Abstract | BACKGROUND:
Toluene diisocyante-induced occupational asthma (TDI-OA) is an inflammatory disease of airway, composing inflammatory cells and cytokines associated with airway remodeling. Majority of the patients with TDI-OA presented persistent asthma. Therefore, early diagnosis is essential for the favorable prognosis. We investigated to identify serologic markers for early diagnosis of TDI-OA. METHODS: RESULTS: There were significant differences in the serum levels of MMP-9 and VEGF between two groups (p < 0.05). Using the optimal cutoff value of MMP-9 (182.96 ng/mL), the sensitivity and specificity were 79.7% and 80.0%, respectively, with the area under the curve (AUC) of 0.815. When the cytokines were combined to improve sensitivity, the combined values of MMP-9, VEGF, and IL-8 comprised the best set, for which the AUC increased to 0.822 and the sensitivity increased to 82.6% but specificity decreased to 75.8%. CONCLUSIONS: The single serum cytokine MMP-9 level or the combined cytokines MMP-9, VEGF, and IL-8 can be used as meaningful serologic markers for identifying patients with TDI-OA among exposed workers.
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Authors | Joo-Hee Kim, Jeong-Eun Kim, Gil-Soon Choi, Hyun-Young Kim, Young-Min Ye, Hae-Sim Park |
Journal | Respiratory medicine
(Respir Med)
Vol. 105
Issue 7
Pg. 1091-4
(Jul 2011)
ISSN: 1532-3064 [Electronic] England |
PMID | 21439806
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier Ltd. All rights reserved. |
Chemical References |
- Biomarkers
- Tissue Inhibitor of Metalloproteinase-1
- Transforming Growth Factor beta1
- Vascular Endothelial Growth Factor A
- Toluene 2,4-Diisocyanate
- Matrix Metalloproteinase 9
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Topics |
- Adult
- Asthma
(blood, chemically induced, diagnosis)
- Biomarkers
(blood)
- Chemical Industry
- Early Diagnosis
- Female
- Humans
- Male
- Matrix Metalloproteinase 9
(blood)
- Occupational Diseases
(blood, chemically induced, diagnosis)
- Occupational Exposure
(adverse effects)
- Tissue Inhibitor of Metalloproteinase-1
(blood)
- Toluene 2,4-Diisocyanate
(toxicity)
- Transforming Growth Factor beta1
(blood)
- Vascular Endothelial Growth Factor A
(blood)
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