Efficacy of procaterol combined with inhaled budesonide for treatment of cough-variant asthma.

Abstract

BACKGROUND AND OBJECTIVE:

Procaterol, a selective, short-acting beta-2 adrenoceptor agonist, is effective in treating 'classical' asthma, but its efficacy for cough-variant asthma (CVA) is unknown. We evaluated the efficacy and safety of procaterol combined with budesonide for CVA.

METHODS:

A prospective, randomized, double-blind, placebo-controlled, multicenter trial in China was conducted. One hundred and fifty-nine patients diagnosed with CVA (aged 18-75 years) were randomly divided into two groups to receive twice daily for 8 weeks, inhaled budesonide 100 μg plus either oral procaterol 25 μg or placebo. Primary and secondary efficacy variables were cough symptom severity scores and Leicester Cough Questionnaire (LCQ) life quality scores. Adverse events were also assessed.

RESULTS:

The budesonide/placebo and budesonide/procaterol groups contained 80 and 78 participants (one excluded for later diagnosis of eosinophilic bronchitis), respectively, with similar baseline characteristics. Daily cough score declined during treatment in both groups and was lower in the budesonide/procaterol group at 8 (0.44 vs 0.73) and 10 (0.36 vs 0.69) weeks (P < 0.05). Compared with the budesonide/placebo group, the proportion of patients with a reduction of 3 points or greater (66% vs 42%) and that of patients scoring 0 points (63% vs 51%) was higher in the budesonide/procaterol group for daily cough scores (P < 0.05). At 8 weeks, LCQ score improvement was superior in the budesonide/procaterol group (38.94 ± 19.24 vs 32.71 ± 18.92; P < 0.05).

CONCLUSION:

Procaterol combined with budesonide was well tolerated and effective at improving cough symptoms and quality of life in patients with CVA.

• Authors: Wuping Bao, Qin Chen, Yanping Lin, Huiguo Liu, Guangdong Zhao, Zhibin Chen, Xin Zhou
• Journal: Respirology (Carlton, Vic.) (Respirology) Vol. 18 Suppl 3 Pg. 53-61 (Nov 2013) ISSN: 1440-1843 [Electronic] Australia
• PMID: 24188204 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
• Copyright: © 2013 The Authors. Respirology © 2013 Asian Pacific Society of Respirology.

Chemical References

• Adrenergic beta-2 Receptor Agonists
• Bronchodilator Agents
• Budesonide
• Procaterol

Topics

• Adrenergic beta-2 Receptor Agonists (adverse effects, pharmacology, therapeutic use)
• Adult
• Asthma (drug therapy, epidemiology, physiopathology)
• Bronchodilator Agents (adverse effects, pharmacology, therapeutic use)
• Budesonide (adverse effects, pharmacology, therapeutic use)
• China
• Comorbidity
• Cough (drug therapy, epidemiology, physiopathology)
• Dose-Response Relationship, Drug
• Double-Blind Method
• Drug Therapy, Combination
• Female
• Forced Expiratory Volume (drug effects, physiology)
• Humans
• Male
• Middle Aged
• Procaterol (adverse effects, pharmacology, therapeutic use)
• Prospective Studies
• Treatment Outcome
• Vital Capacity (drug effects, physiology)