Cytokines

Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.

Also Known As:

Networked: 164289 relevant articles (5649 outcomes, 18174 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wang, Wei: 220 articles (06/2022 - 03/2002)
2.	Wang, Jing: 188 articles (08/2022 - 01/2003)
3.	Zhang, Wei: 180 articles (12/2022 - 11/2002)
4.	Li, Wei: 167 articles (11/2022 - 04/2002)
5.	Netea, Mihai G: 167 articles (08/2022 - 01/2002)
6.	Li, Yan: 158 articles (10/2022 - 02/2003)
7.	Wang, Yan: 155 articles (09/2022 - 04/2006)
8.	Liu, Yang: 151 articles (12/2022 - 04/2004)
9.	Li, Li: 150 articles (08/2022 - 09/2003)
10.	Zhang, Yan: 148 articles (08/2022 - 03/2002)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2023 - "In vitro and in vivo studies demonstrate that M2H@RPK dramatically decreases proinflammatory cytokines, controls synovial inflammation, and provides significant therapeutic efficacy by reducing joint damage. " 01/01/2023 - "Extensive research is in progress now via multinational consortia relating to the specific type(s) of inflammation involved, whether age and prior febrile illness affect this, and whether measuring and following serum and/or CSF cytokines can help determine the best treatment." 02/01/2021 - "Although no specific patterns of cytokine level alteration could be identified, significantly attenuated plasma levels of inflammation markers were observed in one particular patient who happened to have normalized spleen size and most remarkable reduction in JAK2 mutant allele burden, indicating all-around improvement in every aspect of this case. " 01/01/2020 - "CONCLUSION & INFERENCES: Bipolar stimulation for 1 hour daily using intermittent 5 Hz parameters is most effective in improving colonic inflammation in TNBS-treated rats by inhibiting pro-inflammatory cytokines and increasing anti-inflammatory cytokines via the modulation of the autonomic function." 01/01/2017 - "Our results suggest that primary human small airway lung epithelial cells (SAECS) exposed to HTS in the presence and absence of a strong pro-inflammatory stimulus exhibit very distinct effects on cellular response, where HTS is highly effective in attenuating cytokine-induced pro-inflammatory responses via mechanisms that involve transcriptional regulation of inflammation which is cell type and stimulus specific. "
2.	Neoplasms (Cancer) 01/01/2014 - "Such TRUCKs, T cells redirected for universal cytokine-mediated killing, exhibited remarkable efficacy against solid tumors with diverse cancer cell phenotypes, suggesting their evaluation in clinical trials. " 01/01/2023 - "The secretory cytokines in the tumor microenvironment primarily responsible for developing blood vessels in the tumor are dramatically reduced by treatment. " 01/01/2020 - "As a proof-of-principle we demonstrate highly efficient knockout of ADAM17 and PDCD1, genes that have a functional impact on NK cells, and demonstrate that these gene-edited NK cells have significantly improved activity, cytokine production, and cancer cell cytotoxicity. " 01/01/2019 - "Furthermore, we here discuss timely attempts of how to: i) control 'on-tumor off-target' effects; ii) introduce Signal 3 (cytokine responsiveness of CAR cells) as an important building-block into the CAR concept; iii) most efficiently eliminate CAR cells once full remission has been obtained. " 01/01/2018 - "UCAR T cells mediated robust immune synapses with tumor targets forming more polarized microtubule organizing centers and exhibited improved cytotoxicity and cytokine release over best monospecific and bispecific CAR T cells per patient tumor profile. "
3.	Infections 01/01/2018 - "The effects of diminished CD200-CD200R signaling by LdCen-/- were most evident in the suppression of IL-10-producing CD4+ T cells that helped enhance more Th1 cytokine producing and multi-functional T cells compared to wild-type infection. " 04/01/2015 - "These results demonstrated that an increase in cytokine-producing lymphocytes and the development of MGCs that engulfed fungal cells were associated with the protection against pulmonary infection with highly virulent C. " 03/01/2008 - "We conclude that the alkaloidal fraction was the most effective in reducing monocyte infection rates and cytokine levels. " 10/01/1998 - "The compositions and magnitudes of innate cytokine responses are modulated, by the nature of the infectious agent, to facilitate accessing of the anti-microbial defense functions most beneficial in defense against the particular infection. " 06/29/2023 - "These findings suggest the important roles of these cytokines in protection against LSDV infections. "
4.	Colitis 09/06/2021 - "SJMHE1 treatment significantly suppressed DSS-induced acute and chronic colitis, improved disease activity and pathological damage to the colon and modulated the expression of pro-inflammatory and anti-inflammatory cytokines in splenocytes and the colon. " 05/01/2020 - "SH significantly ameliorates the symptoms of DSS-induced colitis mice and the potential mechanism of SH may involve in multiple kinds of metabolic pathway including the regulation of gut microbiota, inflammatory mediators and cytokines." 12/13/2019 - "obv egg significantly ameliorated the severity of the DSS colitis, indicated by the reduced disease manifestations, improved histopathological scores correlated with the up regulation of Treg responses and down regulation of proinflammatory cytokines. " 02/01/2018 - "As compared to ASA, ASA-Tris conjugation provides significant protection against the colonic injury and cytokine-mediated progression of inflammatory events in experimental colitis without influencing the gastric epithelial structure." 04/18/2011 - "In both models of disease the absence of HVEM resulted in a significant reduction in colitis and inflammatory cytokine production. "
5.	Sepsis (Septicemia) 11/09/2020 - "Our data suggest that MAIT cells are highly activated and become dysfunctional during clinical sepsis, and contribute to tissue-specific cytokine responses that are protective against mortality during experimental sepsis." 08/19/2020 - "The results indicated that LL-37 exhibits multiple protective actions on septic mice; firstly, the survival of CLP mice was found to be improved by LL-37 by the suppression of the macrophage pyroptosis that induces the release of pro-inflammatory cytokines (such as IL-1β) and augments inflammatory reactions in sepsis; secondly, the release of neutrophil extracellular traps (NETs), which have potent bactericidal activity, is enhanced by LL-37, and protects mice from CLP-induced sepsis; thirdly, LL-37 stimulates neutrophils to release antimicrobial microvesicles (ectosomes), which improve the pathological condition of sepsis. " 12/01/2017 - "These data suggest that Ecballium elaterium contains some components that exert protective effects against SAE in part by attenuating accumulation of proinflammatory cytokines, which may be important contributors to its anti-inflammatory effects during sepsis." 02/01/1993 - "Recombinantly derived forms of these natural cytokine antagonists have proven effective in preventing many of the adverse consequences of sepsis. " 01/01/2022 - "Further studies demonstrated that inhibition of EGR1 significantly decreased ADAM17 expression and the pro-inflammatory cytokine secretion in vitro, and improved the survival and inflammatory response of sepsis mouse model. "

Related Drugs and Biologics

1.	Interleukin-6 (Interleukin 6)
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.	Cytokines
4.	Chemokines
5.	Interleukin-10 (Interleukin 10)
6.	Proteins (Proteins, Gene)
7.	Interleukins
8.	Interleukin-2 (IL2)
9.	Interleukin-12 (IL 12)
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Drug Therapy (Chemotherapy)
4.	Oral Administration
5.	Transplantation