Abstract | BACKGROUND: OBJECTIVE: METHODS: Fourteen patients with cough variant asthma participated in a randomized, double-blind, placebo-controlled trial with a 7- to 10-day baseline period and a 4-week treatment period with montelukast, 10 mg, or placebo daily. Inclusion criteria were (1) chronic cough with a duration of at least 4 weeks with minimal or no wheezing or dyspnea and (2) forced expiratory volume in 1 second of 50% to 85% of predicted and reversibility of 12% with use of an inhaled beta-agonist or forced expiratory volume in 1 second greater than 85% and positive methacholine challenge results. Patients fulfilled the minimum criteria for cough frequency and symptom scores for randomization. RESULTS: Eight patients received montelukast and 6 received placebo. The primary efficacy variable, mean percentage change from baseline in cough frequency, was significantly improved by the second week, and by the fourth week the mean percentage change from baseline was 75.7% for the treatment group and 20.7% for the placebo group. CONCLUSIONS:
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Authors | Sheldon L Spector, Ricardo A Tan |
Journal | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
(Ann Allergy Asthma Immunol)
Vol. 93
Issue 3
Pg. 232-6
(Sep 2004)
ISSN: 1081-1206 [Print] United States |
PMID | 15478381
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acetates
- Adrenergic beta-Agonists
- Anti-Asthmatic Agents
- Antitussive Agents
- Cyclopropanes
- Leukotriene Antagonists
- Quinolines
- Sulfides
- Methacholine Chloride
- montelukast
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Topics |
- Acetates
(therapeutic use)
- Adrenergic beta-Agonists
(administration & dosage, therapeutic use)
- Adult
- Aged
- Anti-Asthmatic Agents
(administration & dosage, therapeutic use)
- Antitussive Agents
(administration & dosage, therapeutic use)
- Asthma
(complications, drug therapy)
- Bronchial Provocation Tests
- Cough
(drug therapy, etiology)
- Cyclopropanes
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Forced Expiratory Volume
(drug effects)
- Humans
- Leukotriene Antagonists
(administration & dosage, therapeutic use)
- Male
- Methacholine Chloride
- Middle Aged
- Monitoring, Ambulatory
- Pilot Projects
- Quinolines
(therapeutic use)
- Severity of Illness Index
- Sulfides
- Treatment Outcome
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