2 cytokines, especially IL-5; and (5) the efficacy of cyclosporin A and a monoclonal anti-CD4 in chronic steroid-dependent disease. "

02/01/1999 - "Support for this hypothesis includes: (1) activated T cells and their products can be identified in biopsies from the major variants of the disease (atopic, non-atopic and occupational asthma); (2) colocalization of mRNA for type 2 cytokines to CD4+ and CD8+ cells in atopic and non-atopic asthma; (3) the presence of activated cytokine-producing T cells in corticosteroid-resistant asthma; (4) the association of disease severity with type 2 cytokines, especially IL-5; and (5) the efficacy of cyclosporin A and a monoclonal anti-CD4 in chronic steroid-dependent disease. "
01/01/1997 - "Support for this hypothesis includes: the observations that activated T cells and their products can be identified in biopsies from the major variants of the disease (atopic, nonatopic [intrinsic] and occupational asthma); the co-localization of mRNA for type 2 cytokines to CD4+ and CD8+ cells in atopic and non-atopic asthma; the presence of chronically activated cytokine-producing T cells in corticosteroid-resistant asthma; the association of disease severity with type 2 cytokines, especially IL-5; and the efficacy of cyclosporin A in chronic steroid-dependent disease. "
02/01/2001 - "Vanadium pentoxide (V2O5), a fibrogenic metal associated with occupational asthma, caused a several-fold increase in HB-EGF mRNA expression and protein, whereas the inert metal titanium dioxide had no effect on HB-EGF expression. "

02/01/1999 - "Support for this hypothesis includes: (1) activated T cells and their products can be identified in biopsies from the major variants of the disease (atopic, non-atopic and occupational asthma); (2) colocalization of mRNA for type 2 cytokines to CD4+ and CD8+ cells in atopic and non-atopic asthma; (3) the presence of activated cytokine-producing T cells in corticosteroid-resistant asthma; (4) the association of disease severity with type 2 cytokines, especially IL-5; and (5) the efficacy of cyclosporin A and a monoclonal anti-CD4 in chronic steroid-dependent disease. "
01/01/1997 - "Support for this hypothesis includes: the observations that activated T cells and their products can be identified in biopsies from the major variants of the disease (atopic, nonatopic [intrinsic] and occupational asthma); the co-localization of mRNA for type 2 cytokines to CD4+ and CD8+ cells in atopic and non-atopic asthma; the presence of chronically activated cytokine-producing T cells in corticosteroid-resistant asthma; the association of disease severity with type 2 cytokines, especially IL-5; and the efficacy of cyclosporin A in chronic steroid-dependent disease. "

12/01/1998 - "The results of this study suggest that especially dairy farmers with occupational asthma benefit from the use of a powered dust respirator helmet."
12/01/1998 - "This study investigated the value of powered dust respirator helmets in the treatment of farmers with occupational asthma. "
11/01/2016 - "There is limited evidence for the effectiveness of respirators in preventing occupational asthma. "
06/01/2012 - "The evidence for the effectiveness of respirators in preventing occupational asthma is limited, and other options higher in the list of controls for occupational exposures, notably eliminating or minimising exposures at the source or in the environment, should be used preferentially. "
01/01/2000 - "The effect of the work environment was examined in two patients with occupational asthma with and without the use of a commercially available mask or a dust respirator. "

01/01/2023 - "When protective strategies fail, knowledge of underlying disease mechanisms is necessary to inform targeted therapy development to lessen occupational asthma disease severity and occurrence."
12/01/2012 - "Occupational asthma is a disease that is potentially preventable and often curable; positive outcomes are dependent more on changes in the workplace than on pharmacological therapy."
05/01/1990 - "This article defines occupational asthma as well as reviews the current tests used in diagnosing occupational asthma and therapies for treatment of patients."
05/01/1990 - "A clinician's approach to determine the diagnosis, prognosis, and therapy of occupational asthma."
10/01/1988 - "[Is protective therapy possible in occupational asthma? "

04/01/2006 - "There are very few studies on immunotherapy in occupational asthma. "
04/01/2006 - "To review clinical data on immunotherapy applied to occupational asthma. "
04/01/2006 - "Immunotherapy: an option in the management of occupational asthma?"
09/01/1997 - "Usefulness of specific bronchial challenge in monitoring immunotherapy in occupational asthma."
10/01/2023 - "We highlight current research on the association between occupational rhinitis and occupational asthma and the role of immunotherapy in this disease. "

04/01/2011 - "Short-term exposure studies showed that respiratory protective devices can reduce bronchial responses to sensitizing agents in patients with occupational asthma, but do not provide complete protection. "
04/01/2002 - "Effect of respiratory protective devices on development of antibody and occupational asthma to an acid anhydride."

12/01/1991 - "The purpose of this study was to identify the strengths and limitations of using portable peak flowmeters to document suspected cases of occupational asthma that were reported to a statewide surveillance project. "
12/01/1991 - "The use of portable peak flowmeters in the surveillance of occupational asthma."