Cough-Variant Asthma

Asthma which is characterized by CHRONIC COUGH that is nonproductive without other asthmatic symptoms, e.g., WHEEZING, and PAROXYSMAL DYSPNEA. Cough-variant asthma is accompanied by AIRWAY HYPERSENSITIVITY and may progress to classical asthma without treatment.

Also Known As:

Networked: 205 relevant articles (23 outcomes, 51 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Asthma (Bronchial Asthma)
2.	Chronic Cough
3.	Cough
4.	Inflammation (Inflammations)
5.	Pneumonia (Pneumonitis)

Experts

1.	Fujimura, Masaki: 11 articles (10/2020 - 06/2003)
2.	Niimi, Akio: 6 articles (05/2021 - 03/2006)
3.	Qin, Weiwei: 5 articles (01/2022 - 01/2019)
4.	Tan, Ninghua: 5 articles (01/2022 - 01/2019)
5.	Wang, Zhen: 5 articles (01/2022 - 01/2019)
6.	Nakajima, Takeo: 4 articles (03/2022 - 06/2006)
7.	Nishimura, Yoshihiro: 4 articles (03/2022 - 06/2006)
8.	Tong, Xiyang: 4 articles (01/2022 - 01/2019)
9.	Jia, Yuning: 4 articles (05/2021 - 01/2019)
10.	Wu, Xingdong: 4 articles (05/2021 - 01/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cough-Variant Asthma:

1.	montelukast (Singulair)FDA Link 12/23/2021 - "This systematic review will provide evidence to determine whether acupuncture combined with montelukast sodium is an effective and safe intervention for patients with cough variant asthma in children. " 04/01/2008 - "The efficacy of montelukast and airway mast cell profiles in patients with cough variant asthma." 12/23/2021 - "This study provides a high-quality synthesis to assess the effectiveness and safety of acupuncture combined with montelukast sodium on cough variant asthma in children. " 12/23/2021 - "Clinical randomized controlled trials related to acupuncture combined with montelukast sodium on cough variant asthma in children were included in this study. " 12/23/2021 - "Therefore, combined with existing reports, a systematic review and meta-analysis of acupuncture combined with montelukast sodium in the treatment of cough variant asthma in children were carried out to obtain conclusive results. "
2.	Adrenal Cortex Hormones (Corticosteroids)IBA 12/04/2018 - "However, little is known about the treatment of cough-variant asthma except for inhaled corticosteroid (ICS). " 12/01/2010 - "Inflammatory subtypes in cough-variant asthma: association with maintenance doses of inhaled corticosteroids." 05/01/2003 - "In patients with cough variant asthma, the slope in patients not taking inhaled corticosteroids (ICS) was 0.032 +/- 0.007 L/year, which was not significantly different from that in patients taking ICS (- 0.027 +/- 0.010 L/year). " 12/01/1994 - "To evaluate the course of ten patients with cough variant asthma and their response to inhaled corticosteroids. " 06/01/2005 - "The aims of the present study were to examine the prevalence and clinical features of cough variant asthma (CVA) among patients with chronic and persistent cough at an outpatient clinic in Japan, and the efficacy of treatment with an inhaled corticosteroid. "
3.	Capsules (Microcapsules)IBA 12/01/2019 - "This analysis will provide updated evidence for whether Suhuang anti-tussive capsule is an effective and safe intervention for cough variant asthma. " 12/01/2019 - "This study will provide high-quality synthesis based on current evidence of Suhuang anti-tussive capsule treatment for cough variant asthma. " 12/01/2019 - "Four English databases (PubMed, Web of science, EMBASE, and Springer Cochrane Library) and 4 Chinese databases (Wanfang Database, Chinese Scientific Journal Database, China National Knowledge Infrastructure Database, and Chinese Biomedical Literature Database) were researched for the randomized controlled trials of Suhuang anti-tussive capsule for cough variant asthma. " 01/30/2022 - "Our previous studies have demonstrated that SH capsule possesses significant ameliorative effects on cough variant asthma (CVA), sputum obstruction and airway remodeling. " 12/01/2019 - "A traditional Chinese patent medicine-Suhuang zhike capsule for cough variant asthma in adults: A protocol of systematic review and meta-analysis of randomized controlled trials."
4.	Antitussive Agents (Antitussives)FDA Link 09/01/2019 - "This study aimed to detect an effective therapeutic approach for cough variant asthma (CVA) through evaluating the relaxant effect of these two bioactive herbal monomers as antitussive and antiasthmatic on rat tracheal smooth muscle. " 02/10/2016 - "Suhuang antitussive capsule (Suhuang), a traditional Chinese medication, is found effective in treating chronic cough and cough variant asthma (CVA). " 01/01/2019 - "Suhuang antitussive capsule (SH Capsule), a classic traditional Chinese medicine prescription, has been used for the treatment of post-cold cough and cough variant asthma in the long clinical application. " 10/10/2022 - "Whether cysteinyl-leukotriene receptor antagonists (LTRAs) have a similar antitussive effect to inhaled corticosteroids and long-acting β2-agonist (ICS/LABA), and that LTRA plus ICS/LABA is superior to LTRAs alone or ICS/LABA alone in treating cough variant asthma (CVA) remain unclear. " 05/10/2023 - "β-Hydroxybutyric acid upregulated by Suhuang antitussive capsule ameliorates cough variant asthma through GSK3β/AMPK-Nrf2 signal axis."
5.	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/19/2023 - "To study the value of alveolar nitric oxide concentration (CaNO) in the identification and disease control of cough variant asthma. " 05/23/2019 - "This study aimed to investigate the diagnostic value of fractional exhaled nitric oxide (FeNO) combined with small airway functional parameters in cough variant asthma. " 09/09/2023 - "To investigate the role of combined impulse oscillometry (IOS) and fractional exhaled nitric oxide (FeNO) in the diagnosis of cough variant asthma (CVA) in preschool children. " 01/01/2023 - "A comparative study on the value of lower airway exhaled nitric oxide combined with small airway parameters for diagnosing cough-variant asthma." 01/01/2020 - "Objective: We aimed to evaluate the diagnostic value of fractional exhaled nitric oxide (FeNO) in cough-variant asthma (CVA) detection. "
6.	Bronchodilator Agents (Bronchodilators)IBA 01/01/2020 - "Determinants of response to bronchodilator in patients with cough variant asthma- A randomized, single-blinded, placebo-controlled study." 01/01/2022 - "Many patients with cough variant asthma (CVA) are underdiagnosed and undertreated due to the atypical symptoms, low diagnostic sensitivity of bronchodilator response (BDR), and limited application of bronchial challenge test. " 01/01/2020 - "Not all patients with cough variant asthma (CVA) show responsiveness to bronchodilators (RB) in clinic. " 11/01/2006 - "Longitudinal changes of pulmonary function and bronchial responsiveness in cough-variant asthma treated with bronchodilators alone." 01/01/2002 - "The diagnosis of cough variant asthma should only be made in older children after variable airflow obstruction and response to bronchodilator has been demonstrated physiologically. "
7.	Budesonide (Pulmicort)FDA LinkGeneric 11/01/2013 - "Efficacy of procaterol combined with inhaled budesonide for treatment of cough-variant asthma." 11/01/2016 - "The databases CNKI, Wanfang Data, VIP, PubMed, EMbase, and BioMed Central were searched for randomized controlled trials (RCTs) of montelukast sodium combined with budesonide in the treatment of children with cough variant asthma. " 09/01/2023 - "Key Words: Montelukast, Budesonide, Cough variant asthma, Children, Pulmonary function, Inflammatory markers, Meta-analysis." 09/01/2023 - "Effect of Montelukast Combined with Budesonide on Inflammatory Response and Pulmonary Function in Children with Cough Variant Asthma: A Meta-analysis." 06/25/2021 - "Evaluation of efficiency and safety of combined montelukast sodium and budesonide in children with cough variant asthma: A protocol for systematic review and meta-analysis."
8.	Leukotriene Antagonists (Leukotriene Receptor Antagonists)IBA 04/01/2009 - "To study the curative effect of leukotriene receptor antagonist on cough variant asthma (CVA). " 04/01/2009 - "[Effect of leukotriene receptor antagonist on cough variant asthma]." 12/04/2018 - "The aim of this study was to validate the additive efficacy of a leukotriene receptor antagonist (LTRA) on cough score and respiratory function in patients with cough-variant asthma being treated with ICS. " 09/01/2004 - "The leukotriene receptor antagonist montelukast seems to be effective in the treatment of cough variant asthma. " 09/01/2010 - "Comparable effect of a leukotriene receptor antagonist and long-acting beta₂-adrenergic agonist in cough variant asthma."
9.	AcidsIBA 01/01/2020 - "Different treatable traits exist with cough variant asthma (CVA)/eosinophilic bronchitis responding to anti-inflammatory treatment and non-acid reflux being treated with promotility agents rather the anti-acid drugs. " 11/01/1996 - "Sensitization of the cough reflex is a unifying hypothesis for chronic dry cough in several conditions, including gastroesophageal acid reflux, angiotensin-converting enzyme inhibitor cough, and cough-variant asthma. " 05/10/2023 - "β-Hydroxybutyric acid upregulated by Suhuang antitussive capsule ameliorates cough variant asthma through GSK3β/AMPK-Nrf2 signal axis." 01/01/2022 - "The study on the clinical efficacy and low hospitalization cost of the self-prepared lung and asthma-restorative soup in patients with cough variant asthma significantly improved the patients' arterial oxygen saturation, acid-base value, arterial partial pressure of oxygen, and partial pressure of carbon dioxide and effectively controlled the heart rate and respiratory rate with high safety, which is worth further promotion."
10.	Methacholine Chloride (Methacholine)FDA Link 01/01/1997 - "The patient was given a diagnosis of cough-variant asthma because her sputum contained many eosinophils and her airway responsiveness to methacholine was slightly higher than normal. " 03/09/2009 - "Features of cough variant asthma and classic asthma during methacholine-induced brochoconstriction: a cross-sectional study." 01/01/2007 - "Another look at airway resistance showed a less rapid rate of rise in resistance in cough-variant asthma with increasing methacholine dosing than in classic asthma. " 12/01/2005 - "Maximal airway response to methacholine in cough-variant asthma: comparison with classic asthma and its relationship to peak expiratory flow variability." 12/01/2002 - "The importance of maximal airway response to methacholine in the prediction of wheezing development in patients with cough-variant asthma."

Therapies and Procedures

1.	Therapeutics 01/01/2016 - "This study aimed to evaluate the efficacy and safety of Chinese herbal medicine auxiliary therapy (CHMAT) in treating childhood cough variant asthma (CVA). " 01/01/2016 - "Clinical Efficacy and Safety of Chinese Herbal Medicine Auxiliary Therapy for Childhood Cough Variant Asthma: A Systematic Review and Meta-analysis of 20 Randomized Controlled Trials." 01/01/2023 - "Latent myofascial trigger points injection therapy for adult cough variant asthma: A randomized controlled trial." 12/01/2007 - "This review focuses on current therapies used for cough variant asthma, also highlighting potential therapeutic targets for this condition." 01/01/2022 - "The comprehensive computer retrieval related to comparison between acupoint application and nonacupoint application therapy for cough variant asthma was carried out in various databases (n = 8) from database establishment until July 4, 2021. "
2.	Chinese Traditional Medicine (Traditional Chinese Medicine) 12/05/2021 - "In the present study, guided by the traditional Chinese medicine theory of the exterior-interior relationship between the lungs and the large intestine, the pathogenesis of cough variant asthma (CVA) and the treatment mechanism of EJL on CVA were explored. " 01/01/2022 - "Acupoint application therapy of traditional Chinese medicine is an effective procedure to treat cough variant asthma. " 01/01/2022 - "Assessment of Acupoint Therapy of Traditional Chinese Medicine on Cough Variant Asthma: A Meta-analysis." 01/30/2021 - "Huanglong cough oral liquid (HL), an important traditional Chinese medicine prescription for treating pediatric cough variant asthma (CVA) in Nanjing hospital of traditional Chinese medicine for many years. " 01/01/2013 - "Traditional Chinese medicine (TCM) has shown significant efficacy in the treatment of cough variant asthma (CVA), a special type of asthma. "
3.	Acupuncture Points (Acupuncture Point) 08/01/2018 - "To evaluate the efficacy and safety of stimulating acupoints in subjects with childhood cough variant asthma (CVA). " 08/01/2018 - "Effect and safety of stimulating acupoints in children with cough variant asthma: A Meta-analysis." 01/01/2022 - "The comprehensive computer retrieval related to comparison between acupoint application and nonacupoint application therapy for cough variant asthma was carried out in various databases (n = 8) from database establishment until July 4, 2021. " 01/01/2022 - "The current study is designed to systematically assess the effectiveness of acupoint application therapy in traditional medicine for patients with cough variant asthma. " 01/01/2022 - "Acupoint application therapy of traditional Chinese medicine is an effective procedure to treat cough variant asthma. "
4.	Acupuncture Therapy 01/01/2021 - "The comprehensive computer retrieval Chinese journal full-text database (CNKI), Chinese science and technology periodical database (VIP), ten thousand data knowledge service platform (WanFang Data), PubMed, Embase, and the Cochrane Library were used to collect literature for relevant randomized controlled trials (RCT) of acupuncture treatment of cough-variant asthma, as well as to retrieve papers and add reference retrieval after literature review, in accordance with the standard of literature filtering, data extraction, and quality evaluation. " 01/01/2021 - "The clinical curative effect of acupuncture treatment for cough-variant asthma is precise and has certain advantages in relieving symptoms and reducing the recurrence rate. " 01/01/2021 - "In recent years, there have been many clinical reports on acupuncture treatment of cough-variant asthma, but no researcher has objectively analysed and evaluated the efficacy and safety of acupuncture treatment of cough-variant asthma from the perspective of evidence-based medicine. " 01/01/2021 - "Acupuncture Treatment for Cough-Variant Asthma: A Meta-Analysis."
5.	Traditional Medicine (Folk Remedies) 01/01/2022 - "The current study is designed to systematically assess the effectiveness of acupoint application therapy in traditional medicine for patients with cough variant asthma. "